SEBACEOMA : A RARE CASE REPORT CLINICALLY DIAGNOSED AS PLEOMORPHIC ADENOMA.

Sebaceoma is a benign tumour of epidermal appendages with sebaceous differentiation also known as sebaceous epithelioma .We report a case of a 31 year old male presented with an exophytic mass on the posterior side of right ear lobule. Histopathology revealed rippled pattern sebeceoma comprising of cells arranged in sheets, cohesive nests and islands mostly comprising of basaloid cells (>50%)with mature sebocytes interspersed in between. The sebocytes appeared as clear cells , some cells multivacuolated with central indented nuclei. The rippled pattern sebeceoma is a histological variant and is seen predominantly in males in the head, neck and face region.The immunohistochemistry markers Epithelial Membrane Antigen (EMA) was focally positive along with Pan-Cytokeratin being strongly positive and diffuse which were con?rmatory for the disgnosis.

Epithelioma cuniculatum of the sole of the foot mimicking an infection / Epitelioma cuniculatum de la planta del pie simulando una infección

Abstract: Epithelioma cuniculatum is characterized as a slow growing lesion on the sole of the foot. A diagnosis is usually delayed by a low clinical suspicion and misdirection due to its similarity to an infection. This tumor rarely metastasize but a local invasion of adjacent soft tissues is common, requiring ample surgical resection or even amputation in advanced cases. We report a case a 76-year-old patient with a 5-year-old lesion on the sole of the foot, which was originally treated as a wart without improvement while the lesion slowly evolved. The patient was referred to our center with a diagnosis of chronic osteomyelitis. An excisional biopsy revealed an invasive keratinizing squamous carcinoma. In this advanced phase of the disease the only possible treatment was a Syme amputation.

Resumen: El epitelioma cuniculatum se caracteriza por una lesión de crecimiento lento en la planta del pie cuyo diagnóstico suele retrasarse por la baja sospecha clínica y por su similitud con una infección. Este tumor raramente metastatiza, pero es común que produzca una invasión local a los tejidos blandos adyacentes, requiriendo una amplia resección quirúrgica o incluso una amputación en casos avanzados. Presentamos un caso de un paciente de 76 años con una lesión de 5 años de edad en la planta del pie, que originalmente fue tratada como una verruga plantar común sin mejoría, mientras que la lesión evolucionó lentamente. El paciente fue remitido a nuestro centro con un diagnóstico de osteomielitis crónica. Una biopsia excisional reveló un carcinoma escamoso queratinizante invasivo. En esta fase avanzada de la enfermedad el único tratamiento posible fue una amputación de Syme.

Maxillofacial connective tissue hyperplastic trichoepithelioma: report of two cases and a literature review / 口腔疾病防治

Objective@# To investigate the diagnosis and clinical treatment of maxillofacial connective tissue hyperplastic trichoepithelioma. @*Methods@# The clinical data of two cases of maxillofacial connective tissue hyperplastic trichoepithelioma were summarized and analyzed along with the literature@*Results @# Two cases of maxillofacial connective tissue hyperplastic trichoepithelioma were male, aged 21 and 30 years. The clinical manifestations were painless pale brown and pale white plaques in the maxillofacial region. The lesion was tough and clear, with no ulcers in the middle depression. The course was 10-16 months, with 1-3 months before medical treatment, and the tumor had a significant history of enlargement. After surgery, the skin was cut 3 mm along the outer circumference of the tumor, and local tissue defects were repaired by the adjacent flap. The pathological report showed that the tumor cells were located in the dermis, and were striped, trabecular or nested. The tiny sac contained fibrous connective tissue proliferation. The tumor cells were amorphous without obvious nuclear division. Immunohistochemical analysis reported bcl-2(-), CK7(-), CK19(-), CD34(+), P63(+), CK56(+), and Ki67(±). The pathological diagnosis was connective tissue proliferative hair epithelial tumor. The patient was followed up for 24 months. There was no recurrence of the tumor, no obvious scarring, and no deformity or dysfunction of the maxillofacial region.@*Conclusion@#Pathological and immunohistochemical examination is the basis for the differential diagnosis of maxillofacial connective tissue hyperplastic trichoepithelioma, and surgical removal of tumors is an effective treatment.

