Study on some factors incluencing on the effectiveness of semi-synthesis of fluoroalkyl ethers of dihydroartemisinine

The study examined some factors (solvent, catalysis, temperature) affecting to fluoroalkyl ether subsynthesis effects of dihydroartemisinin. TF-DHA and PF-DHA, two fluoroalkylether derivatives of dihydroartermisinin was prepared by treatment of dihydroartermisin with appropriate fluoroalcohol in the presence of boron trifluoride etherate. The dicloromethan solvent is most efficient option for TF-DHA's preparation

Therapeutic efficacy of dihydroartemisinin-piperaquin combination in malaria treatment in Vietnam

Therapeutic efficacy of dihydroartemisinin (DHA) - piperaquin in treatment of P falciparum and P. vivax was investigated in the National Institute of Malariology, Parasitology and Entomology (NIMPE), Hospital of Tropical Diseases in Ho Chi Minh city. Hospital inpatients and patients in primary health care facilities were enrolled in the study. Four small scale clinical studies were conducted and followed by large scale treatment studies in the Hospital of Tropical Diseases and primary health care services in the provinces of Binh Phuoc, Dak Lak, Quang Tri during the period 2001 - 2004. A total number of 3,978 malaria patients (989 P. vivax and 2,999 P falciparum were sampled

Study on the improvement of method of semi synthesis of some water soluble aromatic ethers of dihydroartemisinine

Artelinic acid (6d) and Metaartelic acid (8), water soluble dihydroartemisinin derivatives with antimalarial activity, were prepared by direct etherification of dihydroartemisinin (2) with appropriate hydroxymethyl z=benzoic acid.

Study on the solid dispersion system of dihydroartemisinine and application to the galenic form of suppository

The solid dispersion system (SDA) of dihydroartemisinine (DHA) with PEG 400, PEG 1540, PEG 4000, PEG 6000 and Tween 20, cremophor EL, PEG 400 stearate as cocarrier were prepared. the experimental results showed that the release rate of DHA from suppository base was greater than the semi-synthetic triglyceride base and the physico-mixture

Study on the influence of dihydro-artemisinine on the biochemical, hematological index of experimental animals

Dihydro-artemisinine (DHA) is a derivation of artemisinine, which is used on the rabbit with 20mg/kg/day in 28 days. The results shown that amount of erythrocytes, leukocytes and hemoglobin level weren't changed. Levels of SGOT, SGPT, creative were not significantly changed compare with placebo. Therefore, DHA didn't influence on the biochemical, hematological index in experimental rabbits