Relationship between weight change and the changes in blood pressure, blood glucose and blood lipid profiles in middle-aged and elderly Chinese people: a cohort study / 中华预防医学杂志

Objective@#To explore the relationship between weight change and the changes in blood pressure, blood glucose and blood lipid profiles in middle-aged and elderly Chinese people.@*Methods@#All participants were from the Dongfeng-Tongji cohort study. The study included 16 606 middle-aged and elderly Chinese people with complete information in the baseline survey in 2008 and the first follow-up survey in 2013. We collected the data on demographic characteristics, lifestyle, history of diseases and medication, and the results of medical health examinations, including height, weight, blood pressure, fasting blood glucose and lipid profiles. We divided the weight change into five groups, moderate or above weight loss (<-8.0%), slight weight loss (-8.0%, -3.1%), weight maintenance (-3.0%, 3.0%), slight weight increased (3.1%, 8.0%), and moderate or above weight increased (>8.0%). Generalized linear regression model was used to analyze the relationship between weight change and the changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG). Subgroup analyses were used to explore the influences of gender, age and baseline BMI level on the relationship between weight change and the above-mentioned metabolic indicators.@*Results@#The average age of participants in baseline survey was (62.19±7.28) years with a range of 45 to 89 years. During the five-year period, there were 18.86% (2 633), 28.03% (4 655), 35.87% (5 956), 13.96% (2 319), 6.28% (1 043) people with moderate or above weight loss, slight weight loss, weight maintenance, slight weight increased, and moderate or above weight increased, respectively. Regression analyses showed that body weight change were positively correlated with changes in SBP, DBP, FBG, TC, LDL-C and TG, and negatively correlated with change in HDL-C (all linear trend P values were<0.05); As every 10% of weight changed, the β (95%CI) of changes in SBP (mmHg) (1 mmHg=0.133 kPa), DBP (mmHg), FBG (mmol/L), TC (mmol/L), LDL-C (mmol/L), HDL-C (mmol/L) and TG (mmol/L) were 4.94 (4.32, 5.55), 2.50 (2.11, 2.88), 0.05 (0.02, 0.08), 0.13 (0.11, 0.16), 0.14 (0.12, 0.16), -0.05 (-0.07, -0.04) and 0.16 (0.14, 0.18), respectively. Furthermore, subgroup analyses showed that weight change can lead to greater changes in blood pressure in older and overweight or obesity elderly people (all P for interaction<0.05).@*Conclusion@#Weight loss was beneficial for middle-aged and elderly people to improve the blood pressure, blood glucose and blood lipid profiles, regardless of the weight at the baseline, while weight gain was not.

Relationship Between the Changes of Plasma Levels of Resistin With the Contemporary Body Weight Changes in the Same Population / 中国循环杂志

Objective: To explore the relationship between the changes of plasma levels of resistin with the contemporary body weigh changes in the same population. Methods: The community based epidemiological surveys were carried out in the same population in Shijingshan district of Beijing at the year of 2005 and year of 2010. A total of 943 subjects with the entire information of cardiovascular related risk factors were enrolled including 316 male with the mean age of (58.2 ± 8.5) years and 627 female with the mean age of (59.3 ± 7.5) years. Plasma levels of resistin in both year of 2005 and year of 2010 in all subjects were recorded, and the subjects were divided into 4 groups based on the quartile levels of resistin. Group①, the subjects with plasma level of resistin ≤ (-0.66) mmol/L,n=239, Group②, resistin level (from -0.67 to 0.25) mmol/L,n=233, Group③, resistin level (0.26-1.24) mmol/L, n=235 and Group④, resistin level ≥1.25 mmol/L,n=236. Pearson correlation study with uni- and multi- regression analysis were conducted to investigate the relationship between the changes of plasma levels of resistin with the contemporary body weight changes in the same population.Results: The uni-variate analysis showed that in female subjects, plasma levels of resistin were obviously related to the percentage (%) of body weight changes (correlation coefifcient: 0.1173), body weight index (kg/m2) changes (0.1521), the% of body weight index changes (0.1412), the waist circumference (cm) changes (0.1228) and the % of waist circumference changes (0.1057) respectively, allP0.05. Multi-regression analysis indicated that with adjusted baseline variables, in female subjects, the plasma levels of resistin were obviously related to body weight (kg) changes and the % of body weight changes (regression coefifcient: 0.0261 and 0.2916), body weight index (kg/m2) changes and % of body weight index changes (0.2157 and 0.3072), the waist circumference (cm) changes and the% of waist circumference changes (0.0532 and 0.2738) respectively, allP0.05. Conclusion: The changes of plasma levels of resistin are signiifcantly related to contemporary body weight changes in female subjects, but not in male subjects.

