Recommendations for Publishing Clinical Cases

The importance of publishing clinical cases lies in the diagnostic or therapeutic developments they can contribute. This paper mainly aims to guide young doctors in writing and publishing a clinical case. Reflections are encouraged on choosing a clinical case and writing it sharply, briefly, and chronologically to improve the chances of acceptance and publication. Recommendations on how to use the CARE (Case Report Statement and Checklist) are also given.

La importancia de la publicación de los casos clínicos radica en las novedades diagnósticas o terapéuticas que el mismo pueda aportar. Este trabajo está dirigido principalmente a los médicos jóvenes con la finalidad de orientarlos en el proceso de la redacción y publicación de un caso clínico. Se plantean reflexiones sobre cómo escoger un caso clínico, como redactarlo de una forma cronológica clara, nítida y breve, para mejorar las posibilidades de que sea aceptado y publicado. También se dan recomendaciones acerca de cómo utilizar la lista de comprobación CARE (Declaración y Lista de Comprobación-Case Report).

Towards a Constellation of Peaces and Developments in Colombia / Hacia una constelación de paces y desarrollos en colombia

RESUMEN Este artículo define una serie de argumentos que sustentan el vínculo estrecho entre las concepciones de paz y desarrollo, en procura de proyectar posibilidades de mayores impactos para el bienestar y la evolución humana. En el recorrido se dota a cada una de las nociones de diversos contenidos, dimensiones, atributos, dispositivos y propósitos con el fin de romper con su concepción unidimensional y dar paso a su constitución múltiple y compleja, para posteriormente definir puntos de encuentro, asocio, combinación y trabajo sinérgico entre las nociones en estudio que conlleven al reconocimiento de las paces y desarrollos circulando en una órbita más amplia. En el recorrido se reivindica las paces y desarrollos no solo como conceptos o nociones ideales, sino también como procesos, experiencias, dinámicas y acontecimientos múltiples que es necesario comprender en red. Para lograr tal reto se requirió realizar un análisis crítico de distintas revistas electrónicas, libros y declaraciones de las Naciones Unidas sobre desarrollo y paz con el fin de poder abrir el debate en lógicas de simbiosis, sinergias, complementariedades y contribuciones mutuales.

ABSTRACT This article defines a series of arguments that support the close link between the conceptions of peace and development, in an attempt to project possibilities of greater impacts on human well-being and evolution. In the journey, each of the notions is endowed with various contents, dimensions, attributes, devices, and purposes, in order to break with its one-dimensional conception and give way to its multiple and complex constitution, to later define meeting points, association, combination, and synergistic work between the notions under study that lead to the recognition of peace and developments circulating in a wider orbit. In the tour, peace and development are vindicated, not only as ideal concepts or notions, but also as processes, experiences, dynamics, and multiple events that must be understood online. To achieve this challenge, it was necessary to carry out a critical analysis of different electronic journals, books, and United Nations declarations on development and peace in order to open the debate on the logic of symbiosis, synergies, complementarities, and mutual contributions.

Mosaicismo sexual / Sexual mosaicism

RESUMEN Los trastornos del desarrollo sexual son estados congénitos en los cuales el desarrollo del sexo cromosómico, gonadal o anatómico es atípico. Por tratarse de un caso sumamente raro consideramos de interés su presentación. Se presenta adolescente masculino de 15 años, con antecedentes de genitales atípicos al nacer, desarrollo de baja talla y estigmas turnerianos, pubertad espontánea y normal. Los estudios genéticos determinaron como sexo cromosómico un mosaico 45,X/46,XY/47XYY, y sexo molecular varón. Se inscribió socialmente como varón, se le realizó cirugía de reconstrucción genital y utilizó tratamiento con hormona de crecimiento biosintética que mantiene actualmente. La evolución clínica ha sido favorable con adecuada integración social. Ante la presencia de genitales atípicos al nacer se necesita de un manejo multidisciplinario. El diagnóstico etiológico de los trastornos de la diferenciación sexual requiere de una alta pericia médica. Un tratamiento integral en estos pacientes les garantiza una buena calidad de vida(AU)

ABSTRACT Sexual development´s disorders are congenital states in which the development of the chromosomal, anatomic or gonadal sex is atypical. Since this is a very rare case, we consider it as of interests for presentation. It is presented a teenager, 15-years-old male, with a history of atypical genitalia at birth, development of short height and Turner's stigmas, and spontaneous and normal puberty. The genetic studies identified as chromosomal sex a mosaic 45,X/46,XY/47XYY and male as molecular sex. He was socially registered as a male, he had a genital reconstruction surgery and he was under treatment with biosynthetic growth hormone that he currently maintains. The clinical evolution has been favourable with adequate social integration. In the presence of atypical genitalia at birth, it is needed a multidisciplinary management. The etiological diagnosis of disorders of sexual differentiation requires a high level of medical expertise. A comprehensive treatment in these patients guarantees them a good quality of life(AU)

