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Objective@#To compare the therapeutic effect of different drug in the treatment of schizophrenia in acute stage.@*Methods@#From November 2014 to June 2017, 105 patients with acute schizophrenia admitted in Department of Psychiatry of Taiyuan Psychiatric Hospital and Department of Psychiatry of Jiuzhou Dermatological Hospital of Taiyuan were selected in the study.Seventy-five patients were from the Department of Psychiatry, Taiyuan Psychiatric Hospital.Thirty patients were from the Department of Psychiatry, Jiuzhou Dermatology Hospital.The patients were divided into three groups by random number method, with 35 cases in each group.A group was given amisulpride.B group was given olanzapine.C group was given ziprasidone.The PANSS score (positive symptoms, negative symptoms, mental pathological score), curative effect (cured, significantly improved, invalid), adverse events (EPS, akathisia, nausea, rapid heart beat, blurred vision, orthostatic dizziness, weight gain, total adverse events) in the three groups were observed.@*Results@#After treatment for 2 weeks, the positive symptoms.negative symptoms, mental pathological score in the three groups were significantly decreased (all P<0.05). The positive symptoms.negative symptoms, mental pathological score at corresponding period had no statistically significant differences among the three groups (all P>0.05). There was no statistically significant difference in therapeutic effect among the three groups (P>0.05). The occurrence of EPS of C group was significantly lower than that of B group [14.29%(5/35) vs.40.00%(14/35), χ2=5.851, P<0.05]. The incidence rate of adverse events of C group was significantly lower than that of A group and B group (χ2=5.833, 4.690, all P<0.05). However, there was no statistically significant difference in the occurrence of adverse events between A group and B group(P>0.05).@*Conclusion@#Amisulpride, olanzapine and ziprasidone in the treatment of acute phase of schizophrenia has good early reaction control and late curative effect.The adverse events of ziprasidone is significantly less than the other two drugs.But patients adopt which kind of drugs also need to formulate specific solutions according to individual circumstance.
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Objective@#To explore the effects of improved pterion approach on neurological function and prognosis of patients with craniocerebral trauma.@*Methods@#From July 2014 to July 2016, 100 patients with craniocerebral trauma admitted to Hangzhou Dajiang East Hospital were selected in this study, and they were divided into two groups according to different surgical methods, with 50 cases in each group.The control group was given traditional surgical approach, and the observation group was given improved pterion approach surgery.The neurological function, safety and prognosis of the two groups were observed.@*Results@#The NDS scores and GCS scores had no statistically significant differences between the two groups before treatment(t=1.03, 0.98, all P>0.05). After treatment, the NDS scores of the two groups were significantly reduced(t=5.62, 7.23, all P<0.05), the GCS scores of the two groups were significantly improved(t=3.46, 4.75, all P<0.05). The NDS score of the observation group was (13.72±5.42)points, which was significantly lower than that of the control group[(20.72±6.51)points](t=4.32, P<0.05). The GCS score of the observation group was (11.25±2.63)points, which was significantly higher than that of the control group[(8.42±1.35)points](t=3.27, P<0.05). The incidence rate of complications of the control group was significantly higher than that of the observation group[48%(24/50) vs.18%(9/50), χ2=7.36, P<0.05]. The mortality rate of the control group was significantly higher than that of the observation group[32%(15/50) vs.16%(8/50), χ2=3.17, P<0.05], and the recovery rate of the control group was significantly lower than that of the observation group[14%(7/50) vs.28%(14/50), χ2=6.35, P<0.05]. Before treatment, there were no statistically significant differences in the Spitzer index between the two groups(t=1.01, 0.98, 0.92, 0.98, 0.87, all P<0.05). After treatment, the Spitzer index of the two groups were significantly higher than those before treatment(t=2.72, 3.64, 2.83, 3.45, 3.52, 3.67, 3.84, 4.61, 4.53, 5.27, all P<0.05), which of the observation group were significantly higher than those of the control group(t=2.56, 2.73, 4.26, 4.43, 3.95, all P<0.05).@*Conclusion@#The improved pterion approach in the treatment of patients with craniocerebral trauma has better neural functional recovery than traditional surgery, and it has lower mortality rate and complication rate, better security, and can encourage patients to improve the quality of life, and it has better prognosis.
