Questionário de adaptação ao ensino superior remoto: ampliação das propriedades psicométricas / Adaptation to remote higher education questionnaire: expansion of psychometric properties / Cuestionario de adaptación para educación superior remota: expansión de propiedades psicométricas

Objetivou-se investigar as evidências de validade baseadas na relação com outras variáveis do Questionário de Adaptação ao Ensino Superior Remoto (QAES-R). Foram analisadas as relações entre o QAES-R com os motivos para evasão acadêmica e a motivação. Participaram 319 universitários das cinco regiões do Brasil (M idade = 26,25; DP = 9,5). Identificaram-se correlações estatisticamente significativas entre o QAES-R e a maior parte dos fatores dos demais instrumentos. No primeiro modelo testado, os fatores do QAES-R foram preditores da evasão acadêmica Social (32%), Acadêmico (24%), Institucional (15%) e Professor (10%) (χ 2 /gl = 1,87; RMSEA = 0,05; CFI = 0,87; TLI = 0,87). No segundo modelo, o QAES-R predisse a meta aprender (45%), performance- evitação (39%) e performance-aproximação (30%) (χ 2 /gl = 1,42; RMSEA = 0,04; CFI = 0,90; TLI = 0,90). Estes resultados ampliam as propriedades psicométricas do QAES-R para avaliar a adaptação acadêmica de estudantes submetidos ao ensino remoto emergencial. (AU)

The objective was to investigate the validity evidence of the relationship between the Questionnaire for Adaptation to Remote Higher Education (QAES-R) and other variables. The study analyzed the relationships between the QAES-R with the reasons for academic dropout and motivation. A total of 319 Brazilian university students participated (Mage = 26.25; SD = 9.5). Statistically significant correlations were identified between the QAES-R and most factors of the other instruments. In the first model tested, the QAES-R factors predicted academic dropout : Social (32%), Academic (24%), Institutional (15%), and Teacher (10%) (χ 2 /gl = 1.87; RMSEA = .05; CFI = .87; TLI = .87). In the second model, the QAES-R predicted learning goals (45%), performance-avoidance (39%), and performance-approach (30%) (χ 2 /gl = 1.42; RMSEA = .04; CFI = .90; TLI = .90). These results extend the psychometric properties of the QAES-R to assess the academic adaptation of students during emergency remote teaching. (AU)

El objetivo fue investigar las evidencias de validez basadas en la relación con otras variables del Cuestionario de Adaptación a Educación Superior Remota (QAES-R). Se analizaron las relaciones entre el QAES-R con los motivos de abandono académico y la motivación. Participaron 319 estudiantes universitarios brasileños de las 5 regiones de Brasil (M edad = 26,25; DS = 9,5). Se identificaron correlaciones estadísticamente significativas entre el QAES-R y la mayoría de los factores de los otros instrumentos. En el primer modelo, los factores del QAES-R fueron predictores del abandono académico Social (32%), Académico (24%), Institucional (15%) y Docente (10%) (χ 2 /gl = 1.87; RMSEA = 0.05; CFI = 0.87; TLI = 0.87). En el segundo modelo, el QAES-R predijo la meta de aprender (45%), la evitación del desempeño (39%) y el enfoque de desempeño (30%) (χ 2 /gl = 1.42; RMSEA = 0.04; CFI = 0 .90; TLI = 0.90). Estos resultados amplían las propiedades psicométricas del QAES-R. (AU)

Tax rules on wealth imbalance and the investigation of money laundering in Peru / Las reglas tributarias sobre desbalances patrimoniales y la investigación del lavado de activos: el caso peruano / Regras tributárias sobre desproporções patrimoniais e investigação de lavagem de dinheiro: o caso peruano

This study aims to evaluate the feasibility of using the tax methodology for determining unjustified increases in assets in money laundering cases heard in the courts. It also seeks to identify the errors made by the Tax Authority with the purpose of ascertaining whether these errors could hinder the successful application of the methodology in investigations of money laundering cases. In order to achieve these objectives, a mixed research methodology was conducted that included the analysis of rulings issued during the years 2020 and 2021 by the Peruvian Tax Court and sentences issued by the judiciary. This was complemented by semi-structured interviews with experts from the public sector, academia and accounting with relevant experience on the subject. The study found that there are some practical issues in the application of the methodology that can be overcome and that do not represent an insurmountable constraint. The study also found that the tax methodology allows for a more effective clarification of asset imbalances, and concludes that, once implementation errors have been overcome, the tax methodology can be feasibly employed to the benefit of money laundering investigations.

