Preparation and in vitro Dissolution of Ambroxol Hydrochloride Double-layer Tablets / 中国药师

Objective:To study the preparation technology of ambroxol hydrochloride double-layer tablets and evaluate the drug re-lease in vitro. Methods:The best technology was screened by orthogonal design, and the drug release in vitro was evaluated by UV spectrophotometry. Results:The drug release in vitro was in accordance with the corresponding standard. Conclusion:The preparation technology is simple and the quality is stable for industrial production.

Drug release of Compound Salvia Multi-component released Double-layer Tablet / 中成药

AIM: To establish the drug release method of Compound Salvia Multi-component released Doublelayer Tablet and investigate its in vitro drug release behavior and the influencing factors of the drug release rate.METHODS: The method of evaluating in vitro release rate of double-layer tablet was established with salvianolic acid B and gindenoside Rg_1 as index,The influencing factors of the release of rapid release layer and sustained release layer of double-layer tablet and their in vitro drug release behavior were studied.RESULTS: The rapid release layer showed the quick releasing effect; The drug release curve of sustained release layer accorded with Ritger-Peppas equation; artificial gastric juice had significant effect on the release curve of gindenoside Rg_1 which in double-layer tablets,but had no significant effect on the release curve of salvianolic acid B.CONCLUSION: The evaluation of in vitro release rate of Compound Salvia Multi-component released Double-layer Tablet shows good properties of fast and sustained release and clinic application is achieved.

Preparation of Huperzine A Double-layer Sustained Release Tablets and Their in Vitro Release Characteristics / 中国药房

OBJECTIVE: To study the preparation of Huperzine-A double-layer sustained release tablets and their in vitro release characteristics.METHODS: With HPMC K4M as matrix and lactose as diluting agent for the sustained release layer,and with starch-calcium carbonate as diluting agent and sodium carboxymethyl starch as disintegrating agent for the fast release layer to prepare the double-layer tablets by compression,with the release rate of the compressed tablets determined by HPLC.RESULTS: The fast release layer of the prepared Huperzine-A double-layer tablets disintegrated within 1～2 min and appeared as fine powder,meeting the requirement;the release curve of the sustained release layer of the tablets was in line with Higuchi equation and maintained a sustained release of 12 hours.CONCLUSION: The prepared Huperzine-A double-layer tables achieved the goal of both immediate release and sustained release.

Preparation of Shichangpu Double Layer Tablets / 中草药

Objective To prepare Shichangpu Double Layer Tablets. Methods The release of the sustained-release layer (SRL) was used as the response parameters and uniform design with alterable levels was used to optimize the recipe of SRL of Shichangpu Double Layper Tablets. Fast-release layer (FRL) was made from water extraction by ultra-filtration. Results The dissolution kinetics of SRL could follow zero-order equation and FRL showed good prosperities for fast release in 10 min. Conclusion The in vitro release of SRL of Shichangpu Double Layer Tablets testifies the significant sustained release action and FRL disintigrates rapidly. The preparation technology of Shichangpu Double Layer Tablet is reliable and simple.