RESUMEN
Objetivo: Relatar um caso de carcinoma do plexo coroide e advertir a comunidade pediátrica sobre a importância de considerar os tumores do sistema nervoso central como diagnóstico diferencial de vômitos persistentes em crianças. Descrição: Apresentamos um caso de carcinoma do plexo coroide em criança de 1 ano e 11 meses de idade, internada com história de vômitos persistentes há um ano e irritabilidade. Discutimos brevemente os diagnósticos diferenciais e realizamos a revisão da literatura. Comentários: O carcinoma de plexo coroide é um tumor raro do sistema nervoso central, derivado do epitélio de revestimento dos plexos coroides, que acomete principalmente pacientes abaixo dos três anos. A identificação e o tratamento precoces podem proporcionar melhor prognóstico.
Asunto(s)
Humanos , Masculino , Femenino , Recién Nacido , Carcinoma , Niño , Plexo CoroideoRESUMEN
Aims: To describe a case of choroid plexus carcinoma which initial signs and symptoms were related to the upper respiratory tract, contrary to the classic symptomatology of this disease reported in the literature. Case description: A two years and eight months old boy was admitted due to acute respiratory failure. He was treated with antibiotics for suspected croup without success. After two weeks he presented neurological manifestations that led to investigation and diagnosis of choroid plexus carcinoma. Resection was contraindicated due to extension of the tumor and involvement of vital areas.Conclusions: The rapid evolution of choroid plexus carcinoma in this case points to the need for early suspicion of central nervous system disorders. This case may alert pediatricians to the need to consider the presence of a brain tumor causinginjury to the vagus nerve in cases of respiratory distress resistant to treatment.
Objetivos: Descrever um caso de carcinoma do plexo coroide no qual os sinais e sintomas iniciais foram relacionadas ao trato respiratório superior, ao contrário da sintomatologia clássica da doença reportada na literatura.Descrição do caso: Um menino de dois anos e oito meses de idade foi internado por insuficiência respiratória aguda.O paciente foi tratado com antibióticos para suspeita de crupe, sem sucesso, e após oito dias mostrou sintomatologia neurológica, que levou a uma investigação e ao diagnóstico de carcinoma do plexo coroide. A ressecção foi contra-indicadadevido à extensão do tumor e envolvimento de áreas vitais.Conclusões: A evolução rápida do carcinoma do plexo coroide neste caso mostra a necessidade da suspeita precoce de distúrbios do sistema nervoso central. Este caso pode alertar os pediatras para a necessidade de considerar a presença de um tumor cerebral levando a lesão do nervo vago em casos de dificuldade respiratória resistente ao tratamento.
Asunto(s)
Humanos , Masculino , Femenino , Niño , Manifestaciones Neuroconductuales , Neoplasias Encefálicas , Neoplasias del Plexo Coroideo , Nervio VagoRESUMEN
Choroid plexus cysts (CPCs) are the most commom neuroepithelial cysts, occuring in more than 50% of some autopsy series. They are typically small and asymptomatic and are discovered incidentally in older patients, usually in the trigone of the lateral ventricle. Symptomatic CPCs (usually exceptionally large, 2-8 cm) are rare. The authors report a case of large symptomatic choroid plexus cyst, located in the trigone of the right lateral ventricle in a 26-yr-old man who presented with headache and vomiting. The patient underwent endoscopic removal through a burr hole placed 3 cm from the midline and just behind the hair line. The histological examination of the cyst wall was consistent with choroid epithelium. Despite of postoperative intraventricular hemorrhage and catheter infection, he discharged home without neurologic deficits. The endoscopic fenestration rather than excision should be considered as the first surgical procedure because the goal of treatment is shrinkage of the cyst until normal cerebrospinal fluid flow is restored.
Asunto(s)
Adulto , Humanos , Masculino , Encefalopatías/diagnóstico , Plexo Coroideo , Quistes/diagnóstico , EndoscopíaRESUMEN
Choroid plexus carcinoma (CPC), a frankly malignant epithelial neoplasm derived from choroid plexus epithelium, is a rare tumor with a predilection for infants and children. It may be difficult to histologically differentiate it from choroid plexus papilloma, anaplastic ependymoma, medulloblastoma, germ cell tumors, and metastatic carcinoma. We examined two cases of CPC. One is a 12-month-old boy, and the other is a 13-month-old boy. Both patients present lateral ventricular masses with extensive hydrocephalus. Histologically, both tumors show papillary growth in most area, and focal solid growth. The tumor cells show marked nuclear pleomorphism and frequent mitoses on squash and hematoxylin-eosin slides. Immunohistochemically, both tumors are positive for cytokeratin, vimentin, and S-100 protein; but they are negative for glial fibrillary acidic protein, -fetoprotein, and placental alkaline phosphatase. Both tumors show diffuse and strong positivity for p53. The MIB-1 labelling index is 23.6% and 15.82%, respectively. We report two cases of typical CPC, and we briefly discuss differential diagnosis with review of literatures.