Presentación inusual de epitelioma curriculatum en escolar de 12 años / Unusual presentation of curriculatum epitelioma in a 12 years old schoolchild

Introducción: El carcinoma verrugoso es una variante inusual bien diferenciada del carcinoma epidermoide que tiende a aparecer en adultos de mediana edad o mayores. Se considera una neoplasia maligna de grado bajo con cuatro subtipos principales. Objetivo: Referir la infrecuente presentación del carcinoma verrugoso en un adolescente. Presentación de caso: Escolar masculino de 12 años de edad, de raza mestiza, que acude a Consulta Especializada de Dermatología en el Hospital Clínico Quirúrgico Docente Celia Sánchez Manduley con lesión vegetante localizada en planta de pie derecho; se realizan complementarios, biopsia excisional más injerto y se concluye el caso como epitelioma curriculatum. Conclusiones: A nivel clínico, los carcinomas verrugosos se presentan en forma de tumores exofíticos con una superficie papilomatosa o verrugosa. Se asocian con frecuencia a la infección por el virus del papiloma humano, y puede ser difícil distinguir entre un carcinoma verrugoso y una verruga. Es importante el reconocimiento temprano para guiar un diagnóstico preciso y tratamiento oportuno(AU)

Introduction: Verrucous carcinoma is a well differentiated unusual variant of squamous cell carcinoma that tends to occur in middle-aged or older adults. It is considered a low-grade malignant tumour with four main subtypes. Objective: To explain the uncommon presentation of the verrucous carcinoma in a teenager and the importance of early recognition to guide an accurate diagnosis and a timely treatment. Case presentation: 12 years old, school age male, mixed race who attends to specialized consultation of Dermatology in Celia Sánchez Manduley Surgical Clinical Hospital presenting a vegetating lesion located in the right foot´s sole; there were made complementary blood tests, an excisional biopsy plus graft and the case was finally diagnoses as curriculatum epithelioma. Conclusions: At the clinical level, the verrucous carcinomas are presented in the form of exophytic tumors with a papillomatous or verrucous surface. They are often associated with the human papilloma virus infection, and it may be difficult to distinguish between a verrucous carcinoma and a wart(AU)

Fibroxantoma atípico en un anciano / Atypical fibroxanthoma in an elderly

Se describe el caso clínico de un anciano de 72 años de edad, quien presentaba un tumor cutáneo dorsal maligno, por lo cual fue atendido de forma multidisciplinaria en 2 hospitales de la provincia de Santiago de Cuba. Dado el diagnóstico preoperatorio de epitelioma basocelular de piel se procedió a la extirpación del tumor de forma ambulatoria. El resultado del estudio anatomopatológico no confirmó dicho diagnóstico, pero sí corroboró que se trataba de un fibroxantoma atípico. Con los márgenes quirúrgicos de seguridad amplios se logró la curación del paciente.

The case report of a 72 years old man who presented a dorsal cutaneous neoplasm is described, reason why he was assisted in a multidisciplinary way in 2 hospitals from Santiago de Cuba. Given the preoperative diagnosis of skin basal cell epithelioma the tumor was removed in an ambulatory way. The result of the pathologic study didn't confirm this diagnosis, but it corroborated that it was an atypical fibroxanthoma. With the wide surgical margins of security the patient's cure was achieved.

Pilomatrixoma of the Cheek – A Case Report

@#Pilomatrixoma is an uncommon benign tumour arising from the matrix and inner sheath of a normal hair follicle as well as hair cortex. It is usually presented as a superficial, solitary, firm mass which is asymptomatic and slowly growing. It accounts for about 0.2% of all routine skin specimens and may poses a diagnostic challenge as it may resemble other common benign lesions found in the head and neck region. We report a case of a 33-year old men presented to us with a pilomatrixoma of the right cheek, surgical management and histological findings.

Sebaceomas: a propósito de dos casos / Sebaceomas: report of two cases

Los sebaceomas son tumores infrecuentes que se originan en los anexos sebáceos. Suelen desarrollarse en adultos mayores, más frecuentemente en cabeza y cuello. Su denominación es controversial, presentando características histopatológicas y clínicas similares a otras entidades, que presentan diferenciación sebácea. El pronóstico de esta entidad es bueno, siendo su tratamiento la extirpación quirúrgica. Sin embargo, su relevancia clínica se establece por su asociación frecuente con el síndrome de Muir-Torre, por lo que ante la presencia de esta neoplasia, es necesario descartar neoplasias viscerales ocultas. Presentamos el caso de dos pacientes con sebaceomas en diferentes localizaciones, que hasta el momento de esta publicación no presentaron síndrome de Muir-Torre asociado y realizamos una revisión de la literatura.

