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Artículo en Inglés | WPRIM | ID: wpr-228910

RESUMEN

Copy number variation has been associated with various autoimmune diseases. We investigated the copy number (CN) of the DEFA1 gene encoding alpha-defensin-1 in samples from Korean individuals with Behcet's disease (BD) compared to healthy controls (HC). We recruited 55 BD patients and 35 HC. A duplex Taqman(R) real-time PCR assay was used to assess CN. Most samples (31.1%) had a CN of 5 with a mean CN of 5.4 +/- 0.2. There was no significant difference in the CN of the DEFA1 gene between BD patients and HC. A high DEFA1 gene CN was significantly associated with intestinal involvement in BD patients. Variable DEFA1 gene CNs were observed in both BD patients and HC and a high DEFA1 gene CN may be associated with susceptibility to intestinal involvement in BD.


Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Síndrome de Behçet/complicaciones , Dosificación de Gen , Predisposición Genética a la Enfermedad , Genotipo , Enfermedades Intestinales/etiología , Reacción en Cadena en Tiempo Real de la Polimerasa , alfa-Defensinas/genética
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