RESUMEN
Choto-san was administered to 6-week-old spontaneously hypertensive rats (SHR) at the usual dose used for humans and at a 10-times higher dose, and its effects on blood pressure and the autonomic nervous system were examined. Significant blood pressure elevation was noted in the SHRs administered with the 10-fold dose, but no such changes were observed in the SHRs that were administered the usual human dose. Since the urinary levels of adrenaline and noradrenaline and the granulocyte count significantly increased in the 10-fold dose group, the elevation in blood pressure in this group appears to be attributable to stimulation of the sympathetic nervous system. Accelerated sympathetic nervous activity is noted in SHRs during the growing stage, and the excessively high dose of Choto-san probably further stimulated the sympathetic nervous activity.
RESUMEN
We report three elderly patients in the extended care unit who were successfully treated orally with Chotosan. Case 1 was an 84-year-old male who was hospitalized for lowered volition after aspiration pneumonia in 1999. He received nutrition through a stomach fistula. Administration of Choto-san increased his volition, and he resumed eating normally after practicing swallowing. Case 2 was a 99-year-old woman who was hospitalized for lower volition after a thighbone fracture in 2000. She also could not eat orally, and received nutrition via nasal-tube feeding. After the administration of Choto-san, she developed a will to eat, and she could again have meals orally. Case 3 was an 84-year-old woman who was hospitalized for lowered volition after aspiration pneumonia in 1999. She had pressure ulcers and was often feverish, so she was fed by nasal tube. She was treated with Choto-san, and was able to eat normally again after practicing swallowing. Her pressure ulcers were cured. This suggests that the administration of Choto-san may be successfully utilized as part of a strategy for overcoming swallowing trouble in the elderly.
RESUMEN
Although the treatment of Parkinson's disease is well established, side effects and weaning effects in the long term are a problem. In this context, it is reasonable to establish an alternative medicine for Parkinson's disease. Hange-byakujutsu-tenma-to in traditional Japanese medicine (Kampo) is similar to Teishingan, a formula for Parkinson's disease in traditional Chinese medicine, in that both formulas contain tenma and qi-supplying agents. We therefore administered Hange-byakujutsu-tenma-to (TJ-37, Tsumura, Tokyo) to a 77-year-old woman with Parkinson's disease. After taking Hange-byakujutsu-tenma-to, her symptoms of rigidity of the upper limbs, frozen gait, propulsion and retropulsion improved. These results suggest that Hange-byakujutsu-tenma-to is useful for treating Parkinson's disease.
RESUMEN
It has been reported that Choto-san (diao teng san) is effective for the treatment of patients suffering from hypertension. Narrowing of the retinal arterioles is one of the important findings in hypertension.<br>The authors examined the pharmacological effects of Choto-san on the blood pressure and narrowing of the retinal arterioles in spontaneously hypertensive rats (SHR) and strokeprone SHR (SHRSP).<br>SHR and SHRSP rats (nine treatment cases and five control cases) were used. 200mg/kg/day of Choto-san was administered orally to the SHR and SHRSP for 12 weeks. After the 12 weeks of administration, the blood pressure was measured by the tailcuff method. Narrowing of the retinal arterioles was measured by the percentage ratio of the artery to vein caliber.<br>After three months of administration of Choto-san, the blood pressure of the SHR and SHRSP was shown to be significantly lower than that of the control. The percentage ratio of the artery to vein caliber in the treatment group was shown to be significantly higher than that of the control group SHR and SHRSP.<br>These findings suggest that Choto-san may lower the blood pressure and inhibit narrowing of the retinal arterioles in SHR and SHRSP.
RESUMEN
Choto-san was given to a patient with narcolepsy. Four days later, symptoms such as paroxysmal sleep, impulsive cataplexy and hypnagogic hallucinations had disappeared.<br>In the Kampo treatment of narcolepsy, although there have been reports of remarkable reduction in symptoms upon administration of Kakkon-to 1) 3) and Hochuekki-to-ka-miho 4), this is the first report of the symptoms disappearing so rapidly upon administration of Choto-san.