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Objective:To establish a blood consumption prediction model for emergency trauma patients based on machine learning algorithm, so as to guide blood collection and blood supply institutions to prepare for the early blood demand of mass casualties in public emergencies.Methods:A retrospective analysis was conducted on trauma patients in the emergency system database of 12 hospitals in Zhejiang Province from January 2018 to December 2020. Patients with chronic medical history such as hematological diseases and tumors, and transferred from other hospitals after external treatment were excluded. The patients were divided into the transfusion group and non-transfusion group according to whether they received blood transfusion. The differences in demographic and clinical characteristics between the two groups were compared, and the computer learning algorithm (XGBoost) was used to build the blood consumption prediction model and blood consumption volume prediction model of emergency trauma patients.Results:Totally 2025 patients were included in this study, including 1146 patients in the transfusion group and 879 patients in the non-transfusion group. The blood demand of emergency trauma patients mainly occurred within 3 days of admission (60%). The main variables affecting the blood consumption prediction model of emergency trauma patients were shock index, hematocrit, systolic blood pressure, abdominal injury, pelvic injury, ascites and hemoglobin. Compared with the traditional prediction model, XGBoost model had the highest hit rate of 59.0%. The accuracy of blood consumption prediction model was the highest when seven levels of blood volume were adopted, and the deviation fluctuated between [0~1] U. According to the prediction model, the blood consumption prediction formula was∑ nw× c. Conclusions:The preliminarily constructed prediction model of blood transfusion and blood consumption for emergency trauma patients has better performance than the traditional prediction model of blood transfusion, which provides reference for optimizing the decision-making ability of blood demand assessment of hospitals and blood supply institutions under public emergencies.
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Las transfusiones sanguíneas son un componente fundamental de la atención sanitaria, y la necesidad de un acceso equitativo a la sangre segura es universal. En varias resoluciones la organización Mundial de la Salud, OMS, ha instado a los países miembros a reforzar los programas de seguridad sanguínea. El contar con donantes voluntarios no remunerados es una medida estratégica fundamental para garantizar la seguridad, calidad, disponibilidad y accesibilidad de las transfusiones sanguíneas. Otros elementos importantes son las pruebas de calidad garantizada a toda la sangre donada, el uso adecuado de la sangre para reducir al mínimo las transfusiones innecesarias y los riesgos que conllevan, así como los procedimientos clínicos seguros de transfusión. La Caja Costarricense de Seguro Social, CCSS ha trabajado en las diversas áreas para fortalecer la seguridad sanguínea en el país, y por ende, el programa de sangre segura. Los primeros donantes voluntarios se registran hasta el año 1998...
Blood transfusions are a fundamentalcomponent of sanitary attention,and the necessity of an equitableaccess to safe blood is universal. Inseveral resolutions the World HealthOrganization (WHO) has urged tothe member countries to reinforce theprograms of blood security. Havingno remunerated voluntary donors is astrategic measurement fundamentalto guarantee the security, quality,availability and accessibility of bloodtransfusions. Other important elementsare the tests of guaranteed quality to alldonated blood, the proper use of bloodto reduce the unnecessary transfusionsand the irrigations that entail minimumas well as the safe clinical proceduresof transfusion. The social security of Costa Rica has worked in diverse areas to fortify blood security in the country and the program of safe blood. The firstvoluntary donors register was untilyear 1998 (22,896, corresponding to40% of total donors). Most donationscame from replacement donors; beingit the tendency until year 2003; whenthe type of collected donations wasinverted, 51% of voluntary donationand 49% of replacement, until obtaining59% in 2005. The coverage of screening for VIH, VHB, VHC was 100%, but not for the Disease of Chagas and HTLVI/II that reached 100% until year 2002, and forCore of Hepatitis B, it happened untilyear 2005. One inquire that the number of transfusions has been reduced inrelation to the average from year 2001,and since a greater division of unitsis made until reaching 92% in year2005. Regarding screening tests and theparticipation in the external controlof quality, it is observed a correlationof 100% for the VHI results, 99%of correlation for the VHC with afalse positive in year 2002, and falsenegative in year 2006 for HBsAg.
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Sangre , Bancos de Sangre , Análisis Químico de la Sangre , Donantes de Sangre , Costa RicaRESUMEN
Objective To analyze influence for structure and function of plasma through methylene blue method (MB) in the procedure of virus inactivation.Methods 30 fresh plasma,which were adopted through 400 ml bloods in 6 hours,were choosed randomly and connected with sterile filter with MB. The density of MB was approximately 0.9 ~ 1.3 mol/L. Blood plasma with added MB was placed into the shelf of 4 ℃ virus inactivation and shakem frequently 60 meta /min. Temperature was kept in 4 ℃ within 35min.MB and residual leukocytes were filtered by apparatus of virus inactivation. The surplus of 10 ml blood plasma was immediately placed in -80℃ refrigerator. Concentration of MB,FⅧ:C,FⅤ:C,VWF,Fib of plasma samples was tested before and after virus was inactivated.Results Recovery rates of the volume of plasma,FⅧ:C,FⅤ:C,VWF,Fib respectively were(97.29?2.03)%,(81.43?11.15)%,(80.12?14.03)%,(92.48?8.35)% and (82.86?19.13)% after virus was inactivated through methylene blue method.Conclusion Quality of blood plasma through inactivation of virus with methylene blue method was consistent with national standard and could satisfy clinical need in the precondition of blood safety.There was less influence for blood plasma component.