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Objective To observe the therapeutic effect of clarithromycin combined with Cassia Twig-Poria Cocos capsule on patients with chronic pelvic inflammatory disease and its influence on high sensitivity C - reactive protein (hs-CRP). Methods 106 cases of patients with chronic pelvic inflammatory disease were selected to be divided into the observation group and control group with each group of 53 patients. The patients in control group were only given clarithromycin, on the base of control group, patients in observation group were given Cassia Twig-Poria Cocos. Both group were treated for three courses of 7-14 days. Then the therapeutic effect, adverse reactions, hs-CRP, erythrocyte sedimentation rate and hematocrit of patients were investigated. Results The total effective rate of patients in observation group was 90.57%, and the control group was 75.47%. The total effective rate of observation group was higher than control group with statistically significant difference (P<0.05). The hs-CRP, erythrocyte sedimentation rate and hematocrit of two groups both decreased after treatment (P<0.05) and these indexes of observation group was much less than control group (P<0.05). Besides, there was no difference of incidence of adverse reactions between two groups during the treatment. Conclusion Treatment of clarithromycin combined with Cassia Twig-Poria Cocos capsule on patients with chronic pelvic inflammatory disease not only can lessen inflammatory reaction, but also can improve the therapeutic effect effectively.
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Guizhi Fuling Capsule (GZFL), composed of Cassia Twig, Pachyma Cocos, Cortex Moutan, Radices Paeoniae Alba, and Peach Kernel, is a compound Chinese medicine preparation refined by modern technology. Modern pharmacology study shows that GZFL has pharmacological activities such as anti-inflammatory, analgesic, antitumor, smooth muscle relaxing, endocrine adjusting, and immunity enhancing activities. GZFL can be used in treatment of gynecological disease such as uterine fibroids, pelvic inflammatory disease, dysmenorrheal, and endometriosis in clinic, and it can be also used for the treatment of varicocele, hyperplasia of prostate, stroke, and carotid atherosclerosis. The phase II clinical trials of GZFL in treatment of primary dysmenorrhea in the United States of America have already finished. This paper makes a systematic review of the pharmacological activities and clinical applications of GZFL in recent years, in order to provide reference for its further development and utilization.
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Objective To explore the clinical effect of cassia twig tuckahoe capsule combined with mifepris-tone in the treatment of myoma of uterus,and to observe and analyze its influence on the quality of life,thus to provide basis for clinical treatment of uterine fibroids.Methods 138 patients with myoma of uterus were selected randomly. They were randomly divided into the control group and the observation group,69 cases in each group.The control group received mifepristone treatment,and the observation group received cassia twig tuckahoe capsule combined with mifepristone.The treatment effect of the two groups,tumor volume change were observed,follicle generate hormone (FSH),estradiol (E2 )and luteinizing hormone (LH)generated levels before and after treatment were detected,the quality of life and adverse reaction were assessed.Results The total effective rate of the observation group was 92.75% (64 /69),which was higher than the control group [82.61% (57 /69)],the difference was statistically significant (χ2 =10.16,P <0.05 ).The tumors volume of the observation group after treatment was (13.35 ± 1.17)cm3 ,which was lower than the control group after treatment (15.64 ±1.33)cm3 ,the difference was statistically significant (t =9.04,P <0.05).FSH and LH levels of the observation group after treatment were (30.55 ±6.14)U /L and (32.02 ±7.12)U /L,which were lower than the control group after treatment[(38.27 ±6.75)U /L and (36.91 ± 5.38)U /L],the differences were statistically significant (t =9.07,7.98,all P <0.05).E2 of the observation group after treatment was (53.41 ±5.13)pmol/L,which was higher than the control group after treatment[(47.82 ± 5.19)pmol/L],the difference was statistically significant (t =8.76,P <0.05).The period and menstrual volume of the observation group after treatment were (4.62 ±0.81)d and (52.36 ±6.21)mL,which were less than the control group after treatment[(6.71 ±0.86)d and (60.75 ±6.86)d],the differences were statistically significant (t =8.61,9.29,all P <0.05).The overall quality of life,physical function,emotional function and social function of the observation group after treatment were higher than the control group,the differences were statistically significant (t =10.26,9.69,10.13,10.27,all P <0.05).Conclusion Cassia twig tuckahoe capsule in combination with mifepris-tone in the treatment of myoma of uterus has better clinical curative effect,which can significantly improve sex hormone levels and menstrual status,and improve the quality of life.It has high security.
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This article was aimed to study the different clinical characteristics using drug pair of Cassia twig and white peony root with the contents ratio of 1:1 and 1:2. Based on the different clinical treatment of drug pair of Cas-sia twig and white peony root, different compositional ingredients in ratio of 1:1 and 1:2 were illuminated by HPLC/MS method. The drug pair of Cassia twig and white peony roots in ratio of 1:1 and 1:2 and single herbs were ex-tracted for HPLC/MS analysis. A protocol was followed, including acetonitrile - 0.1% acetic acid with gradient elution, positive mode, 350℃ capillary temperature and 300℃ vaporization temperature. The results showed that Procyanidol B2 and 2-Hydroxy cinnamal dehyde can be extracted from single Cassia twig, but 2-Hydroxy cinna-mal dehyde cannot be detected in drug pair. It showed the contents of Procyanidol B2 in 1:1 ratio was more than 1:2 ratio. Simultaneously, Palbinone, paeoniflorin sulfonate, 1,2,3,6-Tetra-O-galloyl-β-D-glucose, Paeoniflorin, Pae-oniflorin isomers, Benzoylpaeo-niflorin, and Benzoyl Paeoniflorin isomers can also be dissolved in white peony root. In addition, the contents of 1,2,3,6-Tetra-O-galloyl-β-D-glucose, Paeoniflorin, Benzoylpaeo-niflorin, and Benzoyl Paeoniflorin isomers in 1:1 were more than 1:2. The contents of Palbinone, paeoniflorin sulfonate and Paeoniflorin isomers in 1:2 were more than 1:1. It was concluded that Procyanidol B2, 1,2,3,6-Tetra-O-galloyl-β-D-glucose, Paeoniflorin, Benzoylpaeo-niflorin and Benzoyl Paeoniflorin isomers in 1:1 were more than 1:2. The contents of Pal-binone, Paeoniflorin sulfonate and Paeoniflorin isomers in 1:2 were more than 1:1. It provided a scientific basis for traditional Chinese medicine treatment using rational drug pair.
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It sums up characteristics and range of Bupleurum preparation in "Febrile Disease";centering on main line of Little Bupleurum Decoction and Bupleurum Cassia Twig Decoction,combining with Pro.Chen Baotian's experience and modern documentation,it expounds systemically from 3 points of indications,joint application and modern research review.