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Objective To compare the therapeutic effect of different drug in the treatment of schizophrenia in acute stage.Methods From November 2014 to June 2017,105 patients with acute schizophrenia admitted in Department of Psychiatry of Taiyuan Psychiatric Hospital and Department of Psychiatry of Jiuzhou Dermatological Hospital of Taiyuan were selected in the study.Seventy-five patients were from the Department of Psychiatry,Taiyuan Psychiatric Hospital.Thirty patients were from the Department of Psychiatry,Jiuzhou Dermatology Hospital.The patients were divided into three groups by random number method,with 35 cases in each group.A group was given amisulpride.B group was given olanzapine.C group was given ziprasidone.The PANSS score (positive symptoms,negative symptoms,mental pathological score),curative effect (cured,significantly improved,invalid),adverse events (EPS,akathisia,nausea,rapid heart beat,blurred vision,orthostatic dizziness,weight gain,total adverse events) in the three groups were observed.Results After treatment for 2 weeks,the positive symptoms,negative symptoms,mental pathological score in the three groups were significantly decreased (all P ＜ 0.05).The positive symptoms,negative symptoms,mental pathological score at corresponding period had no statistically significant differences among the three groups (all P ＞ 0.05).There was no statistically significant difference in therapeutic effect among the three groups (P ＞0.05).The occurrence of EPS of C group was significantly lower than that of B group [14.29％ (5/35) vs.40.00％ (14/35),x2 =5.851,P ＜ 0.05].The incidence rate of adverse events of C group was significantly lower than that of A group and B group (x2 =5.833,4.690,all P ＜ 0.05).However,there was no statistically significant difference in the occurrence of adverse events between A group and B group(P ＞ 0.05).Conclusion Amisulpride,olanzapine and ziprasidone in the treatment of acute phase of schizophrenia has good early reaction control and late curative effect.The adverse events of ziprasidone is significantly less than the other two drugs.But patients adopt which kind of drugs also need to formulate specific solutions according to individual circumstance.
RESUMEN
Objective To explore the effects of improved pterion approach on neurological function and prognosis of patients with craniocerebral trauma.Methods From July 2014 to July 2016,100 patients with craniocerebral trauma admitted to Hangzhou Dajiang East Hospital were selected in this study,and they were divided into two groups according to different surgical methods,with 50 cases in each group.The control group was given traditional surgical approach,and the observation group was given improved pterion approach surgery.The neurological function,safety and prognosis of the two groups were observed.Results The NDS scores and GCS scores had no statistically significant differences between the two groups before treatment (t =1.03,0.98,all P ＞ 0.05).After treatment,the NDS scores of the two groups were significantly reduced (t =5.62,7.23,all P ＜ 0.05),the GCS scores of the two groups were significantly improved(t =3.46,4.75,all P ＜ 0.05).The NDS score of the observation group was (13.72 ± 5.42) points,which was significantly lower than that of the control group [(20.72 ± 6.51) points] (t =4.32,P ＜ 0.05).The GCS score of the observation group was (l 1.25 ± 2.63) points,which was significantly higher than that of the control group [(8.42 ± 1.35) points] (t =3.27,P ＜ 0.05).The incidence rate of complications of the control group was significantly higher than that of the observation group [48％ (24/50) vs.18％ (9/50),x2 =7.36,P ＜ 0.05].The mortality rate of the control group was significantly higher than that of the observation group [32％(15/50) vs.16％ (8/50),x2 =3.17,P ＜ 0.05],and the recovery rate of the control group was significantly lower than that of the observation group [14％ (7/50) vs.28％ (14/50),x2 =6.35,P ＜ 0.05].Before treatment,there were no statistically significant differences in the Spitzer index between the two groups(t =1.01,0.98,0.92,0.98,0.87,all P ＜ 0.05).After treatment,the Spitzer index of the two groups were significantly higher than those before treatment (t =2.72,3.64,2.83,3.45,3.52,3.67,3.84,4.61,4.53,5.27,all P ＜ 0.05),which of the observation group were significantly higher than those of the control group (t =2.56,2.73,4.26,4.43,3.95,all P ＜ 0.05).Conclusion The improved pterion approach in the treatment of patients with craniocerebral trauma has better neural functional recovery than traditional surgery,and it has lower mortality rate and complication rate,better security,and can encourage patients to improve the quality of life,and it has better prognosis.