Caracterización de pacientes con síndrome cerebral perdedor de sal en afecciones en neurológicas graves / Characterization of patients presenting with salt wasting cerebral syndrome in severe neurologic affections

Introducción: La hiponatremia es un problema común y grave en la medicina clínica. Objetivo: caracterizar a los pacientes con síndrome cerebral perdedor de sal en la evolución y pronóstico de las afecciones neurológicas graves y su relación con la evolución neurológica. Métodos: se realizó un estudio observacional, analítico, longitudinal y prospectivo con un universo de 114 pacientes. Resultados: se presentó el síndrome cerebral perdedor de sal en 23 de los 114 casos para un 20,2 por ciento de pacientes afectados. Se encontró mayor incidencia en la hemorragia subaracnoidea (55,6 por ciento), tumores (36,4 por ciento) y la hemorragia intraparenquimatosa (17,6 por ciento). De los 56 pacientes con una evolución neurológica desfavorable, 16 presentaban el síndrome (28,5 por ciento) y hubo mayor porcentaje de fallecidos entre los que lo tenían (23,1 por ciento versus 17,7 por ciento que no lo tenían). La mortalidad no mostró diferencias significativas en cuanto al número total de fallecidos. Conclusiones: el síndrome cerebral perdedor de sal presenta una alta incidencia en pacientes con afecciones neurológicas agudas, asociándose más frecuentemente la hemorragia subaracnoidea, los tumores intracraneales y la enfermedad cerebrovascular isquémica. Tiene relación con la evolución neurológica y es más probable padecerlo cuando esta es desfavorable

Introduction: hyponatremia is common and severe problem in clinical medicine. Objective: to characterize the patients presenting with salt wasting cerebral syndrome in the evolution and prognosis of severe neurological lesions and its relation to the neurologic course. Methods: a prospective, longitudinal, analytical and observational study was conducted in 114 patients. Results: the salt losing cerebral syndrome was present in 23 of the 114 cases for a 20.2 percent of patients involved. There was a great incidence in subarachnoid hemorrhage (55.6 percent), tumors (36.4 percent) and the intra-parenchymatous hemorrhage (17.6 percent). From the 56 patients with a unfavourable, 16 had the above mentioned syndrome (28.5 percent) and there was a greater percentage of deceased among those with it (23.1 percent vs. 17.7 percent without it). Mortality not showed significant differences as regards the total figure of deceased. Conclusions: the salt wasting cerebral syndrome has a high incidence in patients with acute neurological affections, with a more frequent association with subarachnoid hemorrhage, the intracranial tumors and the ischemic cerebrovascular disease. It has relation to the neurologic evolution and it is more probable its suffering when it is unfavourable

Oculo-Cerebral Syndrome after Spontaneous Subarachnoid Hemorrhage

OBJECTIVE: Oculo-cerebral syndrome is an intraocular hemorrhage and related ocular symptoms caused by sudden increase in intracranial pressure. The authors investigate the clinical significance of oculo-cerebral syndrome after spontaneous subarachnoid hemorrhage and analyze the characteristics of aneurysms which caused intraocular hemorrhage in order to help the treatment of intracranial aneurysm patients. METHODS: From January 2000 to May 2001, 103 patients were admitted to our hospital and diagnosed as spontaneous subarachnoid hemorrhage. We divided the patients into two groups:81 patients without intraocular hemorrhage(non-IOH) and 22 patients with intraocular hemorrhage(IOH). The authors prospectively analyzed the prognostic factors of spontaneous subarachnoid hemorrhage by chi-square test. RESULTS: The initial neurologic state was poor in the IOH group(p<0.001). The Fisher's grade was higher than non-IOH group(p<0.001), and intracranial hemorrhage was great in the IOH group(p<0.001). The prognosis was poor in the IOH group at discharge(p<0.001). The most common rupture site in the IOH group was the anterior communicating artery(p<0.001). Frontal intracerebral hematoma was specific to intraocular hemorrhage(p<0.05). There was a positive correlation between intraocular hemorrhage and rebleeding(p<0.001). CONCLUSION: The authors suggest that oculo-cerebral syndrome is clinically significant with a poor prognostic factor in patients with spontaneous subarachnoid hemorrhage.

A Case of Cerebral Syndrome Associated with High-Dose Cytosine Arabinoside Chemotherapy / 대한혈액학회지

Cytosine arabinoside (Ara-C) is a highly active agent in the treatment of acute leukemia and malignant lymphoma. The use of high-dose Ara-C therapy has been advanced as a possible means of overcoming resistance. High dose Ara-C regimens are occasionally associated with cerebellar and cerebral toxicities while toxicities in conventional dose regimens are mainly restricted to the bone marrow and gastrointestinal tract. A 21-year-old male patient with acute lymphoblastic leukemia in second relapse developed cerebral syndrome 10 days after high-dose Ara-C chemotherapy. We present a case of acute cerebral toxicity after high dose Ara-C chemotherapy with relevant literature review.