Correlation analysis between type 2 diabetes mellitus with hypertension and certain serum elements levels / 公共卫生与预防医学

Objective To investigate the correlation between the incidence of type 2 diabetes mellitus (T2DM) with hypertension and the levels of some elements in serum, and to provide a more scientific and reasonable basis for the control of T2DM. Methods A total of 1 024 T2DM patients admitted to a top three hospital in Urumqi from March 2015 to May 2016 were selected. Patients with T2DM were divided into T2DM with hypertension group and T2DM without hypertension group according to the presence or absence of hypertension. Various elements levels in the serum were analyzed. The correlation between serum levels and the incidence of hypertension with T2DM was analyzed, and the related risk factors were explored by using logistic regression. Results Among 1 024 T2DM patients, 627 patients had hypertension, accounting for 61.20%, while 397 patients had no hypertension, accounting for 38.80%. There was a positive correlation between serum sodium and magnesium levels with T2DM in hypertension (P<0.05). The increase of serum sodium level and the decrease of magnesium level were the risk factors of T2DM with hypertension. This result suggested that the difference of serum levels of various elements may play a role in the occurrence and the development of T2DM. Conclusions Serum sodium and magnesium levels were positively correlated with the incidence of T2DM with hypertension. The increase of serum sodium level and the decrease of magnesium level were influencing factors of the incidence of T2DM with hypertension. This study suggests that the serum levels of sodium and magnesium play a role in the occurrence and development of T2DM.

Independent and joint effect of brachial-ankle pulse wave velocity and body mass index level on incident diabetes with hypertension / 中华内分泌代谢杂志

Objective To investigate whether brachial-ankle pulse wave velocity(baPWV),independently and jointly with the level of body mass index(BMI),affect the risk of incident diabetes with hypertension. Methods The effects of baPWV and BMI level on incident diabetes with hypertension were evaluated using Kaplan-Meier curves (log-rank test) and multi logistical regression models after adjustment for various confounding factors. Results A total of 2 222 participants were recruited in this study. Higher baPWV (Q4) was associated with a greater risk of incident diabetes with hypertension simultaneously compared with baPWV in the lower quartiles(Q1-Q3),with HR 4.16(95% CI 2.14,8.09)in the crude model,2.52(95% CI 1.10,5.78) in modelI,and 2.45(95% CI 1.05, 5.70)in modelⅡ.The highest risk of diabetes with hypertension simultaneously was in the group with high baPWV and BMI≥25 kg/m2,with HR 11.50(95% CI 4.5,29.9)in the crude model,4.20(95% CI 1.4,13.1)in modelI,and 4.30(95% CI 1.4,13.3) in modelⅡ. Conclusions The joint effect of baPWV and BMI level on incident diabetes with hypertension simultaneously is a better predictor than their independent effect. The risk of incident diabetes with hypertension markedly increases in the subjects with BMI≥25 kg/m2and higher baPWV.

Effect of Long-Term Systolic Blood Pressure Trajectory on Kidney Damage in the Diabetic Population: A Prospective Study in a Community-Based Chinese Cohort / 中华医学杂志(英文版)

<p><b>Background</b>Previous studies have shown that hypertension is an important factor contributing to the occurrence and progression of diabetic kidney damage. However, the relationship between the patterns of blood pressure (BP) trajectory and kidney damage in the diabetic population remains unclear. This prospective study investigated the effect of long-term systolic BP (SBP) trajectory on kidney damage in the diabetic population based on an 8-year follow-up community-based cohort.</p><p><b>Methods</b>This study included 4556 diabetic participants among 101,510 participants. BP, estimated glomerular filtration rate (eGFR), and urinary protein were measured every 2 years from 2006 to 2014. SBP trajectory was identified by the censored normal modeling. Five discrete SBP trajectories were identified according to SBP range and the changing pattern over time. Kidney damage was evaluated through eGFR and urinary protein value. A multivariate logistic regression model was used to analyze the influence of different SBP trajectory groups on kidney damage.</p><p><b>Results</b>We identified five discrete SBP trajectories: low-stable group (n = 864), moderate-stable group (n = 1980), moderate increasing group (n = 609), elevated decreasing group, (n = 679), and elevated stable group (n = 424). The detection rate of kidney damage in the low-stable group (SBP: 118-124 mmHg) was the lowest among the five groups. The detection rate of each kidney damage index was higher in the elevated stable group (SBP: 159-172 mmHg) compared with the low-stable group. For details, the gap was 4.14 (11.6% vs. 2.8%) in eGFR <60 ml·min·1.73 m and 3.66 (17.2% vs. 4.7%), 3.38 (25.0% vs. 7.4%), and 1.8 (10.6% vs. 5.9%) times in positive urinary protein, eGFR <60 ml·min·1.73 m and/or positive urinary protein, and eGFR decline ≥30%, respectively (P < 0.01).</p><p><b>Conclusion</b>An elevated stable SBP trajectory is an independent risk factor for kidney damage in the diabetic population.</p>

The Effect of Diabetes with Hypertension on Glucose, Lipid Metabolism and Renal Function / 中国医师杂志

Objective To investigate the influence of the diabetes with hypertension on glucose and lipid metabolism as well as renal function. Methods 310 diabetic inpatients were divided into hypertension group (n=150) and non-hypertension group (n=160). The levels of plasma glucose, insulin, C-peptide, lipid and creatine, as well as microalbuminuria were measured. The results were statistically analyzed. Results Compared with non-hypertension group, in hypertension group the plasma levels of fasting glucose and postprandial glucose significantly increased (P