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OBJECTIVE: To introduce the research progress of dosage regimen of piperacillin/tazobactam and its rational offer reference for clinical use. METHODS: The domestic and oversea pertinent articles were searched, analyzed and summarized, and the difference between prolonged infusion or continuous infusion and traditional infusionin pharmacodynamics and clinical trials were compared. RESULTS: The optimized dosage regimen could achieve higher pharmacodynamics goals, with clinical efficacy and bacterial clearance not inferior to the traditional dosage regimen. CONCLUSION: The prolonged or continuous infusion strategy should be recommended for piperacillin/tazobactam in the clinic.
RESUMEN
Objective To offer reference to reasonable clinical use of piperacillin sodium sodium-tazobactam sodium .Methods We reviewed pharmacokinetic/pharmacodynamic studies , clinical trails and implementation of piperacillin sodium-tazobactam sodi-um alternative dosing regimen in recent .Results The alternative dosing regimens , prolonged and continuous infusion , could maximise the likelihood of achieving desirable pharmacodynamic targets and improve clinical effectiveness .Conclusion It’ s needed to improve the strategies of alternative dosing regimens for clinical practice .