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Curcuma kwangsiensis root tuber is a widely used genuine medicinal material in Guangxi, with the main active components of terpenoids and curcumins. It has the effects of promoting blood circulation to relieve pain, moving Qi to relieve depression, clearing heart and cooling blood, promoting gallbladder function and anti-icterus. Modern research has proved its functions in liver protection, anti-tumor, anti-oxidation, blood lipid reduction and immunosuppression. Considering the research progress of C. kwangsiensis root tubers and the core concept of quality marker(Q-marker), we predicted the Q-markers of C. kwangsiensis root tubers from plant phylogeny, chemical component specificity, traditional pharmacodynamic properties, new pharmacodynamic uses, chemical component measurability, processing methods, compatibility, and components migrating to blood. Curcumin, curcumol, curcumadiol, curcumenol, curdione, germacrone, and β-elemene may be the possible Q-markers. Based on the predicted Q-markers, the mechanisms of the liver-protecting and anti-tumor activities of C. kwangsiensis root tubers were analyzed. AKT1, IL6, EGFR, and STAT3 were identified as the key targets, and neuroactive ligand-receptor interaction signaling pathway, nitrogen metabolism pathway, cancer pathway, and hepatitis B pathway were the major involved pathways. This review provides a basis for the quality evaluation and product development of C. kwangsiensis root tubers and gives insights into the research on Chinese medicinal materials.
Asunto(s)
Humanos , China , Curcuma/química , Hígado , Neoplasias , Terpenos/farmacologíaRESUMEN
OBJECTIVE：To study the analgesic effects of 4 sources of Curcumae Radix decoction pieces （Curcuma wenyujin ， C. kwangsiensis ，C. phaeocaulis and C. longa ），and compare the contents of curcumenol in their water extracts. METHODS ： Using aspirin as positive control ，acetic acid writhing method was used to investigate the effects of 4 sources of Curcumae Radix decoction pieces water extract on writhing latency and times of writhing in mice. The moisture contents of 4 sources of Curcumae Radix decoction pieces （10 batches of each source ，the same below ）were determined according to the drying method in 2015 edition of Chinese Pharmacopoeia （part Ⅳ）. The yield of water extract in 4 sources of Curcumae Radix decoction pieces were investigated by hot dipping method ，the contents of curcumenol in water extract of 4 sources of Curcumae Radix decoction pieces were determined by HPLC ，and comparison was conducted. RESULTS ：Compared with model group ，aspirin and water extracts of 4 sources of Curcumae Radix decoction pieces could significantly prolong the writhing latency of model mice ，and the water extracts of C. wenyujin and C. phaeocaulis could significantly reduce the writhing times of model mice （P＜0.05 or P＜0.01）. For C. wenyujin ，C. kwangsiensis ，C. phaeocaulis and C. longa ，the contents of moisture were 7.39％-8.80％，7.88％-9.88％，7.66％- 10.5468/ogs.2019.62.6.382 9.86％ and 7.68％-10.20％；the average yield of water extract were 46.30％，60.40％，38.65％，42.99％；the average contents of curcumenol in water extract were 0.271，0.066，0.310，0.058 mg/g. Except for a few batches ，the higher the yield of water extract，the higher the content of curcuminol in the same source of Curcumae Radix decoction pieces. CONCLUSIONS ：Four sources of Curcumae Radix decoction pieces have analgesic effect. The contents of curcumenol in C. wenyujin and C. phaeocaulis were similar ，and the contents of curcumenol in C. kwangsiensis and C. longa about 1/5 of that in C. phaeocaulis and C. wenyujin .
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Objective To study the physical-chemical parameters of curcumenol so as to design its optimal preparations. Methods An HPLC method was established to determine the content of curcumenol. Based on the method,the equilibrium solubility, oil/water partition coefficient and stability of curcumenol were investigated. Results The equilibrium solubility in the pure water was 1.93 mg/ml(25℃)and 2.6 mg/ml(37℃),respectively. The oil/water partition coefficient was in the range of 2.2-3.0. Curcumenol solution was unstable at high temperature under light conditions,while pH value showed little effect. Conclusion The analytical method is accurate and reliable. The solubility of curcumenol can be described as strong lipotropic and slightly soluble in water. Nano-formulation and solubilization technologies could improve its bioavailability significantly. Curcumenol should be stored and operated in a dark and cool place.
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Objective To study the physical- chemical parameters of curcumenol so as to design its optimal preparations. Methods An HPLC method was established to determine the content of curcumenol. Based on the method, the equilibrium solubility, oil/water partition coefficient and stability of curcumenol were investigated. Results The equilibrium solubility in the pure water was 1.93 mg/ml (25 °C) and 2.6 mg/ml (37°), respectively. The oil/water partition coefficient was in the range of 2.2-3.0. Curcumenol solution was unstable at high temperature under light conditions, while pH value showed little effect. Conclusion The analytical method is accurate and reliable. The solubility of curcumenol can be described as strong lipotropic and slightly soluble in water. Nanoformulation and solubilization technologies could improve its bioavailability significantly. Curcumenol should be stored and operated in a dark and cool place.
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Objective: To investigate the chemical constituents in the roots and rhizomes of Curacuma aromtica. Methods: The chemical constituents were separated and purified by silica gel, Sephadex LH-20 column chromatography, preparative HPLC, and so on. Their structures were determined by physicochemical constants and spectral analyses. Results: Seventeen compounds were obtained and identified as curdione (1), β-sitosterol (2), stigmasterol (3), triaconatanoic acid (4), gweicurculactone (5), curcumenol (6), procurcumenol (7), eudesmane-3, 6-dione (8), lupeol (9), curcumin (10), demethoxycurcumin (11), aerugidiol (12), zedoarondiol (13), voleneol (14), uracil (15), curcumol (16), and curcumenone (17). Conclusion: Compounds 4, 5, 8, 9, 14, and 15 are isolated from the plant for the first time.
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OBJECTIVE: To investigate the effect and mechanism of Curcumenol against leukemia and to provide theoretical basis for the development and utilization of Curcumenol.METHODS:Curcumenol liposomes were prepared by mechanical dispersion method and ultrasonic method.MTT method was used to detect the inhibitory effects of Curcumenol and other drug on L1210 proliferation in mice with Lymphocytic leukemia.The apoptosis of L1210 cells induced by Curcumenol was observed under confocal microscope by trypan blue exclusion test and Hoechst 33258/PI double staining.RESULTS: Curcumenol significantly inhibited the proliferation of L1210 cells and induced apoptosis of L1210 cells.CONCLUSION: The anti-tumor effect of Curcumenol is possibly achieved by inducing the apoptosis of L1210 cells.