Esta investigación tiene como objetivos evaluar la factibilidad de utilizar la metodología tributaria de determinación de incrementos patrimoniales no justificados en la investigación de desbalances patrimoniales de casos de lavado de dinero ventilados en la vía jurisdiccional e identificar los errores que ha cometido la Administración Tributaria, a fin de establecer si estos representan problemas que pudieran dificultar la aplicación de la metodología a la investigación de casos de lavado de dinero. Con el propósito de lograr estos objetivos se condujo una investigación mixta que incluyó el análisis de las resoluciones emitidas durante los años 2020 y 2021 por el Tribunal Fiscal y sentencias emitidas por el poder judicial. Esto se complementó con entrevistas semiestructuradas a expertos del sector público, la academia y peritos contables con experiencia relevante sobre el tema. La investigación encontró que existen algunos empirismos aplicativos que pueden ser superados y que no representan ninguna restricción que no pueda ser gestionada. Se halló también que la metodología tributaria permite esclarecer de manera más efectiva los desbalances patrimoniales. La investigación concluye que, superados los errores de ejecución, es factible utilizar con ventaja la metodología tributaria en las investigaciones de lavado de dinero.

O objetivo desta pesquisa é avaliar a viabilidade do uso da metodología tributária para determinar aumentos injustificados de patrimônio na investigação de desproporções patrimoniais em casos de lavagem de dinheiro julgados nos tribunais e identificar os erros cometidos pela Administração Tributária, a fim de estabelecer se estes representam problemas que poderiam dificultar a aplicação da metodologia na investigação de casos de lavagem de dinheiro. Para atingir esses objetivos, foi realizada uma pesquisa mista que incluiu a análise de decisões emitidas durante 2020 e 2021 pelo Tribunal Tributário e sentenças emitidas pelo judiciário. Isso foi complementado por entrevistas semiestruturadas com especialistas do setor público, acadêmicos e especialistas em contabilidade com experiência relevante no assunto. A pesquisa constatou que existem alguns empirismos de aplicação que podem ser superados e que não representam nenhuma restrição que não possa ser gerenciada. Também foi constatado que a metodología tributária permite um esclarecimento mais eficaz das desproporções patrimoniais. Na pesquisa, conclui-se que, uma vez superados os erros de implementação, é viável utilizar a metodologia tributária com vantagem nas investigações de lavagem de dinheiro.

Discussion on the mechanism of Yanghe Decoction in treating chronic osteomyelitis based on network pharmacology and molecular docking / 国际中医中药杂志

Objective:To study the active components and their potential mechanism of Yanghe Decoction for the treatment of chronic osteomyelitis (CO) via the methods of network pharmacology and molecular docking.Methods:Active components and action targets of Yanghe Decoction were screened from TCMSP, BATMAN-TCM and relevant literature. GeneCards, OMIM, DisGeNET, and PharmGKB databases were used to predict the targets for the CO. Cytoscape 3.8.0 software and STRING database were used to build the networks of "Chinese materia medica-active components-potential targets" and "protein-protein interaction", and according to topological parameters in the network, the core active components as well as Hub genes were screened. MCODE plug was used to accomplish clustering analysis of protein modules in PPI network. Then, intersection targets were enriched and analyzed by GO and KEGG in KOBAS database. Finally, molecular docking was carried out with the help of Autodock tool platform to predict the binding ability between the main active components and key targets.Results:A total of 120 active components of Yanghe Decoction and 402 targets were obtained; 1 464 CO-related targets were screened, and there were 103 intersection target genes of Yanghe Decoction-CO, 110 active components related to intersection targets, which mainly contained some flavonoids and Phytosterols, such as quercetin, Kaempferol, and Beta-Sitosterol. There were 9 Hub genes, including TNF, IL6, AKT1, etc., and 4 protein modules which involved the regulation of immune inflammatory response, vascular microcirculation, bone development, and formation, material synthesis and metabolism and other physiological processes. 193 signaling pathways and 1 552 GO results were acquired in KOBAS database. Molecular docking results showed that the active compounds had good binding activity with key targets based on the minimum binding energy of less than - 5 kcal/mol.Conclusion:The mechanism in the treatment of CO with Yanghe Decoction is a complex process of multiple components, multiple targets, and multiple pathways. It mainly regulates targets such as TNF, IL-6, CXCL8, VEGFA, and AKT1 through pathways such as TNF signaling pathway, IL-17 signaling pathway, and Toll-like receptors, participating in local inflammatory reactions, microcirculation, and bone cell metabolism in chronic osteomyelitis, and interfering with the immune escape mechanism of pathogenic bacteria.

