Supplementation with detox juice added with probiotic improves atherogenic parameters in healthy individuals

Abstract Phytochemicals present in detox juices and probiotics have demonstrated protective effects on cardiovascular risk factors. The consumption of these products alone modulate metabolic mechanisms and biomarkers. However, the effects of the combination of detox juice and probiotics have not yet been evaluated on atherogenic parameters. A randomized controlled study was carried out with 40 healthy volunteers (20 men and 20 women), aged between 18 and 50 years old. The volunteers ingested 200mL of juice for 30 days. Before and after supplementation, the anthropometric and lipid profiles and plasma concentrations of TBARS, Myeloperoxidase, Glutathione, Protein and non-protein Thiols and Vitamin C were analyzed. A reduction in LDL-c (p=0.05), triglycerides (p=0.05) and a significant increase in HDL-c (p=0.002) was observed. There was a significant decrease in the concentrations of TBARS (p=0.01), myeloperoxidases (p=0.02) and a significant increase in the Vitamin C and GSH (p=0.01). There wasn`t improvement in anthropometric parameters and total cholesterol. The findings highlight that supplementation with probiotic detox juice improves the lipid and antioxidant profile, suggesting a possible positive effect in reducing the risk of cardiovascular disease in healthy volunteers. Nevertheless, more robust researches with a prolonged treatment period should be conducted.

Análise da adequação do termo detox nos rótulos de bebidas industrializadas à base de frutas e vegetais / Analysis of the adequacy of the term detox on the labels of industrialized drinks based on fruits and vegetables

Dietas populares, como as detox, surgem a todo o momento. Todavia, poucos dados científicos comprovam a eficácia e segurança destas dietas. Este trabalho avaliou rótulos de bebidas à base de frutas e vegetais e identificou as que se autodenominam detox. Tratou-se de estudo transversal descritivo, realizado de setembro a outubro/2016. O tamanho da porção na informação nutricional e as alegações encontradas nos rótulos foram analisados em relação às legislações vigentes. Composição nutricional, quantidade total de ingredientes e presença de aditivos alimentares e/ou outros ingredientes não usuais em preparações culinárias foram comparados entre as bebidas detox e as comuns. De 83 produtos analisados, 9,6% (n=8) se autodenominaram detox. A composição nutricional e o número médio de ingredientes não diferiram entre as bebidas detox e as comuns. Alegações nutricionais e de saúde estavam presentes em 77,1% (n=64) dos produtos e 53,0% (n=44) apresentaram alegações não previstas na RDC nº 54/2012. As informações mais frequentes foram quanto aos teores de micronutrientes, açúcares, sódio e fibras. O termo detox, apesar de não permitido, é encontrado neste tipo de produto no mercado brasileiro. Os resultados sugerem que o termo detox seja utilizado mais como estratégia de marketing do que como real alegação de propriedade nutricional. (AU)

Popular diets, such as detox, appear all the time. However, few scientific data prove the efficacy and safety of these diets. This work evaluated labels of drinks based on fruits and vegetables and identified those that call detox. This was a descriptive cross-sectional study, carried out from September to October/2016. The portion size in the nutrition information and the claims found on the labels were analyzed in relation to the current legislation. Nutritional composition, total amount of ingredients and presence of food additives and other unusual ingredients in culinary preparations were compared between detox and ordinary drinks. Of 83 products analyzed, 9.6% (n=8) called detox. The nutritional composition and the average number of ingredients did not differ between detox drinks and ordinary drinks. Nutritional and health claims were present in 77.1% (n=64) of the products and 53.0% (n=44) presented claims not provided for in RDC nº 54/2012. The most frequent information was about the levels of micronutrients, sugars, sodium and fibers. The term detox, although not allowed, is found in this type of product in the Brazilian market. The results suggest that the term detox is used more as a marketing strategy than as a real claim of nutritional property. (AU)

Characteristic of the Hot Springs in the Izu Peninsula and Their Medical Consideration / 日本温泉気候物理医学会雑誌

