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Objective To study the effect of extract of cockroach on animals with acute hepatic injury and its antiviral action in vitro. Methods The animal models with hepar injury were established by CCl4, bcg vaccine and lipopolysaccharide (LPS) . And the activities of ALT and AST in serum were measured. Serum of ducks was separated after cockroach extract was administrated. The serum was added to the culture fluid of HBV-DNA transfected hepatic cancer cells-HepG2. Results After the cockroach extract was administrated, the activities of ALT and AST in mouse serum were reduced. Both the therapeutic indexes of cockroach extract and lamivudine were larger than 2. Conclusions Cockroach extract can improve the liver function of animals with acute hepatic injury, and inhibit the secretion of ALT and AST in serum.
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OBJECTIVE To study the antiviral effect of Shenghuangketong ointment(SO)in vivo experiments.METHODS The inhibition effect of SO on the HSV-infected mice with the estimation of its antiviral action.RESULTS SO had an obvious antiviral action and the inhibition effect on the HSV-infected mice.There was significant difference P
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OBJECTIVE:To investigate the antiviral action of emodin in combination with other Chinese active medicine components on Coxsackie virus B3(CVB3) and explore the possible antiviral mechanism.METHODS:Hep-2 cells infected by CVB3 were cultured with different concentration and proportion of the emodin and other Chinese medicine components for 72 hours and their inhibitory effects on CVB3 replication were evaluated with cell survival rates by MTT assay.RESULTS:In the Hep-2 cell system,all the combinations between emodin and other medicine components could inhibit cytopathic effect(CPE) of CVB3-infected cells,increase cells' survival rates and decrease the cytotoxicity.The drug combination which showed the best effect of killing viruses directly was emodin:curcumine:banlangen(2:1:2),and the one showing the highest efficacy in inhibiting the replication of CVB3 in cells was emodin:curcumine:banlangen(2:0:1).CONCLUSION:The toxicity of emodin was reduced and its anti-CVB3 activity was enhanced by its combined use with other Chinese active medicine components.