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Introduction: Diabetes is a major public health problem that is approaching epidemic propor?ons globally. Selfmonitoring of blood glucose (SMBG) by the American Diabetes Associa?on (ADA) is promoted in diabe?c pa?ents so that they achieve and maintain specific glycemic goals. Objec?ves : To compare the blood glucose es?ma?on methods; capillary blood and venous blood by glucometer, venous plasma glucose es?ma?on by auto analyzer and to find varia?on in results. Material & Methods : 60 pa?ents a?ending Outpa?ent department of JIIUs IIMSR and Noor hospital, Warudi, Badnapur, Maharashtra who were advised blood glucose es?ma?on were selected. Finger prick (capillary) blood glucose & glucose es?ma?on of venous blood was done by glucometer; and venous plasma glucose es?ma?on was done by auto analyzer in laboratory. Result & Conclusion : Mean values of capillary glucose es?ma?on by glucometer were higher than plasma glucose es?ma?on in laboratory on auto analyzer and the difference was found to be sta?s?cally significant. Venous glucose es?ma?on on glucometer gave high erroneous results as compared to plasma glucose es?ma?on in laboratory.
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Objective To investigate the rates of undernutrition and nutritional risks of surgical pa-tients with pancreatic tumors .Methods Totally 121 surgical patients with pancreatic tumors from Depart-ment of Surgery Beijing Hospital were enrolled in a prospective study during January 2014 to December 2015 . Patients were divided into two groups:the pancreatic cancer group ( n=90 ) and other pancreatic tumor group ( n=31 ) .Nutritional Risk Screening 2002 was used to assess the nutritional status .Other data including an-thropometric measure, body composition, blood biochemistry and clinical outcome were collected and ana-lyzed.Results Among 121 patients, the mean age was ( 61.9 ±13.6 ) years, the mean body mass index was ( 23.20 ±2.95) kg/m2 , the mean mid-upper circumference was ( 28.8 ±3.5 ) cm, the mean muscle weight was (44.6 ±7.4) kg, and the mean fat mass was (16.8 ±7.6) kg .There was no significantly differ-ence in anthropometric measurement results and body compositions between two groups ( all P>0.05 ) .In the pancreatic cancer group, albumin [ (39.0 ±4.7) g/L vs. (42.3 ±2.9) g/L, P<0.001], total protein [ (62.8 ±6.2) g/L vs.(66.3 ±2.9) g/L, P<0.001], and prealbumin [ (136.1 ±85.4) mg/L vs. (197.8 ±112.6 ) mg/L, P=0.011 ] were significantly lower than those in the other pancreatic tumor group and a higher fasting blood-glucose [ (6.45 ±2.47) mmol/L vs.(4.95 ±0.79) mmol/L, P<0.011] was found.Among all patients , the rates of undernutrition and nutritional risk were 4.1% and 78.5%, and the pancreatic cancer group had a higher rate of nutritional risk (91.1% vs.38.7%,χ2 =36.525, P<0.001). Conclusion In this prospective study , surgical patients with pancreatic cancer have a high incidence of nutri -tional risk, with low protein level and abnormal glucose metabolism .
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AIM:TodetecthemoglobinA1c(HbA1c)andparametersofbloodglucosefluctuationinChinesenewlydiag-nosed type 2 diabetes mellitus (T2DM) patients, and further to specify the factors that were related to mean blood glucose (MBG) in this population.METHODS:Newly diagnosed T2DM patients (n=90) from 4 hospitals in Guangdong province were enrolled, and subjected to 3 d continuous glucose monitoring (CGM) after testing for HbA1c and other laboratory tests.Blood glucose data collected during CGM were used to calculate MBG and parameters of blood glucose fluctuation.RESULTS: Correlation analysis revealed that MBG was significantly related to all parameters of blood glucose fluctuation, HbA1c, fast plasma glucose ( FPG) and 2 h postprandial glucose (P<0.01), but not to sex, age or blood lipid profile.Further analysis utilizing step-wise general linear model showed that HbA1c, absolute means of daily difference ( MODD) , difference between maximal and minimal glucose ( DMMG) and FPG had the strongest relation to MBG.CONCLUSION: Factors affecting MBG of the newly diagnosed T2DMpatients in our country include HbA1c, FPG, DMMG and MODD, and thus it may be prone to misleading results that only HbA1c is applied to estimate MBG in this population.
