RESUMEN
Hypophosphatemic rickets is a disorder of renal tublular reabsorption of phosphorus,which resulting in bone dysplasia.It is characterized by hypophosphatemia,rickets and limb deformity.Hypophosphatemic rickets may be mainly due to congenital / genetic or secondary to the tumor and other renal tubular disease.Phosphorus is an important element in cell metabolism.Extracellular phosphorus ions maintain the phosphorus concentration at a low level by dietary absorption,kidney regulation and various phosphorus-regulating factors.With the development of molecular biological technologies,forms of renal phosphate wasting diseases have been identified in past years,and FGF23 plays an important role in the disease mechanism.This review aims to overview the studies of the treatment and physiopathology of hypophosphatemic rickets and to enhance the recognition of hypophosphatemic rickets.