RESUMEN
OBJECTIVE To study the changes in drug resistance and distribution of Pseudomonas aeruginosa to guide drug treatment in clinic.METHODS P.aeruginosa was identified by API and VITEK2 system,and its antimicrobial ressistance was determined by Kirby-Bauer method.The antimicrobial ressistance rates were analyzed by WHONET 5.4 software.RESULTS The resistance of P.aeruginosa to 12 antibiotics was increased in the past nine years.The resistant rate to meropemem,imipenem,ciprofloxacin and ceftazidime was below 30%.Among 2127 strains of P.aeruginosa,94 strains were identified multi-drug resistant and found more frequently in ICU,and Respiratory Department.CONCLUSIONS P.aeruginosa is resistant to many kinds of antimicrobial agents,and resistant rate is increasing year by year.In order to control and slow down the occurrence of the resistant strains,it should be more careful to choose antimicrobial agents according to the antimicrobial susceptibility test.