Desmoplastic trichoepithelioma complicated by sebaceous hyperplasia: a case report / 中华皮肤科杂志

A 67-year-old male patient presented with a plaque on the top of the head for more than 1 year.Physical examination showed an annular pale red plaque sized about 1.5 cm × 1 cm on the top of the head.It had a depressed center and papule-like elevated faint yellow boundaries,and there was no hair on the surface of the lesion.Histopathologic examination revealed milder epidermal hyperplasia,a small area of epidermal depression,confluence and hyperplasia of multiple sebaceous glands in the dermis,many keratinous cysts and funicular basophilic epithelial cells surrounded by hyperplastic collagen fibers in the superficial dermis.Immunohistochemical study showed positive staining for CD34 (hair mesenchymal cells),epithelial membrane antigen (EMA),cytokeratin 20 (CK20),but negative staining for bcl-2,P53,CD56 and collagen Ⅳ,with the proliferation index Ki-67 of 2％-5％.Based on the pathological results,the patient was diagnosed with desmoplastic trichoepithelioma complicated by sebaceous hyperplasia.

Imiquimod as an Adjuvant Treatment Measure for Desmoplastic Trichoepithelioma

Desmoplastic trichoepithelioma is a rare benign adnexal tumor. Although it is a benign lesion, patients often want to treat it due to cosmetic concerns when it occurs in an easily visible site. For our two cases, topical 5% imiquimod was an attractive treatment option as it is applied by the patients themselves and it has minimal side effects, including leaving no scar. However, the lesions recurred after clinical remission. To the best of our knowledge, this is the only report on utilizing imiquimod to treat a benign adnexal tumor, and especially desmoplastic trichoepithelioma.

A Case of Desmoplastic Trichoepithelioma / 대한피부과학회지

Desmoplastic trichoepithelioma is a rare, benign, adnexal tumor of hair follicle origin and is most commonly found on the face of young females. Clinically it presents as a solitary, asymptomatic, firm and annular plaque with a raised border. The histopathological findings show narrow strands of basaloid tumor cells with variable nests in a trabecular pattern and horn cysts in the desmoplastic stroma. This closely resembles morphea type basal cell carcinoma and microcystic adnexal carcinoma. We herein report a case of desmoplastic trichoepithelioma on the cheek of a 22-year-old man, with discussion of the significance of the immunohistochemical stains in the differential diagnosis of similar skin tumors, using antibodies for CD10, CD34, CEA, CK14, CK7 and Bcl-2.

A Case of Desmoplastic Trichoepithelioma, Showing Similar Histological Features to Microcystic Adnexal Carcinoma / 대한피부과학회지

Desmoplastic trichoepithelioma is a rare benign tumor which is most commonly found on the face of young females. The tumor has a raised, annular border and a depressed center. The histologic features are often confused with other skin diseases, especially with microcystic adnexal carcinoma. We report, herein, a case of desmoplastic trichoepithelioma in a 26-year-old man, confirmed by re-biopsy and CEA immunohistochemical study.

A Case of Desmoplastic Trichoepithelioma / 대한피부과학회지

Desmoplastic trichoepithelioma is a rare benign adnexal tumor of hair follicle origin. Clinically it is solitary, asymptomatic, white or yellowish and the center is frequently depressed, but not ulcerated. The three critical histologic features are narrow strands of tumor cells, keratinous cysts, and desmoplastic stroma. We present a case of desmoplastic trichoepithelioma in a 61-year-old man who had an asymptomatic, firm, annular nodule with a depressed center and an elevated border on the nose.

A Case of Desmoplastic Trichoepithelioma Associated with Syringomas / 대한피부과학회지

Desmoplastic trichoepithelioma is a rare benign adnexal tumor that usually presents as an asymptomatic, firm, annular plaque. It most commonly occurs on sun-exposed areas in middle-aged women, especially on the face. Patients typically give a history of a single, slow-growing lesion that has been present for several years. The diagnosis of desmoplastic trichoepithelioma can be made when a triad of microscopic findings are observed in combination with a compatible clinical picture. We herein report a case of desmoplastic trichoepithelioma associated with syringomas on the face of a young woman.

A Case of Desmoplastic Trichoepithelioma / 대한피부과학회지

Desmoplastic trichoepithelioma is a rare benign adnexal tumor with female preponderance, most commonly located on the face. Clinically, the tumor measures from 3 to 8mm in diameter, and has a raised, annular border and a depressed nonulcerated center. The three characteristic histologic features are narrow strands of tumor cells, horn cysts, and a desmoplastic stroma. We report herein a case of desmoplastic trichoepithelioma in a 25-year-old woman who had an asymptomatic hard annular nodule with a raised border and depressed center on the left cheek.

Desmoplastic Trichoepithelioma: A case report

Desmoplastic trichoepithelioma is a solitary tumor of the hair follicle with female preponderance, most commonly located on the face. Clinically, the lesions appear annular and firm with a raised border and a depressed nonulcerated center, but the appearance is not so distinctive to hair follicle tumors that definite diagnosis is established by the histopathologic findings. We report a case of desmoplastic trichoepithelioma in a 67-year-old woman who had an asymptomatic, hard, annular lesion measuring 0.8 cm in diameter, with a raised border and a depressed center on the right cheek. Histopathologic findings showed narrow strands of basaloid cells, horny cysts, and desmoplastic stroma, with the features corresponding to the desmoplastic trichoepithelioma.

A Case of Desmoplastic Trichoepithelioma / 대한피부과학회지

We report herein a case of desmoplastic trichoepithelioma in a 73-year-old female, who is the oldest among the patients of the disease reported in Korea. She had an asymptomatic, hard, annular lesion, measuring 0.6 x 0.7 cm with an elevated border and a depressed center on the left nasolsbial fold. Histopathological findings showed narrow strands of basaloid tumor cells, horn cysts and a desmoplastic stroma.

Desmoplastic Trichoepithelioma / 대한피부과학회지

We present a case of desmoplastic trichoepithelioma in a 21-year-old woman. She had a asymptomatic hard annular plaque with a raised border and depresaed center on the chin. Histopathological findings showed narrow strands of basaloid cell, keratinous cyst and desmoplastic stroma, the features corresponding to the desmoplaslic trichoepithelioma.