Lesión cutánea por radiación en angioplastía coronaria compleja / Cutaneous radiation injury after failed percutaneous coronary angioplasty

Resumen: Las lesiones cutáneas por radiación (LCR) son una complicación infrecuente, con un estimado de 3.600 casos de lesiones mayores reportados en la actualidad. Presentamos un caso de lesión eritematosa mayor por radiación posterior a angioplastía coronaria fallida y en segundo tiempo angioplastía coronaria con rotablación.

Abstract: Cutaneous radiation injuries are an infrequent complication, with an estimated 3.600 cases of major injuries reported up to now. We present a case of a major erythematous lesion induced by radiation after failed coronary angioplasty and consecutive coronary rotablation.

The study on serum level and clinical significance of anti-ribosomal protein P0 antibody in DLE and SLE patients / 实用医学杂志

Objectives To study the serum level and the clinical significance of anti-ribosomal protein P0 antibody in discoid lupus erythematosus(DLE) and systemic lupus erythematosus(SLE) patients. Methods Serum anti-RPLP0 IgG antibody of 18 DLE patients and 23 SLE patients were tested by Enzyme-Linked Immunosorbent Assay (ELISA). Direct immunofluoreseence (DIF) was used to examined the immunoreaetants from skin lesion. Serum antibody and complement C3 were detected by conventional methods. Results Anti-ribosomal P0 antibody was higher in SLE patients (1.23 ± 0.62. mean ± SD) than in patients with DLE (0.53 ± 0.18, P<0.001) and healthy controls (0.72 ± 0.16, P<0.001), but was no difference in the later two groups (P=0.5). Among SLE patients , anti-ribosomal P0 protein antibody were much higher in patients with arthritis , nephritis and specific skin lesion than in those without these disorders (P<0.05). Anti-ribosomal P0 antibody was not associated with SLEDAI and CLASI(P=0.012). Conclusions There is no difference of serum anti-ribosomal P0 antibodies between healthy controls and DLE patients. SLE patients have higher level of serum anti-ribosomal P0 antibody , specially in those with specific skin lesion.

Protective effect of olvanil against sulfur mustard-induced cutaneous injury / 国际药学研究杂志

Objective: To study the protective effects of olvanil on sulfur mustard (SM)-induced cutaneous injury. Methods: To establish mouse ear model of SM-induced cutaneous injury, KM mice right ears were exposed to 5 μl of 32 g/L or 128 g/LSM, respectively. Then we evaluated the protective effect of olvanil against SM-induced cutaneous injury with these two concentrations. For mice exposed to 32 g/L SM, olvanil (0.125, 0.25 and 0.5 mg/ear, topically) or indometacin (indomethacin, 10 mg/kg, po) were administrated 20 min or 30 min before SM exposure, respectively. After 24 h SM exposure, ear tissue was harvested and weighted, and the histopathological analysis was conducted. Similarly, for mice exposed to 128 g/L SM, olvanil (0.25 mg/ear, topically) or indomethacin (10 mg/kg, po) were administrated, and ear tissue was harvested and weighted. Results: Olvanil significantly inhibited 32 g/L SM-induced ear edema, cutaneous inflammation and necrosis, while no influence were observed on 128 g/L SM-induced cutaneous injury. Conclusion: Olvanil shows remarkable protective effect on cutaneous injury induced by SM of low concentration.

Incidence of Cutaneous Injury in Clinical Nurses / 기본간호학회지

PURPOSE: To identify the incidence of cutaneous injury in clinical nurses. METHOD: From Feb.1 to 28, 2005, 276 clinical nurses were surveyed by questionnaire. RESULTS: 1. Of the nurses, 53.6% had at least one incidence of cutaneous injury, and the mean number of injuries was 1.34. A higher incidence rate for cutaneous injury was found in nurses who were under the age of 25, unmarried and who had less than 3 years career experience. 2. The major causes of injury were syringe needles at 65.0%, and medical instrument were next followed by sharp objects or blades. The injuries occurred when the nurses were rearranging equipment after care (25.2%), taking blood samples (22.8%), separating syringes and needles (17.1%), during surgical operations (14.2%), and distribution of medications, treatments and recapping of needles (5.7% each). The hands were the most common body parts injured, and the most prevalent pathogens contaminating the instruments causing the injury were HBV, syphilis, HCV and HIV in that order. 3. Of the injured nurses, 77.9% did not report the accident and 25.8% did not receive any treatment because there were no pathogens, it was a bother or there was difficulty reporting the incident. CONCLUSION: To reduce cutaneous injuries, intensive training and supervision may be needed for those of nurses under the age of 25, unmarried and with less than 3 years career experience.