A Case of Dyschromatosis Universalis Hereditaria Treated with a Q-switched Nd:YAG Laser / 대한피부과학회지

Dyschromatosis universalis hereditaria is a rare pigmentary disorder that's characterized by the presence of both small and irregular sized hyperpigmented and hypopigmented macules in a generalized distribution. The pattern of inheritance is thought to be autosomal dominant, but some sporadic and autosomal recessive inheritance cases have also been reported. We report here on a case of a-15-year old female patient with dyschromatosis universalis hereditaria, which is compatible with autosomal dominant inheritance. The patient presented with numerous small and irregularly sized hyper-and hypopigmented macules on her face, trunk and both the arms and legs, but not on the palms and soles. By analysis of her familial pedigree, we found an autosomal dominant pattern of inheritance. The biopsy specimen taken from the hyperpigmented macules showed increased melanin granules and pigmentation in the basal cell layer of the epidermis. Various therapeutic trials have been introduced to treat these lesions, but there have been few reports of simple effective treatments for the hyper-and hypopigmented lesions. So, we tried treating the hyperpigmented macules with a Q-switched Nd:YAG laser and we obtained a successful result.

Dyschromatosis Universalis Hereditaria / 대한피부과학회지

Dyschromatosis universalis hereditaria is a rare pigmentary disorder characterized by widespread mothed hyperpigmentation and hypopigmentation. We report a 40-year-old male patient with numerous hyperpigmenter, and hypopigmented macules all over the body except on the palms and soles. The family history revealed similar pigmentary changes in 5 other members through 4 generations, and we could guess the hereditary pattern of the disease of this family to be autosomal dominant inheritance.

Dyschromatosis Universalis Hereditaria

Dyschromatosis universalis hereditaria is a rare pigmentary disorder initially described in the Japanese literature. The pattern of inheritance is believed to be autosomal dominant, but many sporadic cases have been reported. We encountered a family in which dyschromatosis universalis hereditaria occurred in seventeen members of three generations. In the two members whom we observed, typical skin lesions were distributed all over the body except palrns and soles. By pedigree analysis, we found an autosomal dominant pattern of inheritance. The differential diagnosis of the other reticulate pigmentary disorders is discussed with a review of dyschromatosis reported in the Korean literature.