Risk Factors for Rickets of Prematurity in Extremely Low Birth Weight Infants

PURPOSE: This study aimed to analyze the risk factors for the development of rickets of prematurity in extremely low birth weight (ELBW) infants. METHODS: We retrospectively reviewed the data of 57 ELBW infants. Nineteen infants were diagnosed with rickets and 38 infants without rickets were recruited. On radiologic evaluation, 47% of infants had grade I, 37% had grade II, and 16% had grade III rickets. RESULTS: In ELBW infants with rickets, the durations of oxygen administration, mechanical ventilation, parenteral nutrition, and hospitalization were significantly longer compared to those of the control group. The number of days for achieving an enteral caloric intake of 80 kcal/kg/d and the number of days for regaining birth weight were significantly longer compared to those of the control group. Serial weight changes from birth weight during 8 weeks after birth was significantly lower in the rickets group than in the control group. Retinopathy of prematurity was significantly higher in the rickets group than in the control group. After adjustment for birth weight, rickets of prematurity was correlated with days for regaining birth weight (odds ratio [OR], 1.316; P=0.010), and with weight changes from birth weight at 4 weeks of age (OR, 0.964; P=0.033). CONCLUSION: In ELBW infants, the risk factors for rickets of prematurity were days for regaining birth weight from birth and the weight changes at 4 weeks of age. Early aggressive nutrition for regaining birth weight earlier may reduce the development of rickets of prematurity.

Confiabilidad y validez de constructo de la Escala de Modificación Corporal en varones adolescentes / Reliability and constuct validity of the Body Modification Scale in adolescent males

En diversos países se ha constatado no sólo la adopción de estrategias de cambio corporal por parte de los varones, sino que éstas pueden responder a distintas intenciones: perder peso, ganar peso e incrementar tono o masa muscular. Sin embargo, son escasos los instrumentos que permiten evaluar diferencialmente estos aspectos. Por tanto, el propósito de esta investigación fue obtener una versión en español de la Body Modification Scale (BMS), así como examinar sus propiedades psicométricas en varones adolescentes. El primer estudio comprendió la traducción, adaptación y aplicación piloto de la BMS; la consistencia interna y estructura factorial fue evaluada con 270 adolescentes (Medad=12.84), de los cuales 171 participaron en el retest. El segundo estudio se dirigió a probar, en una muestra independiente (n=200; Medad=13.46), la adecuación de la estructura factorial derivada respecto a la original. La versión en español de la BMS mostró tener adecuada consistencia interna (α=.88) y confiabilidad test-retest (r=.80). El análisis factorial exploratorio derivó inicialmente cuatro factores, observándose traslapamiento conceptual entre dos de ellos; por tanto, se optó por replicar el análisis forzando la extracción a tres factores. Éstos explicaron 44.1% de la varianza, agrupando 20 de los 24 reactivos originales. Los factores perder peso y aumentar tono o masa muscular mostraron adecuada confiabilidad (α>.86; r>.80), resultando sustancialmente menor la del factor ganar peso (.63 y .74, respectivamente). Los análisis factoriales confirmatorios fundamentaron la adecuación de ambas estructuras; sin embargo, el modelo correspondiente a la aquí propuesta mostró un mejor ajuste. En general, la versión en español de la BMS mostró poseer adecuadas propiedades psicométricas en varones adolescentes. Sin embargo, esto deberá corroborarse no sólo en otras edades, sino también en mujeres.

