Biocompatability of carbon nanotubes with stem cells to treat CNS injuries / 대한해부학회지

Cases reporting traumatic injuries to the brain and spinal cord are extended range of disorders that affect a large percentage of the world's population. But, there are only few effective treatments available for central nervous system (CNS) injuries because the CNS is refractory to axonal regeneration and relatively inaccessible to many pharmacological treatments. The use of stem cell therapy in regenerative medicine has been extensively examined to replace lost cells during CNS injuries. But, given the complexity of CNS injuries oxidative stress, toxic byproducts, which prevails in the microenvironment during the diseased condition, may limit the survival of the transplanted stem cells affecting tissue regeneration and even longevity. Carbon nanotubes (CNT) are a new class of nanomaterials, which have been shown to be promising in different areas of nanomedicine for the prevention, diagnosis and therapy of certain diseases, including CNS diseases. In particular, the use of CNTs as substrates/scaffolds for supporting the stem cell differentiation has been an area of active research. Single-walled and multi-walled CNT's have been increasingly used as scaffolds for neuronal growth and more recently for neural stem cell growth and differentiation. This review summarizes recent research on the application of CNT-based materials to direct the differentiation of progenitor and stem cells toward specific neurons and to enhance axon regeneration and synaptogenesis for the effective treatment of CNS injuries. Nonetheless, accumulating data support the use of CNTs as a biocompatible and permissive substrate/scaffold for neural cells and such application holds great potential in neurological research.

Study on compatibility of the nHA/PA composite implant / 重庆医科大学学报

Objective: To evaluate the compatibility of the nHA/PA composite implant. Methods: The component was implanted into the proximal humeral metaphysis of rabbits. The prosthetic humeral head replacement was performed in 20 rabbits. The rabbits were killed at the 3rd, 6th, 12th, 24th week after operation. Specimens were observed by histology and immunohistochemitry. Results; Immuno-histochemistry results showed that there were some CD4+ , CD8+ lymphocytes infiltrated into the interface at the 3rd week, without other inflammatory cells being observed. While at 6th, 12th, 24th week, neither lymphocytes nor inflammatory cells were seen. Conclusion; The nHA/PA prostheses show good biocompatibility.