The action mechanism of glioblastoma cell-derived exosome: a review / 生物工程学报

Patients with glioblastoma (GBM) generally have a bad prognosis and short overall survival after being treated with surgery, chemotherapy or radiotherapy due to the histological heterogeneity, strong invasive ability and rapid postoperative recurrence of GBM. The components of GBM cell-derived exosome (GBM-exo) can regulate the proliferation and migration of GBM cell via cytokines, miRNAs, DNA molecules and proteins, promote the angiogenesis via angiogenic proteins and non-coding RNAs, mediate tumor immune evasion by targeting immune checkpoints with regulatory factors, proteins and drugs, and reduce drug resistance of GBM cells through non-coding RNAs. GBM-exo is expected to be an important target for the personalized treatment of GBM and a marker for diagnosis and prognosis of this kind of disease. This review summarizes the preparation methods, biological characteristics, functions and molecular mechanisms of GBM-exo on cell proliferation, angiogenesis, immune evasion and drug resistance of GBM to facilitate developing new strategies for the diagnosis and treatment of GBM.

Research progress of interaction between peste des petits ruminants virus and host cells / 中国生物制品学杂志

@#Peste des petits ruminants(PPR)is a highly contagious disease with high mortality which is caused by peste des petits ruminants virus(PPRV)infection and leads to enormous economic losses for sheep husbandry both at home and abroad. The knowledge of interactions between PPRV and host cells is the basis of understanding of the pathogenesis and the prerequisite of disease prevention and control. This paper reviews the studies on the activation of host innate immune response by PPRV infection,the immune evasion of PPRV mediated by viral protein products,and the induction of apoptosis,autophagy and inflammasome resistance to virus,which provides a reference for further discussion on the immune evasion of PPRV and the key nodes involved in the interaction between PPRV and the host,thus providing theoretical guidance for effective prevention and control of PPR transmission.

Exploration of Immune Tolerance and Treatment for Esophageal Cancer / 肿瘤防治研究

Monoclonal antibody drugs that inhibit programmed death 1 (PD-1) or programmed death ligand 1 (PD-L1) have been widely used in esophageal cancer (EC) and yielded significant therapeutic responses. However, only a few patients obtain lasting clinical benefits due to primary or acquired drug resistance, and new treatment schemes are urgently needed. The tumor immune microenvironment is the main factor that affects patients' response to immunosuppressive agents. This article will discuss the role of immunosuppressive cells and non-cellular components in the immune process to provide ideas for the next research direction of EC.

Evasão no ensino superior: análise sistemática da literatura entre 2010 e 2019 / Dropouts in higher education: systematic analysis of literature between 2010 and 2019 / Evasión en educación superior: análisis sistemático de la literatura entre 2010 y 2019

A evasão universitária é um fenômeno complexo, que se caracteriza pela decisão ativa do abandonar o curso. Este estudo teve como objetivo revisar a literatura científica (método PRISMA) acerca da evasão universitária dos últimos dez anos (2010 e 2019) no Portal dos Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Dos 18 artigos analisados, as maiores frequências foram de estudos transversais, publicados entre 2016 e 2019, em periódicos das áreas de Psicologia e da Educação. Maiores frequências de investigações com discentes nos cursos da área "Negócios, administração e direito" e de instituições públicas. Os construtos associados à evasão foram vivências acadêmicas, adaptabilidade de carreira, satisfação com a instituição e autoeficácia na formação superior. Questionários sem estudos psicométricos anteriores foram os instrumentos mais utilizados para mensurar motivos para evasão. Outras discussões e recomendações são apresentadas no decorrer do artigo