Several countries have noticed not only the adoption of body change strategies by males, but these may respond to different purposes: weight loss, weight gain and increased muscle tone or muscle mass. Nevertheless, instruments that allow the assessment of these aspects in a differentially way are scanty. Therefore, the aim of the present study was to obtain the Spanish version of the Body Modification Scale (BMS), as well as to examine its psychometric properties in adolescent men. The first study included the translation, adjustment and piloting of the BMS; internal consistency and factor structure were evaluated with 270 adolescents (Mage=12.84); 171 of them participated in retest. The second study was conducted to prove, in an independent sample (n=200; Mage=13.46), the adequacy of the factor structure derived from the original. The Spanish version of the BMS indicated to have adequate internal consistency (α=.88) and test-retest reliability (r=.80). The exploratory factor analysis derived initially four factors, showing conceptual overlap between two of them; therefore, it was opted to replicate the analysis performing an extraction to three factors. These explained 44.1% of the variance, grouping 20 of the 24 original items. The loss weight and increased muscle tone or muscle mass factors showed adequate reliability (α>.86; r>.80), resulting substantially lower the weight gain factor (.63 and .74, respectively). The confirmatory factor analysis supported the adequacy of both structures; however, the model here proposed showed a better fit. In general, the Spanish version of the BMS showed adequate psychometric properties in adolescent men. Nevertheless, this should be corroborated not only in other ages, but also in women.

Effect of $\beta$_{3}-Adrenergic Receptor Gene Polymorphism on Body Weight Change in Middle-Aged, Overweight Women

Objectives: To examine the effects of β3-adrenergic receptor gene polymorphism on body weight change during a weight reduction program for middle-aged, overweight women with careful consideration of their energy intake and expenditure. Methods: Design: Intervention study of weight reduction for 12 weeks in a community setting. Subjects: Eighty overweight middle-aged women who completed the individualized lifestyle modification program. Measurements: β3-adrenergic receptor gene polymorphism was identified by polymerase chain reaction and consecutive restriction fragment-length polymorphism analysis. Anthropometrical parameters, lifestyle factors, blood lipid and glucose levels, physical activity level and energy intake were measured before and at the end of the program. Results: The numbers of subjects with the Trp64Trp, Trp64Arg, and Arg64Arg genotypes were 45, 30 and 5, respectively. Baseline characteristics among subjects with the Trp64Trp, Trp64Arg and Arg64Arg alleles did not differ. After 12 weeks, the subjects with the 64Arg allele had significantly smaller decrease in body weight and energy intake than those without the 64Arg allele. The change of other clinical characteristics did not differ between the two groups. After adjusting for the %change of energy intake, the %change of body weight did not differ between the two groups. Conclusion: The 64Arg allele of the β3-AR gene is not likely to be the factor determining the difficulty in losing body weight in Japanese middle-aged, overweight women. Lifestyle factors, such as the decrease in energy intake, might mask the effect of the 64Arg allele on body weight loss. Specific considerations for the management of energy intake would be needed to promote body weight loss for those with the 64Arg allele.

Effect of β(3)-adrenergic receptor gene polymorphism on body weight change in middle-aged, overweight women

<p><b>OBJECTIVES</b>To examine the effects of β(3)-adrenergic receptor gene polymorphism on body weight change during a weight reduction program for middle-aged, overweight women with careful consideration of their energy intake and expenditure.</p><p><b></b>METHODS</p><p><b>DESIGN</b>Intervention study of weight reduction for 12 weeks in a community setting.</p><p><b>SUBJECTS</b>Eighty overweight middle-aged women who completed the individualized lifestyle modification program.</p><p><b>MEASUREMENTS</b>β(3)-adrenergic receptor gene polymorphism was identified by polymerase chain reaction and consecutive restriction fragment-length polymorphism analysis. Anthropometrical parameters, lifestyle factors, blood lipid and glucose levels, physical activity level and energy intake were measured before and at the end of the program.</p><p><b>RESULTS</b>The numbers of subjects with the Trp64Trp, Trp64Arg, and Arg64Arg genotypes were 45, 30 and 5, respectively. Baseline characteristics among subjects with the 64Arg allele had significantly smaller decrease in body weight and energy intake than those without the 64Arg allele. The change of other clinical characteristics did not differ between the two groups. After adjusting for the %change of energy intake, the %change of body weight did not differ between the two groups.</p><p><b>CONCLUSION</b>The 64Arg allele of the β(3)-AR gene is not likely to be the factor determining the difficulty in losing body weight in Japanese middle-aged, overweight women. Lifestyle factors, such as the decrease in energy intake, might mask the effect of the 64Arg allele on body weight loss. Specific considerations for the management of energy intake would be needed to promote body weight loss for those with the 64Arg allele.</p>