A Questionnaire Survey on General Status and Opinions about Clinical Mass Spectrometric Analysis in Korea (2018)

The Clinical Mass Spectrometry Research Committee (CMSRC), in affiliation with the Korean Society of Clinical Chemistry (KSCC), conducted a questionnaire survey on opinions about the general status of clinical mass spectrometric analysis in Korea. As a result, we understand that this field has passed through the introductory stage and is settled as a field of clinical laboratory testing in Korea, with the number of new laboratories performing mass spectrometric analysis being low. In spite of the many difficulties in introducing and operating clinical mass spectrometric analysis, there is a strong interest in this field, and even though further expansion is expected, there are still many issues to be resolved. In the future, it will be necessary to make concrete and thorough efforts to further develop the laboratory tests using clinical mass spectrometric analysis in Korea, centering on the CMSRC affiliated with the KSCC.

Research Progress of Omega-3 Polyunsaturated Fatty Acids in Regulating Blood Lipid and Atherosclerosis / 医药导报

Regulation of blood lipid and anti-atherosclerosis is a hot topic in the study of poly unsaturated fatty acids in recent years. Many research showed that polyunsaturated fatty acids can inhibit atherosclerosis by reducing lipid, anti-inflammatory,anti-oxidative, inhibiting thrombosis and protecting vascular endothelial cells. Polyunsaturated fatty acids, due to their medicinal and edible homologues,have great potential drugs for regulating blood lipids and anti-atherosclerosis.

Travessia e memória: considerações sobre o trabalho potências da fragilidade / Crossing and memory: considerations about the paper powers fragility

Nos apropriamos aqui, na intenção de comentá-lo, do título de trabalho de Tatiana Grinfeld, que, por meio de sua defesa de tese, fez uma exposição e um videoarte que mostram o enfrentamento da doença que a acometeu. Revelam-se as potências de um corpo que sofreu abalos e passou por situações traumáticas. Destacam-se questões sobre potência, vida e morte, tempo, memórias, bem como a busca de representação psíquica para tais experiências.

We consider here in the intention to comment on the title of Tatiana Grinfeld work, wich through a video-art and on her defense thesis expose the coping that her body went trought. They reveal the powers of a body that has suffered traumatic events. It highlights questions about power, life and death, time, memories, as well as the search for psychic representation for such experiences.

Research progress on tumor-vessel associated extravascular tumor metastasis / 中华消化外科杂志

The occurrence of malignant tunors is increasing annually around the world.In every year,8.2 million patients died of malignant tumors in which about 90％ patients died of malignant tumors associated multiple organs metastases.Inhibiting tumor metastasis is the key event to prolong the survival time of patients.With the further research,tumor-vessel associated extravascular tumor metastasis is playing an increasingly important role in the clinical application.This paper summarizes the new developments of tumor-vessel associated extravascular tumor metastasis to provide possible ideas for the therapy of malignant tumors.

Intelligent Facades in Low-Energy Buildings.

Growing interest in development of innovative solutions for enhancement of sustainability in the built environments has been observed in recent years. According to the main constituents of buildings particularly in building envelopes, facades are expected to play a significant role towards the promotion of sustainable design in low energy buildings. This study presents a holistic review towards the analysis of ‘intelligent facades’ according to their types, current implementations, challenges, and ultimate impacts. Intelligent facades need to be responsive and conscious to the local climate, outdoor environment, and indoor spaces with view to parameters such as energy performance, thermal comfort, indoor air quality, visual comfort, etc. The findings demonstrate that energy modeling and simulations should be performed during the early stage of design process of buildings to ensure the practicality and effectiveness of any green implementations in buildings. In conclusion, the study recommends the intelligent facades to become an inherent constituent of green buildings for future development of low energy buildings.

Algumas reflexões sobre a psicanálise, ontem e hoje / Algunas reflexiones acerca del psicoanálisis, ayer y hoy / A few thoughts on psychonalysis yesterday and today

A partir da conferência de Freud sobre suas perspectivas quanto ao futuro da terapia psicanalítica, a autora faz alguns comentários e reflexões sobre a prática clínica nos dias de hoje.

