RESUMEN
Aims@#The objective of this research was to study the effect of bio-liquid organic fertilizer on the growth of Dipterocarpus alatus Roxb seedlings (30 days old) in the pot experiment. @*Methodology and results@#For the production of bio-liquid fertilizers, distillery slop; molasses and bio-methane waste water were fermented with plant growth promoting bacteria, which had potentials for nitrogen fixing, phosphate solubilizing and potassium solubilizing properties. It was found that treatment no. 13 (molasses + three bacterial isolates (PGPB), 30 days of fermentation) presented the best result on the growth parameters of D. alatus Roxb including root length (21.67 cm), shoot height (20.33 cm), root fresh weight (1.49 g), shoot fresh weight (3.61 g) and total biomass (4.13 g). Moreover, using liquid organic fertilizer produced from molasses supplemented with bacteria had higher growth-promoting effects on D. alatus than the effective microorganisms (EM). @*Conclusion, significance and impact of study@#To covert agricultural residues to the valuable product was the aim of this work. In our experiment, we found that molasses and bio-methane waste water were suitable for using as a material to produce liquid organic fertilizers which were beneficial for promoting growth of D. alatus seedlings.
RESUMEN
The present study was designed to examine the anti-hyperuricemic and anti-inflammatory effects and possible mechanisms of vaticaffinol, a resveratrol tetramer isolated from ethanol extracts of Dipterocarpus alatus, in oxonate-induced hyperuricemic mice. At 1 h after 250 mg·kg potassium oxonate was given, vaticaffinol at 20, 40, and 60 mg·kg was intragastrically administered to hyperuricemic mice once daily for seven consecutive days. Vaticaffinol significantly decreased serum uric acid levels and improved kidney function in hyperuricemic mice. It inhibited hepatic activity of xanthine dehydrogenase (XDH) and xanthine oxidase (XOD), regulated renal mRNA and protein levels of urate transporter 1 (URAT1), glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1), organic cation transporter 1 (OCT1), OCT2, organic cation/carnitine transporter 1 (OCTN1), and OCTN2 in hyperuricemic mice. Moreover, vaticaffinol markedly down-regulated renal protein levels of NOD-like receptor 3 (NLRP3), apoptosis-associated speck-like (ASC), and Caspase-1, resulting in the reduction of interleukin (IL)-1β, IL-18, IL-6 and tumor necrosis factor-α (TNF-α) levels in this animal model. Additionally, HPLC and LC-MS analyses clearly testified the presence of vaticaffinol in the crude extract. These results suggest that vaticaffinol may be useful for the prevention and treatment of hyperuricemia with kidney inflammation.