Sebaceomas are infrequent tumors originated from the sebaceous annexes. They usually develop in the third decade, more frequently in the head and neck. Its denomination is controversial, presenting both histopathological and clinical characteristics similar to other entities, with sebaceous differentiation. The prognosis of the condition is good, being its treatment the surgical removal. Though, its clinical relevance is established by its frequent association with the Muir-Torre syndrome, so that, in the presence of this neoplasm, it is necessary to rule out occult visceral neoplasms. We present two cases of sebaceomas in different locations that until this moment did not present associated neoplasm.

Excision combined with concavity-convex amniotic membrane transplantation in the treatment of intraepithelial epithelioma / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM: To observe the curative effect of excision combined with concavity-convex amniotic membrane transplantation in the treatment of intraepithelial epithelioma.<p>METHODS:Totally 24 cases of intraepithelial neoplasia(24 eye)diagnosed in our department were studied. The tumors of 12 cases were removed and the wound were covered by the concavity-convex amniotic membrane in the conjunctiva and part of the resection, and other 12 were covered by the amniotic membrane. The effect of these two surgeries were assessed via observing the epithelial healing, degradation of biological amnion, tear break-up time, tumor recurrence and other complications. The resection of the tumor were analyzed histopathologically.<p>RESULTS: The pathological results of all the patients were epithelial carcinoma. There were 24 patients that diagnosed -intraepithelial epithelioma pathologically. The conjunctival epithelium healed rapidly and were completed in 5d after operation in both groups. The amniotic membrane was completely degraded in about 14d. Postoperative visual acuity improvement was not statistically significant in two groups. All patients were followed up for more than 1y. The recurrence rates were significantly lower in concavity-convex amniotic membrane group than that in amniotic membrane group. <p>CONCLUSION: Tumor resection combined with concavity-convex amniotic membrane transplantation is an effective operation method for the treatment of intraepithelial epithelioma.

Clinical and pathological analysis of periorbital pilomatricoma in 46 children / 眼科新进展

Objective To analyze the clinical and pathological features of chil dren's periorbital pilomatricoma.Methods The clinical and pathological data of 46 children patients who were diagnosed as periorbital pilomatricoma and underwent surgical treatment between February 2012 and February 2017 were analyzed.Results Of the 46 patients,18 males and 28 females (male:female =l.00:1.56),lesion location of superciliary arch was observed in 26 patients (56.5％),upper eyelid was in 18 patients(39.1％),and the lower eyelid in 2 patients(4.3％).Light microscope was used for pathological examination and the results showed that pilomatricoma was composed of two major cells,and they were basaloid cells and shadow cells.There were 36 patients presenting calcification,25 patients with inflammatory cell infiltration,and 24 patients with multinucleated giant cells.Furthermore,no recurrence or malignant transformation occurred in these patients after surgery.Conclusion Pilomatrixoma presents typical clinical and pathological feature,and it is not uncommon for children patients with periorbital pilomatricoma,so the clinical characteristics of the pilomatricoma and differential diagnosis of the periorbital tumors is important to improve the diagnostic accuracy.

Clinical and pathological analysis of periorbital pilomatricoma in 46 children / 眼科新进展

Objective To analyze the clinical and pathological features of chil dren's periorbital pilomatricoma.Methods The clinical and pathological data of 46 children patients who were diagnosed as periorbital pilomatricoma and underwent surgical treatment between February 2012 and February 2017 were analyzed.Results Of the 46 patients,18 males and 28 females (male:female =l.00:1.56),lesion location of superciliary arch was observed in 26 patients (56.5％),upper eyelid was in 18 patients(39.1％),and the lower eyelid in 2 patients(4.3％).Light microscope was used for pathological examination and the results showed that pilomatricoma was composed of two major cells,and they were basaloid cells and shadow cells.There were 36 patients presenting calcification,25 patients with inflammatory cell infiltration,and 24 patients with multinucleated giant cells.Furthermore,no recurrence or malignant transformation occurred in these patients after surgery.Conclusion Pilomatrixoma presents typical clinical and pathological feature,and it is not uncommon for children patients with periorbital pilomatricoma,so the clinical characteristics of the pilomatricoma and differential diagnosis of the periorbital tumors is important to improve the diagnostic accuracy.

