Advance in immunopathogenesis for systemic lupus erythematosus / 国际儿科学杂志

Systemic lupus erythematosus is a typical autoimmune disease commonly seen in childhood, the immunnopathogenesis of which is complicated. Along with the rapid advances of immunology and molecular biology, all the associated research has found that the onset of systemic lupus erythematosus is associated with dysfunction of T cells and B cells. They focus on the break of the normal autoimmune immunity and the form of malgenic autoantibody. It is also connected with primary immunodeficiency. The dysfunction of inherent immunity contributes to the break of autoimmune and the progression of the disease.