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[ABSTRACT]AIM:ToinvestigatetheeffectofimmunosuppressantFK506onserumglucoseinratsandtoex-plore its mechanism .METHODS: Sprague-Dawley rats ( n =12 ) were randomly divided into drug group and normal group.The rats in drug group were intraperitoneally injected with FK 506 at dose of 1 mg· kg-1 · d-1 and the rats in nor-mal group received saline (1 mL· kg-1 · d-1 , ip) for 14 d.The fasting weight and fasting glucose were regularly meas-ured every 2 d.Visceral fat was isolated from the rats at the end of experiment .The mRNA expression of adiponectin , lep-tin, visfatin, resistin, retinol-binding protein 4 ( RBP4) and peroxisome proliferator-activated receptors γ( PPAR-γ) was determined by real-time fluorescence quantitative PCR .The protein expression of PPAR-γand adiponectin was measured by Western blotting .RESULTS:Compared with normal group , the concentration of fasting blood glucose in model group was significantly increased from the 10th day (P<0.05).At day 14, the fasting blood glucose of the model group increased from (5.10 ±0.62) mmol/L to (7.73 ±0.73) mmol/L.No significant change of blood glucose in normal group between the 10th day and the 14th day [from (4.66 ±0.32) mmol/L to (5.80 ±0.10) mmol/L] was observed.Compared with normal group , the mRNA expression of PPAR-γ, adiponectin and leptin in the adipose tissue of model group was signifi-cantly decreased ( P <0.01 ) , whereas the expression of visfatin , resistin and RBP4 was significantly increased ( P <0.05).Compared with normal group, the expression of PPAR-γand adiponectin in model group was decreased (P <0.01).CONCLUSION:FK506 may decrease the expression of PPAR-γto change the expression of adipocytokines and induce hyperglycemia in rats .
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Objective To explore the effect of self-management health education on promoting the medical compliance of patients with metabolic syndrome. Methods Fifty-six patients with metabolic syn-drome were divided into the observation group and the control group at random, with 28 patients in each group. The self-management health education was only given to the observation group, the control group was given rou-tine instruction. After three months, the patients' medical compliance and the ecological parameters (fasting blood glucose, 2 hours' postprandial blood glucose, glycosylated hemoglobin, triglyceride) were tested, the re-suits went through χ2 test and t test. Results The observation group had a better medical compliance than that of the control group, and the biochemieal parameters were greatly alleviated. Conclusions Nursing inter-vention is an ef-feetive measure to improve the medical compliance of patients with metabolic syndrome.
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Astragalus polysaccharide (APS)was applied to treat rat model of type 2 diabetes mellitus.Blood glucose and insulin, the activity of PKB/Akt and translocation of GLUT4 in skeletal muscle of rats were examined. Results showed that AIMS decreased blood glucose, which may be related with increasing sensitivity of insulin, activity of PKB/Akt and transloeation of GLUT4 in the skeletal muscle tissue.
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Objective To explore the effects of high insulin and high glucose concentrations on glucose transport activity,the expression of insulin signaling peptides and glucose transporter 4(GLUT4) translocation in primary cultured rat adipocytes.Methods Isolated rat adipocytes were cultured for 24h at insulin(10 4?U/ml) and different concentration glucose(5,10,15 and 25mmol).Then the glucose uptake,cellular contents of insulin receptor substrate(IRS) 1/2,phosphatidylinositol 3-kinase 85 subunit(p85),protein kinase B(PKB) and GLUT4 were measured by Western blotting method.Results These adipocytes treated with insulin and different high concentration glucose had shown to impair glucose uptake in a dose-dependent manner,inhibited cellular IRS1 expression,impaired IRS2 protein expression independent on glucose concentration in the medium,it did not influence the contents of p85,PKB and GLUT4,but decreased GLUT4 translocation.Conclusions Chronic high insulin induced insulin resistance may be caused by the increasing glucose concentration surrounding the cells.The mechanism may be involved in affecting IRSs protein expression and GLUT4 translocation.
