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The pathogenesis of diabetic cystopathy(DCP)is complex and early diagnosis is hindered by a lack of specific and sensitive criteria and more research is needed to establish guidelines for its clinical diagnosis and treatment.Exosomes are membrane vesicles carrying various biological information such as proteins and nucleic acids, which are critical for communication between different tissues and organs.This review discusses the potential role of exosome miRNA in the pathogenesis of DCP and its application in therapy, aiming to provide new insight into the diagnosis and treatment of DCP.
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Objective:To investigate the quality of life of diabetes patients managed by the“1+1+1”contracted family physician services and to analyze the influencing factors.Methods:A survey on quality of life of diabetic patients in the community was conducted in Shanghai Huacao township from July 2018 to September 2018. A total of 413 residents managed by the contracted family physician services in 3 villages of Huacao township were selected by stratified cluster random sampling as study subjects, including 203 diabetes patients and the 210 healthy subjects (control group). The self-prepared questionnaire was applied for survey of general information and the quality of life was evaluated with the MOS 36-item short form health survey (SF-36) in two groups. The linear stepwise regression model was deployed to analyze the factors related to the quality of life of diabetes patients.Results:The total scores of SF-36 were (711.36±103.40) and (736.72±85.42) in diabetic group and control group, respectively. The total score and the scores of reported health transition, physical function, general health, physiological contents in diabetic group were significantly lower than those of control group ( t=-2.712, -2.326, -4.872, -5.509, -3.504, P<0.05); however, there were no significant differences in role-physical, bodily pain, role-emotional, mental health, vitality, social function, and psychological contents between the two groups ( P>0.05). The univariate regression analysis indicates that age, educational degree, score on the quality of sleep, stressful life event, usual mental state, and the years of contracted family doctor service were associated with the quality of life of diabetes patients ( t/ F=3.373, 3.216, 5.716, 58.146, 28.325, 14.450, P<0.05). Stepwise multiple linear regression analysis showed that stressful life event, usual mental state, and the years of contracted family doctor service were the independent factors related to the quality of life in diabetes patients ( t=7.157, 4.741, -2.779, 2.129, P<0.05). Conclusion:Under the“1+1+1”contracted family doctor service mode, the quality of life of diabetes patients in the community is very close to that of the healthy population in several dimensions. The study has also revealed that the duration of contracted family physician service and other factors can influence the quality of life of diabetic patients.
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@#ObjectiveTo study the effects of aqueous extract of Trigonella foenum-graecum(AET) on the blood glucose in normal and alloxan(ALX)-diabetic mice.MethodsFasting blood glucose and glucose tolerance in normal and ALX-diabetic mice were measured respectively 7 days after AET had been given.ResultsAET had not significantly effected the fasting blood glucose of normal mice, but improved their glucose toleranc. Otherwise, AET reduced fasting blood glouse of diabetic mice induced by ALX significantly.ConclusionAET can be used on treatment of diabetes mellitus.
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Objective: To study the effects of smoking or diabetes on the level of aspartate aminotransferase in gingival cervical fluid (GCF-AST).Methods: Periodontal disease index(PDI) and GCF-AST were measured and compared in 105 smokers,86 patients with diabetes and 90 healthy controls.Results: The PDI values in smokers and diabetes patients were higher than that in controls (P