University dropout is a complex phenomenon, characterized by the student's active decision to drop out of the course. This study aimed to review the scientific literature (PRISMA method) about university dropouts in the last ten years (2010 and 2019) in the Journal Portal of the Coordination for the Impro-vement of Higher Education Personnel. Of the 18 articles analyzed, the highest frequencies were cross-sectional studies, published between 2016 and 2019, in journals in the fields of Psychology and Education. Higher frequency of investigations with students in courses in the area "Business, administration and law" and in public institutions. The constructs associated with dropout were academic experiences, career adaptability, satisfaction with the institution and self-efficacy in higher education. Questionnaires without previous psychometric studies were the instruments most used to measure reasons for dropout. Other discussions and recommendations are presented throughout the article

La deserción universitaria es un fenómeno complejo, caracterizado por la decisión activa del alumno de abandonar la asignatura. Este estudio tuvo como objetivo revisar la literatura científica (método PRISMA) sobre la deserción universitaria en los últimos diez años (2010 y 2019) en el Portal de Revistas de la Coordinación para la Perfeccionamiento del Personal de Educación Superior. De los 18 artículos analizados, las frecuencias más altas fueron estudios transversales, publicados entre 2016 y 2019, en revistas del ámbito de la Psicología y la Educación. Mayor frecuencia de investigaciones con estudiantes en cursos del área "Negocios, administración y derecho" y en instituciones públicas. Los constructos asociados a la deserción fueron experiencias académicas, adaptabilidad a la carrera, satisfacción con la institución y autoeficacia en la educación superior. Los cuestionarios sin estudios psicométricos previos fueron los instrumentos más utilizados para medir los motivos de abandono. Otras discusiones y recomendaciones se presentan a lo largo del artículo

Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report

BACKGROUND There is interest in lingering non-specific symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, referred to as Long coronavirus disease 2019 (Long COVID-19). It remains unknown whether the risk of Long COVID-19 is associated with pre-existing comorbidities or initial COVID-19 severity, including infections due to new Omicron lineages which predominated in 2023. OBJECTIVES The aim of this case report was to characterize the clinical features of acute XBB.1.5 infection followed by Long COVID-19. METHODS We followed a 73-year old female resident of Rio de Janeiro with laboratory-confirmed SARS-CoV-2 during acute infection and subsequent months. The SARS-CoV-2 lineage was determined by genome sequencing. FINDINGS The participant denied comorbidities and had completed a two-dose vaccination schedule followed by two booster doses eight months prior to SARS-CoV-2 infection. Primary infection by viral lineage XBB.1.5. was clinically mild, but the participant subsequently reported persistent fatigue. MAIN CONCLUSIONS This case demonstrates that Long COVID-19 may develop even after mild disease due to SARS-CoV-2 in fully vaccinated and boosted individuals without comorbidities. Continued monitoring of new SARS-CoV-2 lineages and associated clinical outcomes is warranted. Measures to prevent infection should continue to be implemented including development of new vaccines and antivirals effective against novel variants.

Identificação de evasão fiscal utilizando dados abertos e inteligência artificial / Identificación de la evasión fiscal mediante datos abiertos e inteligencia artificial / Tax evasion identification using open data and artificial intelligence

Resumo A evasão fiscal é a consequência da prática da sonegação. Apenas no Brasil, estima-se que ela corresponda a 8% do PIB. Com isso, os governos necessitam de sistemas inteligentes para apoiar os auditores fiscais na identificação de sonegadores. Tais sistemas dependem de dados sensíveis dos contribuintes para o reconhecimento dos padrões, que são protegidos por lei. Com isso, o presente trabalho apresenta uma solução inteligente, capaz de identificar os perfis de potenciais sonegadores com o uso apenas de dados abertos, públicos, disponibilizados pela Receita Federal e pelo Conselho Administrativo Tributário do Estado de Goiás, entre outros cadastros públicos. Foram gerados três modelos que utilizaram os recursos Random Forest, Redes Neurais e Grafos. Em validação depois de melhorias finas, foi possível obter acurácia superior a 98% na predição do perfil inadimplente. Por fim, criou-se uma solução de software visual para uso e validação pelos auditores fiscais do estado de Goiás.