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Objective To study relationship between blood-glucose change and prognosis of the patients after severe traumatism.Methods 70 cases severe traumatic emergency patients selected tested the level of blood-glucose instantly when they presented themselves to the clinic after injury,used saccharimether and blood-glucose test paper provided by the Johnson Limited Corporation,and 30 slight traumatic emergency patients at the same time were selected as contrel.Result The blood-glucose after severe traumatic were markedly higher than that of slight traumatic group,which have significance(P
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In this study, we evaluated the effects of fentanyl, midazolam, and fentanyl-midazolam on cardiovascular system and blood glucose during endotracheal intubation in forty normotensive patients scheduled for elective surgery under general anesthesia. The patients were randomly classified into four groups; Group I (control) received tracheal intubation with thiopental 5 mg/kg (n=10), group II received tracheal intubation with fentanyl 6 ug/kg followed by thiopental 2 mg/ kg (n=10), group III received tracheal intubation with midazolam 0.3 mg/kg (n=10), group IV received tracheal intubation with fentanyl 4 ug/kg followed by midazolam 1 mg/kg (n=10). The changes of systolic blood pressure, diastolic blood pressure, mean arterial blood pressurie, heart rate, and blood glucose were compared in each group. The results were as follows; 1) In group I, endotracheal intubation caused a significant rise in SBP, HR and blood glucose. 2) In group II, endotracheal intubation caused little changes in SBP, DBP,MAP and blood glucose but HR was rised. 3) In group III, endotracheal intubation caused little changes in SBP, DBP, MAP, HR and blood glucose. 4) In group IV, endotracheal intubation caused little changes in SBP, DBP, MAP, HR and blood glucose.
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Humanos , Anestesia General , Glucemia , Presión Sanguínea , Sistema Cardiovascular , Fentanilo , Frecuencia Cardíaca , Intubación , Intubación Intratraqueal , Midazolam , TiopentalRESUMEN
Objective To observe the effect of the spleen-strengthening and qi-invigorating herbal medicines on insulin mediator in type 2 diabetic rats with spleen-qi deficiency syndrome.Methods Rat models were induced by intraperitioneal injection of streptozocin (STZ),overstrain,abnormal meals with greasy foods.Model rats were randomly allocated to two groups:Group A was treated with herbal medicine with the actions of strengthening spleen and invigorating qi;Group B was treated with purified water.The normal rats were allocated to the control group.The serum contents of fasting blood-glucose and insulin were observed before and after 3-week treatment.The content of hepatic cell-membrane insulin mediator was observed after 3-week treatment.Results After 3 weeks of treatement the serum contents of fasting blood-glucose were decreased and the sensitivity of serum insulin were increased in Group A as compared with those before treatment (P
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0.05).The two-week administration of Jianpi Recipe decreased the bloodglucose of diabetic mice.Normal saline had no obvious influence on it.Time-choosing recipe administration could adjust the circadian rhythm of bloodglucose concentration.Administration at 6am was more effective in adjusting bloodglucose rhythm.Conclusion Spleen-reinforcing therapy can decrease the bloodglucose of diabetic mice,and the effect tend to be more obvious with the administration prolonging.Administration at different time exerts different effect on circadian rhythm of bloodglucose concentrations.There exists different effect in different time administration in spleen-reinforcing therapy.
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We selected at random 30 normotensive patients who had received operation under the general anesthesia with intubation at Chungnam national university hospital. They were divided into 3 groups. group I (Control) had received tracheal intubation with thiopental 5mgkg-1. (n=10), group II had received tracheal intubation with fentanyl 15 ugkg-1. (n=10), group III had received tracheal intubation with fentanyl 15ugkg-1 and diazepam 0.05mgkg-1 (n=10). The changes of systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial blood pressure (MAP), heart rate (HR), and blood sugar were compared in each group. The results were as follows: 1) In group I, endotracheal intubation caused a significant riae in SBP(p<0.01) and blood glucose (p<0.01). 2) In group Il, endotracheal intubation caused a significant rise in SBP (p<0.05) and blood glucose (p<0.01). 3) In group III, endotracheal intubation cauaed little changes in SBP, DBP, MAP, HR and blood glucose.