Research progress of the relation of HFA and oarian cancer / 国际肿瘤学杂志

Human epididymis gene product 4 (HFA)mRNA highly expressed in oarian cancer tissue and the quantity was associated with the type of the ovarian cancer;The serum HF4 had the same specificity and sensitivity in the early diagnosis of oarian cancer compared with CA125 ,and the HF4 had an advantage over theCA125 in that it was less frequently positive in patients with nonmalignant disease;the combination of HE4 andCA125 yielded higher sensitivity ;The serum tumor marker HFA is an excellent marker for determining responseto treatment and for the detection of early recurrence of disease in patients with epithelial ovarian cancer; HE4 isnot only a serological tumor biomarker but also a target for gene-based therapy of ovarian cancer.