Resumen La evasión fiscal es la consecuencia de la práctica de la defraudación tributaria. En Brasil, se estima que corresponde al 8% del PIB. Por lo tanto, los gobiernos necesitan y utilizan sistemas inteligentes para ayudar a los agentes de hacienda a identificar a los defraudadores fiscales. Dichos sistemas se basan en datos confidenciales de los contribuyentes para el reconocimiento de patrones, que están protegidos por ley. Este trabajo presenta una solución inteligente, capaz de identificar perfiles de potenciales defraudadores fiscales, utilizando únicamente datos públicos abiertos, puestos a disposición por la Hacienda Federal y por el Consejo Administrativo Tributario del Estado de Goiás, entre otros registros públicos. Se generaron tres modelos utilizando random forest y neural networks. En la validación después de finas mejoras, fue posible obtener una precisión superior al 98% en la predicción del perfil moroso. Finalmente, se creó una solución de software visual para uso y validación por parte de los auditores fiscales del estado de Goiás.

Abstract Tax evasion is the practice of the non-payment of taxes. In Brazil alone, it is estimated as 8% of GDP. Thus, governments must use intelligent systems to support tax auditors to identify tax evaders. Such systems seek to recognize patterns and rely on sensitive taxpayer data that is protected by law and difficult to access. This research presents a smart solution, capable of identifying the profile of potential tax evaders, using only open and public data, made available by the Brazilian internal revenue service, the administrative council of tax appeals of the State of Goiás, and other public sources. Three models were generated using Random Forest, Neural Networks, and Graphs. The validation after fine improvements offered an accuracy greater than 98% in predicting tax evading companies. Finally, a web-based solution was created to be used and validated by tax auditors of the State of Goiás.

Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy

Cancer immunotherapy is impaired by the intrinsic and adaptive immune resistance. Herein, a bispecific prodrug nanoparticle was engineered for circumventing immune evasion of the tumor cells by targeting multiple immune resistance mechanisms. A disulfide bond-linked bispecific prodrug of NLG919 and JQ1 (namely NJ) was synthesized and self-assembled into a prodrug nanoparticle, which was subsequently coated with a photosensitizer-modified and tumor acidity-activatable diblock copolymer PHP for tumor-specific delivery of NJ. Upon tumor accumulation via passive tumor targeting, the polymeric shell was detached for facilitating intracellular uptake of the bispecific prodrug. NJ was then activated inside the tumor cells for releasing JQ1 and NLG919 via glutathione-mediated cleavage of the disulfide bond. JQ1 is a bromodomain-containing protein 4 inhibitor for abolishing interferon gamma-triggered expression of programmed death ligand 1. In contrast, NLG919 suppresses indoleamine-2,3-dioxygenase 1-mediated tryptophan consumption in the tumor microenvironment, which thus restores robust antitumor immune responses. Photodynamic therapy (PDT) was performed to elicit antitumor immunogenicity by triggering immunogenic cell death of the tumor cells. The combination of PDT and the bispecific prodrug nanoparticle might represent a novel strategy for blockading multiple immune evasion pathways and improving cancer immunotherapy.

Revisão sistemática: critérios de qualidade no projeto de programas de orientação vocacional / Revisión sistemática: criterios de calidad en el proyecto de programas de orientación vocacional / Systematic review: quality criteria in the vocational orientation programs project

La presente investigación exploró el diseño de programas de orientación vocacional para educación formal en el nivel secundario, para resolver la carencia de un programa de orientación vocacional efectivo y adecuado a las condiciones sociodemográficas de la población estudiantil. El objetivo fue desarrollar una síntesis crítica de la literatura científica relacionada a la orientación vocacional y profesional, mediante investigación aplicada a partir de la metodología de revisión sistemática. A partir del análisis, se concluyó que son acciones esenciales en los programas de orientación profesional para determinar altos niveles de calidad: ofrecer información sobre oferta académica y demanda laboral, desarrollar perfiles ocupacionales de las diferentes carreras, ofrecer información sobre intereses, aptitudes y preferencias, realizar entrenamiento en toma de decisiones, vincular al grupo de apoyo primario, proveer estrategias para el desarrollo de la autoeficacia y madurez vocacional, apoyarse en el uso de las TICs, proveer estrategias para la transición, priorizar el rol del orientador y los pares, establecer un proyecto o plan de vida, contar con un fundamento teórico y desarrollar evaluación constante de los programas. Con la intención de reducir la tasa de deserción universitaria y promover el desarrollo humano, se sugiere la aplicación de esos criterios en programas vocacionales desarrollados a largo plazo, durante las distintas etapas del ciclo de vida.

