RESUMEN
Objective To explore the effects of citalopram on interleukin-6 (IL-6) and brain derived neurotrophic factor (BDNF) in serum and cortisol in plasma of patients with depression syndrome.Methods 60 patients with depression in Kangci Hospital of Jiashan were randomly divided into two groups.31 cases in experimental group were treated with citalopram, 29 cases in control group were treated with imipramine.Levels of IL-6 and BDNF in serum and cortisol in plasma were compared pre-and post-treatment between two groups.Results Compared with pre-treatment, the levels of IL-6 and cortisol were lower(P<0.05), the level of BDNF was higher(P<0.05) post-treatment in two groups.Compared with control group, the levels of IL-6 and cortisol were lower(P<0.05), the level of BDNF was higher(P<0.05)in experimental group.Conclusion Citalopram has good curative effect on depression.The mechanism may be related to the decrease of IL-6 and cortisol levels, and the increase of brain derived neurotrophic factor level.
RESUMEN
Se realizó un estudio experimental, de tipo intervención terapéutica, en 35 pacientes con síndrome depresivo, atendidos en el Centro de Desarrollo de la Medicina Natural y Tradicional del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, desde agosto de 2010 hasta febrero de 2011, con vistas a determinar la efectividad de los remedios homeopáticos. En la serie predominaron las mujeres mayores de 35 años de edad (80,0 %), las enfermedades reumáticas y de la vía digestiva como antecedentes patológicos personales más comunes, acompañados de cansancio, fatiga y depresión, así como las alteraciones del sueño como síntomas psicológicos más frecuentes; asimismo, los remedios más usados resultaron ser: Natrum muriaticum, Aurum metallicum y Pulsatilla. La evolución favorable de los afectados puso de manifiesto la utilidad de esta terapia para disminuir la depresión.
An experimental study, of therapeutic intervention type was carried out in 35 patients with depressive syndrome, assisted in the Center of Development for Natural and Traditional Medicine at "Dr. Juan Bruno Zayas Alfonso" Teaching General Hospital in Santiago de Cuba, from August, 2010 to February, 2011, aimed at determining the effectiveness of the homeopathic remedies. In the series, women older than 35 years of age (80.0%), the rheumatic and digestive diseases as the most common pathological and personal histories prevailed, accompanied by fatigue, and depression, as well as the changes in sleep as the most frequent psychological symptoms; also, the most used remedies turned out to be: Natrum muriaticum, Aurum metallicum and Pulsatilla. The favorable clinical course of the affected patients showed the usefulness of this therapy to decrease depression.
Asunto(s)
Trastorno Depresivo , Homeopatía , Atención Secundaria de Salud , NaturopatíaRESUMEN
We used acupuncture therapy to treat a Diffuse Axonal Injury (DAI) patient who had developed delirium that persisted for many months after the traffic accident. The patient was diagnosed with mania-depressive syndrome from an oriental medical perspective, and was treated for blood stagnation and depression of qi and qiblood energy deficiency. The selected meridian points were Baihui, Dazhui, Geshu, Dazhu, Qimen, Taichong, and Zusanli, to Promote improvement of cyclical flow of qi to the brain through the Bladder Meridian and Gorvenor Vessel Meridian. As the early results of acupuncture therapy headache disappeared and the Sleep-Wake Schedule Disorder improved to normal. After 40 sessions of acupuncture therapy, that consciousness level improved and the Japan Coma Scale (JCS) score indicated “alert”. From these results, it was suggested that the cyclical flow of qi to the brain was improved and blood stagnation had disappeared, therefore the symptoms improved. Based on the result of this treatment for a DAI patient, we understood the importance of considering the brain as a meridian, individual from the body.