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Background: Osteoarthritis is the most common type of joint disease. It represents a heterogeneous group of conditions resulting in common histopathologic and radiologic changes. It is a degenerative disorder arising from biochemical breakdown of articular (hyaline) cartilage in the synovial joints.Methods: Total of 90 patients were randomly selected from outdoor and indoor of Orthopaedics department (IGIMS Patna). Study was done in Department of Pharmacology & Orthopaedics at IGIMS Patna. Three groups A, B and C were taken. Each group was consist of 30 patients of both sexes and age groups between 18 to 65 years. Group A was received Multivitamin with Exercise. Group B was received NSAIDS only. Group C was received Avocado oil orally along with Exercises as Muscle strengthening exercises of Quadriceps, Hamstrings, Abductor and Adductor muscles of thigh. We had compared pain thresholds among all these three groups with the help of Visual analogue scale and Oxford Knee score.Results: After 3 months of treatment the patients belonging to group C showed better response as compared to group A and B. When we compared pain threshold among group A, B and C on the basis of Oxford Knee score group C had occupied maximum score, which meant satisfactory joint functions and did not require any formal treatment. we also compared average visual analogue scale and average oxford knee score, Group C showed better response.Conclusions: Avocado oil is a food supplement and does not contain any side effects as compared to NSAIDS [Non-steroidal anti inflammatory drugs], glucosamine sulfate, chondroitin sulfate, sulfasalazine etc so avocado oil can be used for long duration in case of osteoarthritis.
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ABSTRACT: This study aimed to present a literature review about the characteristics, applications, and potential of avocado (Persea americana). Avocado is considered one of the main tropical fruits, as it contains fat-soluble vitamins which are less common in other fruits, besides high levels of protein, potassium and unsaturated fatty acids. Avocado pulp contains variable oil content, and is widely used in the pharmaceutical and cosmetics industry, and in the production of commercial oils similar to olive oil. This fruit has been recognized for its health benefits, especially due to the compounds present in the lipidic fraction, such as omega fatty acids, phytosterols, tocopherols and squalene. Studies have shown the benefits of avocado associated to a balanced diet, especially in reducing cholesterol and preventing cardiovascular diseases. The processed avocado pulp is an alternative to utilize fruits, which can be used in various value-added food products. Fluid extract of the avocado leaves is widely used in pharmaceutical products, mainly due to the diuretic characteristic of the present compounds in plant leaves. With the increasing research supporting the nutritional characteristics and benefits of avocado, the tendency is to increase the production and exploitation of this raw material in Brazil, as also observed in other countries.
RESUMO: Objetivou-se com este trabalho apresentar uma revisão da literatura sobre as características, aplicações e potencialidades do abacate (Persea americana). O abacate é considerado um dos principais frutos tropicais, pois possui as vitaminas lipossolúveis que, em geral, são deficientes nas outras frutas. Além destas, contém proteínas e elevados teores de potássio e ácidos graxos insaturados. Apresenta quantidade variável de óleo na polpa, sendo esta vastamente utilizada nas indústrias farmacêutica e de cosméticos, e na obtenção de óleos comerciais similares ao azeite de oliva. Esse fruto tem sido reconhecido por seus benefícios à saúde, especialmente em função dos compostos presentes na fração lipídica, como ácidos graxos ômega, fitoesterois, tocoferois e esqualeno. Estudos têm demonstrado os benefícios do abacate associado a uma dieta balanceada, principalmente, na redução do colesterol e na prevenção de doenças cardiovasculares. A polpa do abacate na forma processada é uma alternativa para aproveitar os frutos, passível de ser utilizada em diversos produtos alimentícios de maior valor agregado. O extrato fluido das folhas do abacateiro é muito utilizado em produtos farmacêuticos, principalmente, pelo caráter diurético de compostos presentes nas folhas da planta. Com o aumento das pesquisas que comprovam as características nutricionais e os benefícios do abacate, a tendência é aumentar a produção e exploração dessa matéria-prima no Brasil, como já acontece em outros países.
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Nanoemulsion is submicron sized emulsion typically in the range of 20-200 nm. Avocado oil is often used in herbal skin care. The aim of this study was to characterize nanoemulsion hydrogel prepared using avocado oil and sucrose ester stearate as surfactant. The nanoemulsion hydrogel were prepared by nanophase emulsification technique. These formulations were examined using zetasizer to determined the mean diameter of dispersed oil droplets, polydispersibility index (PDI) and zeta potential. Moreover viscosity of the prepared nanoemulsion hydrogel were studied. The results reveled that nanoemulsion prepared with 60% w/w oil, 24% w/w glycerol and 16% w/w surfactant showed droplets size below 200 nm with good polydispersibility index and zeta potential < - 30 mV. The optimum formulation of nanoemulsion was prepared in the form of nanoemulsion hydrogel using carbopols 934 and 940. The results of the viscometer for the nanoemulsion hydrogel showed that the storage modulus (G’) which describes the elasticity of the component were greater than the loss modulus (G”) values which reveals the viscosity of the component.
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Objective To explore the effects of natural avocado oil and olive oil on the proliferation and differentiation of HaCaT cells. Methods MTT assay was performed to determine the optimal work concentration of avocado oil and olive oil. Cultured HaCaT cells were divided into 3 groups, i.e., avocado oil group treated with avocado oil of 3% (v/v), olive oil group treated with olive oil of 3% (v/v), and control group without any treatment. Immunocytochemistry and immuno-dot-blot method were used to detect the expressions of c-myc, mitogen-activated protein kinase ( MAPK ), nuclear factor ( NF)-κB, filaggrin, involucrin and keratin10 in HaCaT cells. Results As immunocytochemistry showed, the mean grey values (staining intensity) of c-myc,MAPK, and NF-κB in HaCaT cells were 131.4 ± 6.6,136.3 ± 4.5 and 134.3 ± 5.2 respectively in the avocado oil group, 121.1 ± 4.5, 107.9 ± 7.3 and 106.4 ± 5.4 respectively in the olive oil group, significantly higher than that in the control group (101.9 ± 8.9,91.4 ± 5.1 and 94.3 ± 7.0, respectively, all P＜ 0.05), and the avocado oil group was higher than the olive oil group in all the above parameters (all P ＜ 0.05). Increased expressions of filaggrin, involucrin and keratin 10 were observed in the avocado oil group and olive oil group compared with the control group (all P＜ 0.05), and in the olive oil group than in the avocado oil group (all P＜ 0.05).The mean grey values of these proteins obtained by immunocytochemisty were significantly correlated with those obtained by immuno-dot-blot method in avocado oil group (r = 0.94, P ＜ 0.01 ) and olive oil group (r=0.97, P ＜ 0.01 ). Conclusions Certain concentrations of avocado oil and olive oil can promote the proliferation and differentiation of HaCaT cells; avocado oil is more capable to accelerate their growth and proliferation, and olive oil to enhance their differentiation.