A presente investigação pesquisou a concepção de programas de orientação vocacional para a educação formal no nível secundario, visando resolver a carência de um programa de orientação vocacional efetivo e adequado às condições sociodemográficas da população estudantil. O objetivo foi desenvolver uma síntese crítica da literatura científica relacionada à orientação vocacional e profissional, mediante investigação aplicada a partir da metodologia de revisão sistemática. A partir da análise, concluiu-se que são ações essenciais nos programas de orientação profissional para determinar altos níveis de qualidade: oferecer informação sobre oferta acadêmica e demanda laboral, deenvolver perfis ocupacionais das diferentes carreiras, oferecer informação sobre interesses, aptidões e preferências, realizar treinamento em tomada de decisões, vincular-se ao grupo de apoio principal, prover estratégias para o desenvolvimento da autoeficácia e maturidade vocacional, apoiar-se no uso de TICs, prover estratégias para a transição, priorizar o papel do orientador e dos pares, estabelecer um projeto ou plano de vida, contar com um fundamento teórico e promover avaliação constante dos programas. Com a intenção de reduzir a taxa de evasão universitária e promover o desenvolvimento humano, sugere-se a aplicação desses critérios em programas vocacionais realizados a longo prazo, durante as distintas etapas do ciclo de vida.

The present investigation explores the design of vocational guidance programs for formal education at the secondary level, to address the lack of an effective vocational guidance program suited to the sociodemographic conditions of the student population. The objective was to develop a critical synthesis of the scientific literature related to vocational and professional orientation, through applied research based on the systematic review methodology. From the analysis, it was concluded that there are essential actions in professional orientation programs to determine high levels of quality: to offer information about academic supply and labor demand, to develop occupational profiles of different careers, to offer information on interests, aptitudes and preferences, carry out training in decision making, link to the primary support group, provide strategies for the development of self-efficacy and vocational maturity, support the use of ICTs, provide strategies for the transition, prioritize the role of mentor and peers, establish a project or life plan, counting on a theoretical foundation and developing a constant evaluation of the vocational programs, during the different stages of the life cycle.

Fatores de evasão no ensino superior: uma revisão de literatura / Dropout factors in higher education: a literature review

A evasão no Ensino Superior constitui preocupação internacional com impacto nas Instituições de Ensino Superior, em geral, e nos percursos de carreira individuais, em específico. Para prevenir esse fenômeno e apoiar tanto instituições como estudantes na sua tomada de decisão, urge identificar fatores de evasão no ensino superior. Apresenta-se revisão de artigos publicados em revistas científicas internacionais entre janeiro 2014 e dezembro 2018, com base no Modelo Longitudinal de Evasão Institucional. A pesquisa foi realizada em quatro bases de dados, com combinações das palavras-chave dropout, departure, academic adjustment, college adjustment, academic integration, social integration e higher education. Foram lidos integralmente 24 artigos que satisfaziam critérios de inclusão. Procedeu-se à descrição dos artigos e o conteúdo foi sistematizado em meta-síntese. Identificaram-se fatores relativos a atributos prévios à entrada no ensino superior; objetivos e compromissos prévios e posteriores a essa entrada; experiências institucionais; integração acadêmica e social. Identificaram-se ainda medidas de sinalização de evasão. Discutem-se implicações para a investigação, para serviços e políticas das Instituições de Ensino Superior.

