RESUMEN
Based on the general goal of the medium and long term development of basic science from 2021 to 2035 and the "14th Five-Year Plan" in China, combined with the national strategic needs, this paper discusses the five priority development areas of endemiology according to the development trends and characteristics of endemiology in the next 5 - 15 years. The five areas are study on the pathogenesis and prevention measures of endemic fluorosis; study on risk assessment, pathogenic mechanism and control strategy of environmental arsenic exposure; research on the basis and application transformation of the pathogenesis of iodine nutrition-related diseases; molecular mechanism and targeted intervention of cartilage injury in Kashin-Beck disease; precise prevention and treatment, preservation of biological samples and etiology study of Keshan disease. Combined with the scientific significance and national strategic needs of various field, the authors analyze its main study directions and core scientific issues.
RESUMEN
According to the general goal of long term development of basic science from 2021 to 2035 and the "14th Five-Year Plan" in China, starting from the reasearch characteristics and the basic situation of endemiology, this study discusses the strategic position, development law, development trend, development status and layout, development goals and realization ways of endemiology, combined with the strategic needs of the discipline, the important interdisciplinary research areas of endemiology are put forward. The purpose of this study is to promote the rapid development of basic research on endemic diseases, to provide reference for the scientific and technological layout and policy formulation of the endemiology, to provide reference for the "14th Five-Year Plan" in China, and to provide guarantee for the people in the sick area to seek health.
RESUMEN
Objective To understand the review situation of medical ethics in scientific research and prevention and control of endemic diseases,raise awareness of ethical review,and to promote rapid and healthy development in scientific research for control of endemic diseases.Methods The method of retrospective analysis was used,articles on original articles,field epidemiological investigations and clinical medicines published by Chinese Journal of Endemiology from 2013 to 2016 were collected.Examination of medical ethics in national,provincial and municipal fund programs and non fund projects was carried out.Statistical analysis was performed using Cochran-Armitage trend test and Cochran-Mantel-Haenszel (CMH) test.Results A total of 642 articles were collected from 2013 to 2016 and 25 articles were excluded.①The total number of papers published after medical ethics review was in a upward trend,the difference was statistically significant in trend test (Z =4.84,P ＜0.01);and the papers were increased from 14.8％ (20/135) in 2013 to 38.2％ (66/173) in 2016 and compared among different years,the differences were statistically significant (x2 =23.43,P ＜ 0.01).The papers of original articles and field epidemiological investigations published were in a upward trend,the difference was statistically significant in trend test (Z =4.32,2.14,P ＜ 0.01 or ＜ 0.05);and the papers were increased from 12.3％ (7/57),13.2％ (9/68) in 2013 to 48.6％ (36/74),27.3％ (24/88) in 2016 and compared among different years,the differences were statistically significant (x2 =18.61,4.57,P ＜ 0.01 or ＜ 0.05).②The total number of papers published which was supported by various fund programs that had past the medical ethical review was in a upward trend,the difference was statistically significant in trend test (Z =5.27,P ＜ 0.01);and the papers were increased from 13.3％ (14/105)in 2013 to 42.4％ (53/125) in 2016,compared among different years,the differences were statistically significant (x2 =27.69,P ＜ 0.01).The total number of papers published in the national,provincial programs was in a upward trend,the difference was statistically significant in the trend test (Z =4.14,3.21,P ＜ 0.01);and the papers were increased from 16.0％ (8/50),10.0％ (5/50) in 2013 to 51.7％ (31/60),32.7％ (17/52) in 2016,compared among different years,the differences were statistically significant (x2 =17.05,10.27,P ＜ 0.01).③The total number of papers published and approved or marked with approval numbers by the ethics committee was in a upward trend,the difference was statistically significant in trend test (Z =5.74,5.44,P ＜ 0.01);and the papers were increased from 0.7％ (1/135),0 (0/135) in 2013 to 21.4％ (37/173),11.0％ (19/173) in 2016,compared among different years,the differences were statistically significant (x2 =32.90,29.55,P ＜ 0.01).④The total number of papers published with informed consent or signed was in a upward trend,the difference was statistically significant in trend test (Z =2.56,2.14,P ＜ 0.05);and the papers were increased from 15.6％ (21/135),4.4％ (6/135) in 2013 to 26.6％ (46/173),11.0％(19/173) in 2016,compared among different years,the differences were statistically significant (x2 =6.54,4.60,P ＜ 0.05).Conclusions Medical ethical review is more and more widely used in scientific research and prevention and control of endemic diseases;scientific research workers attach great importance to the ethics review of research projects.However,there are still omissions and missing reports in some projects and articles.The editorial department and editors need to guide the author to raise the author's understanding of the importance of ethical review.