RESUMEN
The effect of lipid lowering agents of plant origin garlic oil and guggulipid on the levels of catecholamine and dopamine ß-hydroxylase activity of normal and cholesterol fed rabbit tissues has been studied. The catecholamine levels and enzyme activity were found to be decreased in cholesterol (500 mg/kg body wt) fed animals. The feeding of garlic oil (5 mg/kg body wt) and guggulipid (100 mg/kg body wt) an exudate of Commiphora mukul, to normal rabbits caused significant increase in the dopamine-ß-hydroxylase activity and catecholamine levels, while the feed helped the hypercholesterolemic rabbits to recover the decrease in catecholamine biosynthesis.
RESUMEN
The effect of propranolol on the levels of catecholamine in different parts of rat brain has been studied. The catecholamine contents of different regions were lowered by the drug. Dopamine β-hydroxylase activity was also reduced, both in vivo and in vitro. Propranolol is taken up by the brain tissue and the uptake is timedependent. These results suggests that reduction in brain catecholamine levels and dopamine β-hydroxylase activity may be one of the possible ways through which the drug manifests its clinical effects.