Analytical Method, Chemistry and Properties of Fructose, Sucrose and Ascorbic Acid in Pear Fruit Juice

Pear is a gently sweet fruit, arich source of several nutrientsincludingfiber, sugar, vitamin C molecules, and potassium. This article reports the history, consumption, Types, health benefits, and diseases of various fruit juices. Carbohydrates, Fructose, sucrose, vitamin C, fibers, vitamins, and minerals are prime constituents present in almost all juices. The nutrition composition, manufacturing technique, processing steps, specification, stability data, contamination, and related details of pear juice are discussed in this review. The pharmacological and functional applications of pear juice like Anti-diabetic, Anti-hyperlipidemic, Anti-inflammatory, and Cardio-protective, etc. are covered with their mechanism of action. The marketed preparation and patents are also highlighted. Moreover, the analytical estimation of active constituents by spectroscopy and chromatography [like UV, HPLC, UPLC, and mass spectroscopy] isexplained in this article. The physic-chemical properties, synthesis, chemistry, biological study, pharmacokinetics, and pharmacodynamics of fructose, sucrose, and ascorbic acid, which are chief phytoconstituents in pear juice, are explained in the present article. This review suggests therapeutic pharmacological andanalytical techniques available for estimating sucrose, fructose, and ascorbic acid analytically and bioanalytically. This will contribute in creating a straightforward and verified procedure that complies with green chemistry.

The Positive Impact of Vitamin C (Ascorbic Acid) Utilisation in Cancer Treatment: A Scoping Review of Published Articles From the Perspective of the in Vitro Studies

@#Survival benefit of patients with advanced cancer was reported with intravenous vitamin C administration. Nevertheless, a recent systematic review failed to support the clinically use of vitamin C in cancer patients due to the diversity of interventions and cancer type. This study aimed to provide a scoping review of vitamin C utilisation and its impact on cancer treatment from the perspective of in vitro studies. The review was conducted using predefined search terms in three scientific databases. 44 articles were retrieved with a total of 15 cancer types being studied from 2015 to 2020. The findings were classified into primary and secondary outcome. The primary outcome refers to chief consequences of vitamin C treatment, while the secondary outcome denotes the additional advantages generated as a result of the primary outcome, which occurs both in monotherapy and combination therapy. This review discussed the major mechanism of vitamin C as anti-cancer and its relation with the outcomes.

Long-term oral vitamin C administration improves cerebral microvascular vasodilatory impairment in diabetes: in vivo evidence using diabetic rats

Background: Many clinical reports have indicated that ascorbic acid (vitamin C) improves vasodilatory impairments in patients with diabetes mellitus, but there is very little in vivo evidence to demonstrate its effectiveness on the brain. Objective: To investigate long-term effects of oral vitamin C administration on the cerebral microvascular vasodilation in diabetes, using streptozotocin (STZ)-induced diabetic rats. Materials and methods: Diabetes was induced in male Wistar Furth rats by a single intravenous injection of STZ (55 mg/kg b.w). Ascorbic acid (vitamin C) was administered in drinking water (1g/l). The rats were divided into control and diabetic groups with or without administration of vitamin C. The cerebral microcirculation was observed at different times (12, 24 and 36 weeks) after vitamin C supplementation, using fluorescence videomicroscopy. Responses of cerebral arterioles to acetylcholine (ACh), adenosine-5 diphosphate (ADP) and nitroglycerine (NTG) were studied by measuring diameters of cerebral arterioles before and after topical application on the cortical surface. Results: The vasodilatory responses of cerebral arterioles to ACh and ADP were significantly decreased in diabetic rats, compared with non-diabetic (control) rats. The response to NTG was not altered in diabetic rats, indicating that the vasodilatory impairment involves at the endothelium. The impaired endothelium-dependent vasodilation was prevented by long-term vitamin C administration. Conclusion: Long-term oral vitamin C administration might be of clinical relevance in improving cerebral microvascular vasodilatory impairment in diabetes.