A Case of Eyelid Sebaceoma Mimicking Chalazion

PURPOSE: To report a rare case of sebaceoma misdiagnosed as chalazion. CASE SUMMARY: A 42-year-old female presented with a visible mass in her right lower eyelid. An elevated, hard mass was located at the margin of the right lower eyelid, and she had a history of incision and curettage under the clinical impression of chalazion. On eversion of the lower eyelid, the tarsal portion of the mass was visible as a white-yellowish lesion. The mass was excised under local anesthesia. A sebaceoma was diagnosed based on histopathological examinations. Immunohistochemical studies showed positive staining results for mutator L homologue 1 (MLH1), mutator S homologue 2 (MSH2), and mutator S homologue 6 (MSH6), and she had no past medical history or family history of internal malignancy, suggesting a low possibility of Muir-Torre syndrome. CONCLUSIONS: Eyelid sebaceoma should be considered as a differential diagnosis for refractory chalazion.

A Case of Sebaceoma on the Right Earlobe / 대한피부과학회지

Sebaceoma, also known as sebaceous epithelioma, is a rare, benign, adnexal tumor with sebaceous differentiation. It usually appears as a yellowish papule, nodule, or plaque on the scalp and face, on which there are abundant sebaceous glands. Histologically, it is a well-circumscribed lesion composed of undifferentiated basaloid cells and mature sebaceous cells in relatively preserved lobulated architectures. A 31-year-old woman presented with a 1.3-cm ×1.1-cm nodule on the right earlobe. Mohs micrographic surgery was performed to completely remove it. Histopathological examination revealed that mature sebaceous cells with scalloped nuclei and focal cystic change were present in the lobule.

Reconstrução de dorso nasal: relato de caso / Reconstruction of the nasal dorsum: a case report

INTRODUÇÃO: O dorso nasal é um local comum para o desenvolvimento de neoplasias cutâneas, predominantemente o epitelioma basocelular. Em 1964, Barsky preconiza um retalho quadrangular do dorso nasal, com base na região glabelar, utilizando somente pele da região dorsal. Baseava-se em um procedimento simples recobrindo áreas cruentas até a ponta nasal, resultando em cicatrizes pouco perceptíveis. RELATO DE CASO: Paciente de 82 anos procurou o Serviço de Cirurgia Plástica do Hospital Universitário Maria Aparecida Pedrossian apresentando lesão em dorso nasal de aproximadamente 3 × 2 cm, ulcerada com base eritematosa e limites mal definidos. A técnica utilizada para correção da perda de substância foi o deslizamento de um retalho frontoglabelar com pedículo randomizado. A paciente evoluiu com viabilidade do retalho, apresentando restauração do dorso nasal e resultado estético satisfatório. CONCLUSÃO: Em decorrência da cor e textura adequadas da pele desta região, o retalho frontoglabelar é reconhecidamente uma excelente área doadora para cobertura do dorso do nariz.

INTRODUCTION: The nasal dorsum is a common location for the development of cutaneous tumors, predominantly basal cell epithelioma. In 1964, Barsky recommended a quadrangular flap for coverage of the nasal dorsum, taken from the glabellar region, to most closely match the skin of the dorsal region. This was based on a simple procedure for covering raw areas up to the nasal tip, resulting in less noticeable scars. CASE REPORT: An 82-year-old woman presented to the Plastic Surgery Service of the University Hospital Maria Aparecida Pedrossian with a lesion on the nasal dorsum of approximately 3 x 2 cm, ulcerated with an erythematous base, and ill-defined limits. A fronto-glabellar sliding flap was used to correct the loss of substance. The patient progressed with flap viability, restoration of the nasal dorsum, and satisfactory esthetic results. CONCLUSION: Owing to the color and texture of the skin from this region, the fronto-glabellar flap is an excellent donor area for coverage of the nasal dorsum.

