Large Cell Neuroendocrine Carcinoma of Anal Canal: Report of a Case

A neuroendocrine carcinoma of the anal canal is a very rare entity; however, this type of tumor is known for its aggressive progression and poor prognosis. We describe the case of a 58-year-old female with a neuroendocrine carcinoma arising in the anal canal. The tumor was found in the anal canal with multiple liver metastases. The patient died due to massive liver metastases 11months after diagnosis and operation. For its rarity and clinical significance, we report the case with a review of the literature.

Cirurgia de resgate no carcinoma de canal anal / Salvage surgery in anal canal carcinoma

OBJETIVOS: Avaliar a sobrevida dos pacientes portadores de carcinoma epidermóide do canal anal submetidos a cirurgia de resgate, por recidiva ou falha do tratamento radioquimioterápico inicial. MÉTODO: Análise retrospectiva dos pacientes portadores de carcinoma epídermóide do canal anal submetidos a cirurgia de resgate, de outubro de 1986 a setembro de 2000. RESULTADOS: Foram matriculados 93 pacientes portadores de carcinoma epidermóide do canal anal no período, e 21 (22,5 por cento) foram submetidos a resgate cirúrgico. Em 19 pacientes (91 por cento) foi realizada amputação abdominoperineal do reto (operação de Miles), em um paciente exenteração pélvica total e em um paciente excisão local. Não houve mortalidade operatória. A sobrevida média do grupo após resgate cirúrgico foi de 24 meses. CONCLUSÕES: Após recidiva e/ou falha da radioquimioterapia, a cirurgia de resgate é importante no controle locorregional do carcinoma epidermóide do canal anal.

BACKGROUND: Carcinoma of the anal canal is a rare neoplasia, the treatment of wich is based on chemoradiation Surgery is recommended alter treatment failure and recurrence. METHOD: A retrospective review from October 1986 to September 2000 of all patients who underwent salvage surgery alter chemoradiotherapy failure. Patients were reviewed as to time until recurrence and overall survival. RESULTS: Ninety-three patients with epidermoid carcinoma of the anal canal were reviewed. Twenty-one patients (22,5 percent) with residual or recurrent disease underwent salvage surgery. 19 patients (91 percent) underwent abdomino-perineal resection, 1 patient underwent pelvic exenteration and local resection was performed in 1 patient. There was no operative mortality. The overall survival was 24 months. CONCLUSIONS: Salvage surgical resection for anal canal carcinoma can be expected te yieid a number of survivors from residual/recurrent disease.