Role of Esophageal Sensory Receptor Pathways in Development of Esophageal Hypersensitivity / 胃肠病学

Gastroesophageal reflux disease (GERD) is a common digestive disease characterized by heartburn and acid reflux. In recent years, many studies have shown that esophageal hypersensitivity is an important pathophysiological mechanism involved in the occurrence and development of heartburn. Esophageal sensory receptors including transient receptor potential vanilloid 1 (TRPV1), prostaglandin E

Relationship between esophageal visceral hyperesthesia and expression of substance P in LES of patients with non-erosive gastro-oesophageal reflux disease / 解放军医学杂志

Objective To investigate the correlations between esophageal visceral hyperesthesia and the expression of substance P (SP) immunoreactive fibers in the lower esophageal sphincter (LES). Methods Esophageal sensitivity to mechanical stimuli was measured by esophageal barostat. The Bernstein acid infusion test was used to evaluate the esophageal sensitivity to intraesophageal perfusion of 0.1mol/L HCl .The distribution and expression of SP positive fibers within mucosal layer of LES were detected by immonohistochemical staining techniques. Results In comparison with control group, the initial perception threshold and maximally tolerated pain threshold of NERD patients were significantly reduced (P