RESUMEN
To introduce germfree isolating technologies used in gnotobiology , and to compare the differences with in Cleaning Rooms, Restrictive Access Barrier Systems (RABS) and Isolators.To expect the development of isolators , and to describe the uses of isolators in gnotobioly .
RESUMEN
OBJECTIVE To ensure all relative environmental indications achieving stabilization in both animal test region and breeding area in the barrier system by enhancing infection management in animal laboratory.METHODS Standard nosocomial infection management in the animal laboratory was taken strictly and adapted standard management and attendance to the clean-air system;constructed and perfected all the regulations and managements of the barrier facility,taken a series of sterilization measurement in SPF area,and performed standard operating procedure of the airflow,human-being flow,material flow and animal flow strictly.RESULTS Since the barrier system in animal laboratory had been built and used for more than two years,every monitor index including temperature,humidity,ventilation time,airflow velocity,pressure grade,falling bacteria,noises et al,had achieved national standards.CONCLUSIONS Powerful and effective management can guarantee environment keeping cleaning and animal quality standard in the barrier system.
RESUMEN
In this review the author scrutinizes the effects of exercise on the immune system on two points. One is the effect of usual proper exercise on the immune system, and the other is the acute effect of intense exercise on the immune system. Concerning the first point, exercise augments physiological activities such as circulation, metabolism and physiological regulatory systems. These effects cause augmentation of the defense mechanisms, i.e. fortification of barrier systems, increases in the number of cells in the immune system and augmentation of cell migration and potentiation of cytokine production. As a result, daily exercise habits show prophylactic effects against infection, improvement in predisposition and depressed immunosuppression by senescence. Concerning the second point, acute intense exercise triggers activation of the hypothalamus-pituitary-adrenal (HPA) axis, and, as a result, the immune response is suppressed by corticosteroid. Moreover, intense exercise induces harmful factors which suppress the immune system. Proper daily exercise is, therefore, recommended to maintain the immune system in good condition.