Colgajo bilobulado en epiteliomas basocelulares nasales / Repair of nasal defects secondary to excision of basal-cell epitheliomas

Background: The repair of defects secondary to excision of basal-cell epitheliomas can be a challenge. Aim: To report the experience with the repair of nasal defects using bilobed flaps. Material and Methods: Review of medical records of 10 patients in whom a basal-cell epithelioma was excised and the nasal defect was repaired using a bilobed flap. Results: In all patients, the flap allowed the repair of the defect using the own patient nasal skin, without complications. Conclusions: The bilobed flap is an excellent technique for the repair of medium size nasal defects secondary to excision of basal-cell epitheliomas.

Objetivo: La nariz es el área corporal con mayor incidencia de epiteliomas basocelulares y la reparación de los defectos secundarios a su resección, puede ser un desafío. El objetivo es presentar nuestra experiencia en la reparación de defectos nasales, empleando colgajos bilobulados. Material y Método: Se realizó una revisión retrospectiva de 10 pacientes con epiteliomas basocelulares nasales en que empleamos este colgajo. Resultados: En todos los pacientes el colgajo bilobulado permitió la reparación del defecto, con la propia piel nasal y sin complicaciones. Conclusiones: Consideramos al colgajo bilobulado como una excelente técnica para la reparación de defectos nasales de mediano tamaño, secundarios a la resección de epiteliomas basocelulares.

Reconstrucción palpebral inferior después de la escisión de tumores malignos / Lower eyelid reconstruction after excision of malignancies

Se presentan 4 casos clínicos de pacientes de 46-76 años con carcinomas basocelular y escamoso de párpado inferior, diagnosticados en la consulta oftalmológica del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso". A los afectados se le realizó tarsectomía parcial o total con reconstrucción palpebral mediante colgajos miocutáneos en islas de área cigomática y músculo nasal. Los resultados tanto funcionales como estéticos fueron óptimos y se corroboró la efectividad de los colgajos antes citados.

Four case reports of patients of 46-76 years with squamous-cell carcinoma and basal-cell epithelioma of lower eyelid was described, diagnosed in the ophthalmology department of "Dr. Juan Bruno Zayas Alfonso" Teaching General Hospital. In those affected a partial or total tarsectomy with eyelid reconstruction by means of island myocutaneous flaps of zygomatic area and nasal muscle was performed. The functional and aesthetic results were optimal and the effectiveness of these flaps was confirmed.

Caracterización clinicoepidemiológica de pacientes con tumores palpebrales malignos / Clinical and epidemiological characterization of patients with malignant eyelid tumors

Se efectuó un estudio observacional, descriptivo y transversal de 61 pacientes con tumores palpebrales malignos, atendidos en la consulta de Oftalmología del Instituto Nacional de Oncología y Radiobiología de Ciudad de La Habana, durante el 2011, a fin de caracterizarles según variables clinicoepidemiológicas de interés para la investigación. En la serie, los más afectados fueron el sexo masculino (68,6 por ciento) y los pacientes de piel blanca (86,9 por ciento); predominaron el grupo etario de 61-70 años (37,0 por ciento), el carcinoma basocelular como el tumor palpebral maligno más frecuente (73,8 por ciento) y la agricultura como la labor fundamental que realizaban los enfermos (67,2 por ciento)

An observational, descriptive and cross-sectional study was conducted in 61 patients with malignant eyelid tumors, treated at the Ophthalmology Department of the National Institute of Oncology and Radiobiology, Havana, during 2011, in order to characterize them according to clinical and epidemiological variates of interest to research. Male sex (68.6 percent) and white patients (86.9 percent) were the most affected in the series. Also, the age group of 61-70 years (37.0 percent), basal cell epithelioma as the most frequent malignant eyelid tumor (73.8 percent) and agriculture as the essential work performed by patients (67.2 percent) prevailed

