Experiencia en enfermería, ensayo clínico y atención a pacientes con cáncer de pulmón / Experience in nursing, clinical assay and care of patients with lung cancer

INTRODUCCIÓN: los ensayos clínicos con nuevas sustancias, como anticuerpos y vacunas han tenido un incremento debido a la necesidad de encontrar nuevas terapéuticas para el tratamiento del cáncer. En la aplicación del tratamiento el éxito depende del buen desempeño profesional, el nivel de preparación y capacitación que tenga el personal de enfermería, como parte del equipo de investigación al ejecutar un rol importante. OBJETIVO: evaluar la experiencia del personal de enfermería en este ensayo relacionado con la atención a pacientes con cáncer de pulmón. MÉTODOS: se realizó un estudio descriptivo con una revisión bibliográfica sobre el actuar, y la experiencia de enfermería en el ensayo clínico. Se evaluó la seguridad de CIMAvax®- EGF en pacientes avanzados con tumores del pulmón, de células no pequeñas y tratados en la asistencia primaria de salud. Para ello se realizó un análisis documental de la buena práctica clínica, y los protocolos de estudios sobre el tema. RESULTADOS: fueron incluidos 11 pacientes. El promedio de diagnóstico y tratamiento de pacientes, con cáncer de pulmón estuvo en 23 y 14 meses al respecto. CONCLUSIONES: enfermero (a) en su desempeño debe tener dominio del protocolo en su totalidad sobre el producto, propiedades farmacéuticas y dosis a administrar. Además, identificar las reacciones adversas que pueden presentarse y las medidas a tomar para de esta forma lograr evaluar la efectividad del nuevo producto en investigación y mitigar cualquier riesgo que influya en la calidad y excelencia de nuestros servicios de salud.

INTRODUCTION: an increase in clinical assays of new substances, such as antibodies and vaccines, has taken place in response to the need to find new cancer therapies. Success in the application of treatment depends on the good professional performance, background and training of nursing personnel, for they play an important role as research team members. OBJECTIVE: evaluate the experience of nursing personnel in an assay about the care of patients with lung cancer. METHODS: a descriptive study was conducted based on a bibliographic review of the role and experience of nurses in the clinical assay performed. The safety of CIMAvax®- EGF was evaluated in patients with advanced non-small-cell lung tumors treated at primary health care services. For this purpose a document analysis was performed about good clinical practice and study protocols about the subject. RESULTS: eleven patients were included. Average diagnosis and treatment of patients with lung cancer was 23 and 14 months, respectively. CONCLUSIONS: nurses should be thoroughly aware of the entire protocol, particularly the product, its pharmaceutical properties and the dose to administer. They should also be able to identify the potential adverse reactions and the measures to take to assess the effectiveness of the new product under research, as well as mitigate any risk affecting the quality and excellence of our health services.

Estudo randomizado, duplamente mascarado, placebo controlado do uso do misoprostol versus placebo para histeroscopia diagnostica em mulheres na pos-menopausa / A randomized, double-masked, placebo-controlled study of the use of misoprostol versus placebo for diagnostic hysteroscopy in postmenopausal women

A histeroscopia é um dos procedimentos mais realizados em ginecologia. Muitos ensaios controlados sugerem vantagens no uso prévio de misoprostol para diminuir a resistência da cérvix uterina; entretanto este tipo de estudo ainda é escasso quando se compara o uso do misoprostol prévio à histeroscopia diagnóstica em mulheres na pós-menopausa. avaliar os efeitos intra e pós-operatórios em mulheres na pós-menopausa, submetidas à histeroscopia diagnóstica, sem anestesia, com uso prévio de misoprostol para amadurecimento do colo uterino. Sujeitos e métodos: foi realizado um estudo tipo ensaio clínico, duplamente mascarado, randomizado, em pós-menopausadas que se submeteram à histeroscopia diagnóstica sem anestesia no IMIP e no hospital Barão de Lucena, em Recife, Pernambuco. Foram incluídas 120 pacientes alocadas aleatoriamente em dois grupos, sendo 60 com uso de 200µg de misoprostol via vaginal e 60 com uso de 200µg de placebo. Foram estudadas as seguintes variáveis: tempo do procedimento, freqüência e intensidade da dor durante o exame, necessidade de dilatação cervical adicional, efeitos colaterais (sangramento genital, náuseas, vômitos, diarréia, hipertermia) e complicações (perfuração uterina, falso pertuito, laceração cervical, infecções, dor no pós-operatório imediato). Para análise estatística, utilizaram-se os testes de qui-quadrado de associação, testes exato de Fisher e Mann-Whitney para comparação dos grupos, considerando-se significativo um erro alfa menor que 5 por cento. Resultados: os grupos foram semelhantes em relação...

Hysteroscopy is one of the most useful procedure to study uterine cavity and widely used in gynecologic clinic. Although many controlled clinical trials have shown advantages in the use of misoprostol in realeasing cérvix uterine resistanse, there are few evidence regarding its use before office hysteroscopy in postmenopausal women. Objective: to compare the trans and postoperative results of postmenopausal women underwent office hysteroscopy without anesthesia that used misoprostol or placebo previouslly to the procedure to mature the uterine cérvix in two teaching hospitals in Recife. Patients and methods: a randomized, double masked, clinical trial was conducted enrolling 120 postmenopausal women who had been submitted to office hysteroscopy without anesthesia at IMIP and Barão de Lucena teaching hospital. Among those patients 60 were randomized allocated in the study group using 200µg of vaginal misoprostol and 60 took part in the placebo group using 200µg of a vaginal placebo.The following variable were studied: duration of the procedure, frequency and intensity of pain during the exame, necessity of additional dilatation, side effect as (genital bleeding, nauseas, vomits, diarrhea, and hyperthermia) and complications (uterine perforation, false way, cervical laceration, infections and pain in the imediate postoperatory period). For analysis statistics we used the tests of association qui-square, accurate test of Fisher and Mann-Whitney for comparison of the groups, considering itself significant with lesser alpha error that 5 por cento. Results: We found no significant statistic difference between the...