<p>  In the European countries of advanced balneology, the hot spring treatments based on scientific grounds are provided widely in the hot spring hospitals and medical facilities under medical doctors. On the other, in our country the hot springs are mainly utilized as the source of “a feeling” such as hot spring cure, sightseeing, or leisure, but not used as a complementary treatment to modern medicine in order to enhance our health.</p><p>  The Izu Peninsula, a very limited area of Japan, consists of various strata due to the submarine volcanoes, the land volcanoes and the simple volcanoes. Those strata are distributed over the Izu Peninsula like a mosaic, and there are many hot springs on each stratum. Since such a place is very rare in the world, the Izu Peninsula is thought to be the most suitable place to investigate various hot springs scientifically.</p><p>  Thus I visited these spring resorts, obtained a hot spring analysis book (onsenbunsekisho) from each hot spring facility and clarified the characteristics of each hot spring based on the information from its analysis book. The present study shows that there are three kinds of hot springs in the Izu Peninsula: sulfate springs, chloride springs and simple hot springs. </p><p>  The origin of the sulfate springs in the old strata of Nishi-Izu and Naka-Izu is mainly due to the green tuff produced from the submarine volcanoes. The densities of sulfate ions in these springs are very high, suggesting their high pharmacological effects on several medical symptoms.</p><p>  In addition, the chloride springs in Mimami-Izu are hypertonic due to highly concentrated sodium ions, calcium ions and chloride ions, and thus expected to have detox effects on radioactive materials such as cesium 137 and strontium 90 by bathing in this type of spring.</p><p>  The simple hot springs in Nishi-Izu and Naka-Izu have the property of a sulfate spring, those in Higashi-Izu have the properties of sulfate and chloride springs, but those in Minami-Izu have many properties due to various negative ions such as hydrogen carbonate and carbonate. </p><p>  The future research themes for the establishment of balneology by using the hot springs in the Izu Peninsula are as follows:</p><p>  (1) Comparison of the chemical ingredients in the hot spring source water with those in its corresponding bathtub water; to examine changes in the physical and chemical properties of the water during the water-supply process.</p><p>  (2) Quantitative analyses of mineral components in the hot spring waters　suited fordrinking use; to find out existing amounts of the minerals in the antioxidant enzymes, and those of the minerals scarce in everyday life.</p><p>  (3) Establishment of indexes of the pharmacological effects of the sulfate springs by using laboratory animals or iPS cells; to evaluate scientifically the effects of the anions and cations in the sulfate springs on the animals or the cells.</p><p>  (4) Examination of the detox effect from bathing in the hypertonic chloride spring on cesium 137 and strontium 90; to find out the possibility of reducing the radiation exposure of the people exposed to the Fukushima nuclear power plant accident.</p><p>  (5) Examination of the protective effect of bathing in the simple hot springs on medical exposure disorders; to find out the possibility of preventing and mitigating the medical exposure disorders of exposed patients through radiation diagnosis and therapy. </p>

Characteristic of the Hot Springs in the Izu Peninsula and Their Medical Consideration / 日本温泉気候物理医学会雑誌

  In the European countries of advanced balneology, the hot spring treatments based on scientific grounds are provided widely in the hot spring hospitals and medical facilities under medical doctors. On the other, in our country the hot springs are mainly utilized as the source of “a feeling” such as hot spring cure, sightseeing, or leisure, but not used as a complementary treatment to modern medicine in order to enhance our health.  The Izu Peninsula, a very limited area of Japan, consists of various strata due to the submarine volcanoes, the land volcanoes and the simple volcanoes. Those strata are distributed over the Izu Peninsula like a mosaic, and there are many hot springs on each stratum. Since such a place is very rare in the world, the Izu Peninsula is thought to be the most suitable place to investigate various hot springs scientifically.  Thus I visited these spring resorts, obtained a hot spring analysis book (onsenbunsekisho) from each hot spring facility and clarified the characteristics of each hot spring based on the information from its analysis book. The present study shows that there are three kinds of hot springs in the Izu Peninsula: sulfate springs, chloride springs and simple hot springs.   The origin of the sulfate springs in the old strata of Nishi-Izu and Naka-Izu is mainly due to the green tuff produced from the submarine volcanoes. The densities of sulfate ions in these springs are very high, suggesting their high pharmacological effects on several medical symptoms.   In addition, the chloride springs in Mimami-Izu are hypertonic due to highly concentrated sodium ions, calcium ions and chloride ions, and thus expected to have detox effects on radioactive materials such as cesium 137 and strontium 90 by bathing in this type of spring.  The simple hot springs in Nishi-Izu and Naka-Izu have the property of a sulfate spring, those in Higashi-Izu have the properties of sulfate and chloride springs, but those in Minami-Izu have many properties due to various negative ions such as hydrogen carbonate and carbonate.   The future research themes for the establishment of balneology by using the hot springs in the Izu Peninsula are as follows:  (1) Comparison of the chemical ingredients in the hot spring source water with those in its corresponding bathtub water; to examine changes in the physical and chemical properties of the water during the water-supply process.  (2) Quantitative analyses of mineral components in the hot spring waters　suited for drinking use; to find out existing amounts of the minerals in the antioxidant enzymes, and those of the minerals scarce in everyday life.  (3) Establishment of indexes of the pharmacological effects of the sulfate springs by using laboratory animals or iPS cells; to evaluate scientifically the effects of the anions and cations in the sulfate springs on the animals or the cells.  (4) Examination of the detox effect from bathing in the hypertonic chloride spring on cesium 137 and strontium 90; to find out the possibility of reducing the radiation exposure of the people exposed to the Fukushima nuclear power plant accident.  (5) Examination of the protective effect of bathing in the simple hot springs on medical exposure disorders; to find out the possibility of preventing and mitigating the medical exposure disorders of exposed patients through radiation diagnosis and therapy.