RESUMEN
This study describes the natural poisoning of goats by Rhododendron simsii in Southern Brazil. Five of eight goats died after ingesting branches of plants, which were pruned and placed near the goats. Clinical signs observed were restlessness, shrill bleating, profuse regurgitation, looking and kicking at the flank, a loss of balance, irregular gait, staggering, and opisthotonos. At necropsy or histopathology affected goats had not showed lesions. Two goats were fed with 21.5g kg-1 bw and 30g kg-1 bw of fresh leaves of R. simsii. Both goats developed signs similar to those naturally affected goats. These findings indicated that R. simsii is highly toxic and lethal to goats.
Descreve-se um surto de intoxicação espontânea por R. simsii em caprinos no sul do Brasil. Cinco de oito cabras morreram após a ingestão da planta que foi podada e colada no local onde estavam os caprinos. Os sinais clínicos caracterizam-se por excitação, balidos estridentes, regurgitação, coicear o flanco, desequilíbrio e opistótono. Não foram observadas lesões macroscópicas e histológicas nos animais necropsiados. Dois animais receberam doses de 21,5 e 30g kg-1 de folhas verdes de R. simsii. Ambos desenvolveram sinais clínicos similares aos animais intoxicados espontaneamente. Esses achados indicam que R. simsii é altamente tóxica e letal para caprinos.
RESUMEN
Objective: To study the inclusion effect and rules of azalea oil (rhododendron anthopogonoides marxim) and ? cyclodextrin(? CYD) in different proportion. Methods: An optimal condition for the preparation of the azalea oil ? CYD was established by orthogonal test. Results: The optimal condition was that stiring, 30 ?C , 30min, ? CYD:oil=8g∶1mL Conclusion: This optimized process is simple, stable and efficient.
RESUMEN
The toxic effect of azalea extract, especially on cardiovascular system, in relatively unclear. The purpose of this study is to study the possible underlying mechanism and effect of toxic ingredient of azalea on cardiovascular system. The 71 healthy rabbits were divided into 10 groups: In group as preliminary study; 4 cc of normal saline was administered intravenously (N); 0.7 gm/kg and 1.0 gm/kg of azalea extract was administered respectively in the same route, volume (A1, A2); atropine was administered intravenously (A); after pretreatment with atropine (0.04 mg/kg) to block parasympathetic system, azalea extract was injected like the above groups (AA1, AA2); normal saline, 0.7 gm/kg and 1.0 gm/kg of azalea extract were administered respectively with 0.2 cc (1:1000) epinephrine (E0, E1, E2). We measured the following indices at I minute interval during first 10 minutes and then 10 minute interval during next 30 minutes: RR interval, QTc interval, maximal systolic and diastolic pressure drop with occurring time and presence of significant arrhythmia. The results were as follows: 1. The changes of RR interval, QTc interval were significantly increased in groups by Azalea extract. The blood pressure change was significantly decreased in groups by Azalea extract. There were no significant differences according to dosage of Azalea extract. 2. The changes of RR interval, blood pressure were significant differences between administration of atropine and Azalea extract after pretreatment with atropine, but not in the change of QTc interval. 3. There were no significant differences in the change of RR interval, ATc interval, blood pressure drop according to pretreatment with atropine. 4. The interaction between epinephrine and Azalea extract was not noted by the effect of epinephrine itself. 5. The ST change by 0.7 gm/kg, 1.0 gm/kg of Azalea extract was revealed in 1 case (14.0%), 7 case (100%), respectively. 6. Most of all cases with arrhythmia, ventricular tachycardia, ventricular fibrillation, were noted in the group by epinephrine, except on case by Azalea extract (1.0 gm/kg). It was idioventricular rhythm. In conclusion, azalea extract has negative inotropic and chronotropic effect with arrhythmogenic potential possibly through direct myocardial ischemia or injury but we can't be absolutely exclusive of actions of autonomic nervous system, especially parasympathetic nervous system.