A Giant Sebaceous Epithelioma on the Scalp: A Case Report

PURPOSE: Sebaceous epithelioma (sebaceoma) is a benign tumor with sebaceous differentiation. It presents primarily as a yellowish papule or nodule on the face and scalp. It must be differentiated from basal cell carcinoma and other appendageal tumors. We report a giant sebaceous epithelioma on the scalp and describe the immunohistochemical character of the cells in sebaceous epithelioma to epithelial membrane antigen (EMA). METHODS: A 55-year-old-man who presented with 5-cm-diameter 2-cm-height, round shape exophytic ulcerated tumor on his head presented for treatment. The patient had noticed the lesion 40 years prior as a small yellowish plaque and 18 months ago, the plaque started to grow progressively larger. We excised the lesion with 1 cm resection margin, considering the possibility of malignancy because this lesion grossly resembled basal cell carcinoma (BCC). The defect was repaired with the use of a split-thickness skin graft. RESULTS: When we excised the lesion, the margin was clear. Histology showed nodules that consisted of an admixture of basaloid cells and mature adipocytes lacking an organized lobular architecture. Strong expression of EMA on mature adipose cells confirmed the differential diagnosis from BCC with sebaceous differentiation because of the absence of a nuclear palisade pattern and cleft-like spaces on the hematoxylin and eosin (H&E) section. CONCLUSION: We treated the giant sebaceous epithelioma on the scalp with surgical excision and a split-thickness skin graft. It is important to know that the diagnosis of sebaceous epithelioma should be made based on the histologic pattern of the H&E section. Immunohistochemistry with EMA can help to confirm the differential diagnosis between sebaceous epithelioma and BCC.

A Giant Sebaceous Epithelioma on the Scalp: A Case Report

PURPOSE: Sebaceous epithelioma (sebaceoma) is a benign tumor with sebaceous differentiation. It presents primarily as a yellowish papule or nodule on the face and scalp. It must be differentiated from basal cell carcinoma and other appendageal tumors. We report a giant sebaceous epithelioma on the scalp and describe the immunohistochemical character of the cells in sebaceous epithelioma to epithelial membrane antigen (EMA). METHODS: A 55-year-old-man who presented with 5-cm-diameter 2-cm-height, round shape exophytic ulcerated tumor on his head presented for treatment. The patient had noticed the lesion 40 years prior as a small yellowish plaque and 18 months ago, the plaque started to grow progressively larger. We excised the lesion with 1 cm resection margin, considering the possibility of malignancy because this lesion grossly resembled basal cell carcinoma (BCC). The defect was repaired with the use of a split-thickness skin graft. RESULTS: When we excised the lesion, the margin was clear. Histology showed nodules that consisted of an admixture of basaloid cells and mature adipocytes lacking an organized lobular architecture. Strong expression of EMA on mature adipose cells confirmed the differential diagnosis from BCC with sebaceous differentiation because of the absence of a nuclear palisade pattern and cleft-like spaces on the hematoxylin and eosin (H&E) section. CONCLUSION: We treated the giant sebaceous epithelioma on the scalp with surgical excision and a split-thickness skin graft. It is important to know that the diagnosis of sebaceous epithelioma should be made based on the histologic pattern of the H&E section. Immunohistochemistry with EMA can help to confirm the differential diagnosis between sebaceous epithelioma and BCC.

A Case of Superficial Epithelioma with Sebaceous Differentiation / 대한피부과학회지

No abstract available.

Clinical features and micro-invasive reshaping repair of calcified epithelioma in head and face / 中华医学美学美容杂志

Objective Calcified epithelioma is a rare benign tumor in head and face. It is seldomly seen canceration. But it has local invasion behavior. The aim of this study was to explore the methodology in the diagnosis and treatment of calcified epithelioma in head and face, and to improve the accuracy of clinical diagnosis. Methods A retrospective analysis was carried out in 26 patients with calcified epithelioma in head and face. Results 53. 8 % patients with calcified epithelioma were less than 13-year-old. The disease was easily misdiagnozed. In this group of patients the misdiagnosis rate reached to 42. 3 %. Btype ultrasonographic diagnosis possessed a high level of concordance with histological diagnosis. There were three major types of calcified epithelioma: type 1, a mass with internal echoic foci; type 2, a hyperechoic mass with high beam; type 3, no calcification in the parenchyma. Piomatricoma was described as a skin tumour histologically composed of shadowcells, basophillic cells, foreign body giant cells and intracellular and stromal calcification. The treatment was excision and no recurrences were found by followup. Conclusions It is important for clinicians to know the clinical features of calcified epithelioma. Imaging studies including ultrasonography would help establish the diagnosis. Surgical excision with clear margins is recommended for this tumor.