RESUMEN
Objective To observe the clinical efficacy of modified Chaihu Shugan powder in the adjuvant treatment of biliary acute pancreatitis.Methods A total of 40 cases of biliary acute pancreatitis were selected from June 2011 to October 2016 in the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine.The patients were randomly divided into treatment group and control group,with 20 cases in each group.Western medical treatment plans of both two groups were formulated according to the guidelines.The control group was given conventional western medicine.The treament group was given modified Chaihu Shugan powder on the basis of the control group.The abdominal pain symptoms,duration of aminotransferase descent and imaging findings before and after treatment were observed and compared.Results After treatment,the white blood cell count between the two groups had no statistically significant difference (t =0.28,P ＞ 0.05).The improvements of alanine aminotransferase,C-reactive protein and bilirubin in the treatment group were all better than those in the control group [(5.68 ± 2.26) ×109/Lvs.(5.50±1.98) ×109/L](t=-2.767,-2.96,-3.66,allP＜0.05).Conclusion Modified Chaihu Shugan powder in the adjuvant treatment of biliary acute pancreatitis has significant effect,and it is safe.
RESUMEN
Objective To observe the effect of Bupleurum Liver-Coursing Powder on the neuronal apoptosis and autophage in hippocampus of depression model rats, and to explore the mechanism of its anti-depression effect. Methods 60 male SD rats were randomly divided into control group,model group and drug intervention group (n=20).The depression model was produced by giving the rats chronic unpredicted mild stress.The rats in model group and control group received the same volume of normal saline,and the rats in drug intervention group received Bupleurum Liver-Coursing Powder solution on the basis of model.The depressional behavior was examined using sucrose preference test,tail-suspension test and Morris water maze.Flow cytometry was employed for the detection and quantification of the apoptotic cells in the hippcampus. The expressions of LC-3 and Beclin 1 were detected using Western blotting method. Results The pencertages of sucrose preference of the rats in model group and drug intervention group were significantly lower, while the tail-suspension immobility time and the excape latency time were higher than those in control group (P<0.05);the apoptotic rates of cells,the ratios of LC3-Ⅱ/LC3-Ⅰand the expression levels of Beclin-1 were higher than those in control group (P<0.05).Compared with model group,the percentage of sucrose preference of the rats in drug intervention group was increased (P<0.05),the tail-suspension immobility time and the excape latency time were decreased (P<0.05),and the apoptotic rate of cells,the ratio of LC3-Ⅱ/LC3-Ⅰand the expression level were also decreased (P<0.05).Conclusion Bupleurum Liver-Coursing Powder has significant anti-depression effect, which may be related to inhibiting the apoptosis and degrading the autophage of neuros.