Desde la conferencia de Freud sobre las perspectivas para el futuro de la terapia psicoanalítica, el autor hace algunas observaciones y reflexiones sobre la práctica clínica actual.

From Freud's conference on prospects of the future of psychoanalytic therapy, the author makes some comments and reflections on clinical practice today.

Bases neuropsicológicas del desarrollo cognoscitivo entre el nacimiento y los doce años / Neuropsychological basis of the cognitive development from newborn to twelve years old

El presente artículo expresa una articulación teórica entre dos posturas clásicas que explican el desarrollo infantil,a partir de la relectura que se hace del modelo teórico de Jean Piaget, a la luz de los desarrollos planteados por la neuropsicología en la perspectiva del modelo de las unidades funcionales de Alexander Luria. En este sentido representa un ejercicio de reflexión que trasciende la sola descripción detallada de los estadios del desarrollo piagetianos entendidos desde la perspectiva cognitiva, hacia una comprensión más interaccionista de la relación que existe entre el cerebro y la cognición. [Montoya DM, González L. Bases neuropsicológicas del desarrollo cognoscitivo entre el nacimiento y los doce años. MedUNAB 2009; 12:157-174].

This paper shows a theoretical articulation between two basic postures that aim at explaining child development, from the reinterpretation of Jean Piaget's theoretical model. This is based upon the neuropsychology developments based upon Alexander Luria's functional units model. This is a reflection exercise that transcends the detailed description of the Piagetian development stages, as understood from the cognitive perspective, and aims at a more interactional understanding of the relationship between brain and cognition. [Montoya DM, González L. Neuropsychological basis of the cognitive development from newborn to twelve years old. MedUNAB 2009; 12:157-174].

Pancreatic Exocrine and Endocrine Cell Differentiation during Pancreatic Regeneration / 한양의대학술지

Pancreatic tissue is maintained by a simple proliferation of the preexisting cells in adulthood, whereas, they are dynamically derived from precursor/ stem cells from ductal epithelia during prenatal life. It has been known that tissue regeneration rarely occurs in the normal adult pancreas, particularly in the human pancreas. However, regeneration can be experimentally induced in the adult pancreas in response to various tissue injuries such as partial resection, pancreatitis by obstruction of the duct, and chemical insults. Regenerating pancreatic tissue shares a common morphogenic feature of "neogenic regeneration" in all regenerating animal models. Neogenic regeneration occurs at the site of tissue injury by forming small tubular structures with elongated epithelial cells (ductules) which grow to form pancreatic ducts and acini. The endocrine cells, including insulin secreting beta cells, are also derived from these ductules. As a sequential process of neogenesis, the regenerating tissue becomes heterogeneous in composition. Some areas were composed by tubules and ductules in surrounding loose connective tissue while others were denser with differentiating acini derived from tubules or ductules. Such neogenic regeneration mimics tissue development during fetal pancreatic organogenesis. In the process of pancreatic neogenesis, we found unique expressions of bioactive proteins such as nestin and clusterin as morphogenic factors. It is likely that the stem/precursor cells could be recapitulated and regenerated to functional cells, including endocrine and exocrine pancreatic cells with acinar and ductal cells during neogenic regeneration of the pancreas.

Superficial Cutaneous Mycoses in Korea / 한양의대학술지

Superficial cutaneous mycosis is mycotic infection of the epidermis of the skin, and one of common dermatoses in Korea. They have close relationship between host (human) and fungi. Their clinical patterns and incidence, and their causative fungi may change with social environments and life patterns. Since 1945, GNP has been increased explosively, more than 243 folds, and economic developments brought abrupt changes of social environments and life patterns in Korea. Furthermore, there had been great social events during this period; Korean War in 1950-1953, the Asian Game in 1986, the Olympic Game in 1988 and the World Cup in 2002. Those events gave much chances for dermatophytes to move and change. Tinea pedis is the most common dermatophytosis and has been increased from 26% of all dermatophytosis in late 1950s to 40.9-42.2%. And tinea unguium(onychomycosis) has been increased as tinea pedis does; Its proportion was 2.8% in late 1950s, and 17% in 1990s. The patients with tinea pedis have high family infection rate and also have high coexisting dermatophytosis. The most common isolate was Trichophyton(T.) rubrum, followed by T. mentagrophytes and Epidermophyton floccosum. Tinea capitis showed the most dramatic changes; its incidence was the highest just after Korean war and decreased abruptly since 1970s. Microsporum(M.) ferrugineum was the most common isolates till 1970s, and abruptly decreased and now nearly disappeared. Trichophyton(T.) violaceum was isolated in Cheju island. After Korean war, T. schoenleinii was isolated from favus and is disappeared. M. canis was isolated for the first time in 1959 and has been the most common isolates since late 1970s. T. verrucosum was isolated in 1986, and T. tonsurans was isolated for the first time in 1995 and spread among wrestlers, Judo players and Korean wrestlers. It might be imported by wrestlers with sport exchanging program. In cidence of tinea cruris was dramatically changed and was 5% of all dermatophytosis in 1940s, and 26.6-39.1% in 1990s. Those changes might be related to change of life patterns. Proportion of cutaneous candidiasis among superficial cutaneous mycosis was 1.9% in 1960s, 6.7% in 1973, 14.6% in 1976-1985, and 7.4% in 1989-1992. Proportion of pityriasis versicolor among superficial cutaneous mycosis was 12.1% in 1973, 7.7% in 1976-1985, and 7.7% in 1989-1992. Research for Malassezia have been increasing since late 1990s and that will bring us many new informations.

