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OBJECTIVE To approach the flora distribution and drug-resistance status in deep fungal nosocomial infection in tumor patients and offer scientific evidence of prevention and controlling of it.METHODS Retrospective reviews were performed to analyze the 153 cases of deep fungal nosocomial infections in tumor department.Fungal cultivation,identification and susceptibility tests were performed strictly according to Rules of Operation in Clincal Laboratory of Nationwide.RESULTS The lower respiratory tract was the main site in deep fungal nosocomial infection in tumor patients,accounting for 61.4%.The digestive tract infection rated the second,accounting for 13.1%.Pathogenic bacteria mainly included Candida albicans(60.1%)and C.tropicalis(20.9%).The susceptibility test showed that the drug-resistance rate to amphotericin B and nystatin were all 0 and that to itraconazole and clotrimazole was 0-7.6%.The resistance rate(17.4-30.0%) to fluconazole showed upgrading tendency.CONCLUSIONS We should think highly of etiological detection and monitoring of drug-resistance in deep fungal nosocomial infections in tumor patients in order to control the infections effectively.
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OBJECTIVE To investigate the situation of hospital-acquired fungal infection of 75 cases with advaced lung cancer patients.METHODS The clinical information of deep fungal infection in 75 advanced lung cancer patients was investigated.The risk factors,the site and species were analyzed.RESULTS The lower respiratory tract and oral imfections accounted for 65.3% and 114.6% in 75 cases with deep fungal infections.Eighty-two stranins were isolated from various clinical specimens,in which Candida ailbicans and C.palasilosis accounted for 53.7% and 14.6%,respectively.CONCLUSIONS The rate of the deep fungal infection in advanced lung cancer patients is increasing.It is related to primary tumor,the amounts of white cells,invasive operation,age and use of antibiotics.
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OBJECTIVE To understand flora distribution and four antifungal drugs′in vitro antifungal activity of deep fungi in nosocomial infection in order to provide help to clinics.METHODS Fungi were cultured and isolated by routine procedure which identified by VITEK microbe automatic system.Drug susceptibility test used Rosco paper disk diffusion and broth dilution method with NCCLS M27-A.RESULTS Totally 156 strains with 9 species of deep fungi that main fungi were Candida albicans,and C.tropicalis with 57.69%,and 31.41%,respectively,were isolated from nosocomial infection.The major isolating rates of clinical infection specimens were from respiratory,cardiovascular surgery,and neurological departments with 26.28%,12.18%,and 9.62%,respectively.The main infection specimens were from respiratory tract and urinary tract with 71.15% and 16.67%,respectively.Drug resistance rates to fluconazole,amphotericin B,itraconazole,and ketoconazole with Rosco paper disk diffusion were 23.08%,2.56%,12.18%,and 17.36%,MIC90 were 64.0,2.0,8.0,and 16.0mg/L,respectively.CONCLUSIONS The main deep fungi are C.albicans and C.tropicalis.Antifungal activity of amphotericin B is the highest than others.The drug resistance rate to fluconazole is more and more higher.Clinics should use antifungal drug rationally in accordance with drug susceptibility test results.
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OBJECTIVE To investigate deep fungal hospital infection and methods of its decreasing. METHODS Case histories of near 3 years of hospitalized patients from Jan 2002 to Dec 2004 were analyzed according to Diagnosis Standard of Nosocomical Infection under the items,such as the patients,age,underlying disease,sample,strain,and species distribution. RESULTS There were 360 fungus strains belonged to 15 species in all samples;the patients age was 14-94 with 20 kinds of various underlying diseases;the fungi included Candida albicans,and C.tropicalis,accounted for 61.1% and 17.2%,respectively;the samples were sputum,urine,vaginal secretion,BLA,throat swab and pus,which were 42.2%,21.1%,13.9%,8.4%,5.8%,and 3.6%,respectively;the respiratory department,ICU,and urology department were mainly involved. CONCLUSIONS To prevent fungal infection, measures such as hospital′s environment and management including reasonable use of antibiotics play a great role in monitoring hospital fungal infection and its epidemiology.