RESUMEN
Background: Essential hypertension (EHTN) is emerging as one of the most prevalent disorder with highrate of complications, morbidity and mortality. Brahmi vati, an Ayurvedic medicine is explored for itsefficacy in the management of EHTN.Objective: To evaluate the efficacy of Brahmi vati and sarpagandha Ghana vati in the management ofEHTN.Methods: Total 68 patients meeting the JNC 7 criteria of EHTN of age group 20 to 60 years of either sexparticipated in the study. They were randomly divided into two groups, group A received capsule Brahmi vati500 mg and group B capsule Sarpagandha Ghana vati 500 mg respectively twice a day for 30 days. Assessmentswere done through various variables like systolic blood pressure (SBP), diastolic blood pressure (DBP), meanarterial pressure (MAP), lipid profiles, Hamilton anxiety rating scale, 2 weeks sleep diary, serum creatinine,hemoglobin, total leukocyte count and erythrocyte sedimentation rate. Follow up visit was on every 15th day.Results: Study showed that both Brahmi vati and Sarpagandha Ghana vati produced improvement in mostof the variables and were comparable. Improvements were seen in various variables like SBP, DBP, MAP,Hamilton anxiety rating scale, subjective sleep profiles and total cholesterol. However Brahmi vatishowed increase in weight and Body Mass Index (BMI). Sarpagandha Ghana vati produced reduction intotal cholesterol and LDL. Both groups showed good safety profile evaluated through the assessment ofserum creatinine levels.Conclusion: Clinical efficacy of Sarpagandha Ghana vati and Brahmi vati on EHTN showed that both wereeffective, safe and comparable.© 2017 The Authors. Published by Elsevier B.V. on behalf of Institute of Transdisciplinary Health Sciencesand Technology and World Ayurveda Foundation. This is an open access article under the CC BY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).