Changing Patterns of Dermatophytosis and Its Causative Agents according to Social and Economic Developments in Korea / 대한의진균학회지

Deramtophytosis is one of common dermatoses and occupied 10~20% of all dermatologic outpatients in Korea. It has close relationship between host (human) and dermatophytes. Their clinical patterns and incidence, and their causative dermatophytes may change with social environments and life patterns; Some dermatophytes may decrease or disappear and others can be imported from other countries. During recent 60 years, GNP has been increased explosively, more than 190 folds, and that economic developments brought abrupt changes of social environments and life patterns in Korea. Furthermore, there had been great social events; Korean War in 1950~1953, the Asian Game in 1986, the Olympic Game in 1988 and the World Cup in 2002. Those events gave much chances for dermatophytes to move and change. Trends of clinical types of dermatophytosis and their causative dermatophytes were evaluated with reported articles during the period. Tinea capitis showed the most dramatic changes. Its incidence was the highest just after Korean war, 24.5% of all primary school students, and decreased abruptly by 26.5% of all dermatophytosis in late 1950s, 4.9% in late 1960s, and 2~4% since 1970s. Microsporum(M.) ferrugineum was the most common isolates till 1970s, and abruptly decreased and now nearly disappeared. Trichophyton(T.) violaceum was isolated in Cheju island. After Korean war, T. schoenleinii was isolated from favus and disappeared. M. canis was isolated for the first time in 1959 and has been the most common isolates from tinea capitis since late 1970s. T. verrucosum was isolated for the first time in 1986 in Kwangju and has been isolated nation-widely. T. tonsurans was isolated for the first time in 1995 in Daegu and spread among wrestlers, Judo players and Korean wrestlers. It might be imported by wrestlers with sport exchanging program. Tinea pedis is the most common dermatophytosis in Korea now. It was 26% of all dermatophytosis in late 1950s, and increased by 40.9~42.2% in 1970s. And tinea unguium has been increased as tinea pedis does; It was 2.8% of all dermatophytosis in late 1950s, and increased by 5.1~14.2% in 1970s, 5.5~15.3% in 1870s and 17% in 1990s. The patiets with tinea pedis have high family infection and also high coexisting dermatophytosis. The most common isolate was T. rubrum, followed by T. mentagrophytes and Epidermophyton floccosum. Tinea cruris was one of dramatically changed dermatophytosis. Its incidence was 5% of all dermatophytosis in 1940s, and increased by 10.2% in late 1950s, and 26.6~39.1% in 1970s. Environments and socioeconomic conditions are changing, and international travel and sports exchanging program are increasing. All those social events may cause new dermatophytes to invade from other countries. We should check it carefully and continuously.

Mechanism of apoptosis in hippocampus of the rats with disorder of cortical developments / 重庆医科大学学报

Objective:To study the mechanism of apoptosis in hippocampus of the rats with disorder of cortical developments.Methods:The Rats with disorder of cortical developments were established by carmustine(BUCN).AT P0,P15,P30,P45,P60,the number of apoptosis cell and expression of Bax and Bcl-2 in hippocampus were detected by TUNEL,immunohistochemistry method and RT-PCR;then the detected outcomes were analyzed by computer micrograph analysis system in control group and model group.Results:At P15,P30,P45,P60,the numbers of apoptosis,Bax,Bcl-2 masculine cell and bcl-2 MRNA,bax MRNA in hippocampus in the model group were more than those in the control group.The ratio of Bax/Bcl-2 in model group was significantly higher than those in the control group(P