La evasión en lo Enseñanza Universitaria constituye preocupación internacional con impacto en las Instituciones de Enseñanza Universitaria, en general, y en los recorridos de carrera individuales, en específico. Para prevenir ese fenómeno y apoyar tanto instituciones, como estudiantes en su toma de decisión, es urgente identificar factores de evasión en la enseñanza universitaria. Se presenta revisión de artículos publicados en revistas científicas internacionales entre enero 2014 y diciembre 2018, con base en el Modelo Longitudinal de Evasión Institucional. La investigación se realizó en cuatro bases de datos, con combinaciones de las palabras clave dropout, departure, academic adjustment, college adjustment, academic integration, social integration y higher education. Se leyeron integralmente 24 artículos que satisfacían criterios de inclusión. Se procedió a la descripción de los artículos y se sistematizó los contenidos en meta-síntesis. Se identificaron factores relativos a atributos previos al ingreso en la enseñanza universitaria; objetivos y compromisos previos y posteriores a esa entrada; experiencias institucionales; integración académica y social. Se identificaron, aún medidas de señalización de evasión. Se discuten implicaciones para la investigación, para servicios y políticas de las Instituciones de Enseñanza Universitaria.

Dropping out of Higher Education is an international concern with an impact on Higher Education Institutions, in general, and on individual career paths, in particular. In order to prevent this phenomenon and support both institutions and students in their decision-making, it is urgent to identify evasion factors in higher education. A review made in published articles in international scientific journals between January 2014 and December 2018 is presented, based on the Longitudinal Institutional Evasion Model. The search was carried out in four databases, with combinations of the keywords dropout, departure, academic adjustment, college adjustment, academic integration, social integration, and higher education. Twenty-four articles that met the inclusion criteria were fully read. The articles were described and the content was systematized in meta-synthesis. Factors related to attributes prior to entering higher education were identified; objectives and commitments prior and subsequent to this entry; institutional experiences; academic and social integration. Evasion signaling measures were also identified. Implications for research, services and policies of Higher Education Institutions are discussed.

Carcinoma espinocelular avançado e imunoterápicos: novas perspectivas terapêuticas / Advanced squamous cell carcinoma and immunotherapy: new therapeutic perspectives

O carcinoma espinocelular (CEC) apresenta a segunda maior taxa de incidência entre os cânceres de pele não melanoma. Cerca de 5% desses casos evoluem para lesões localmente avançadas e/ou metastáticas, tornando a abordagem cirúrgica muitas vezes inviável. Com base nisso, foi realizada uma revisão na literatura sobre o uso de imunoterápicos no tratamento do CEC avançado. Observou-se, então, que a imunoterapia é uma potencial estratégia terapêutica devido à promoção da atividade antitumoral por meio da própria resposta imunológica individual, o que contribui para a redução dos efeitos colaterais de cirurgias, quimioterapias e radioterapias.

Squamous cell carcinoma (SCC) has the second highest incidence rate among non-melanoma skin cancers. About 5% of cases progress to locally advanced and/or metastatic lesions, making the surgical approach often unfeasible. Based on this, we performed a literature review on the use of immunotherapy drugs to treat advanced SCC. The results showed that immunotherapy is a potential therapeutic strategy due to the antitumor activity promotion through the individual immune response, reducing the adverse events of surgeries, chemotherapy, and radiotherapy

The interaction between 2019-nCoV and interferon Ⅰ / 中华临床感染病杂志

COVID-19 has swept across the world, causing widespread epidemics and millions of life lost worldwide. After infected with 2019-nCoV, the body quickly mobilizes the innate immune response and produces type Ⅰ interferon (IFN-Ⅰ). IFN-Ⅰ plays an important role in virus clearance in the early stage of disease. This article reviews the innate immune recognition after virus infection and the interaction between 2019-nCoV and IFN-Ⅰ, which would be conductive to understanding the pathogenesis and antiviral treatment of COVID-19.

Advances in research on tumor immunotherapy and its drug development / 中国药科大学学报

@#The progress of molecular biology and tumor biology has greatly changed the mode of cancer treatment. A large number of scientific studies have revealed the mechanism of tumor immune evasion, and a variety of new types of tumor immunotherapy have emerged, which has become another effective treatment of cancer after surgery, radiotherapy, chemotherapy and targeted therapy. This paper introduces the mechanism of tumor cell immune evasion, and focuses on the design principle, biological drugs and the latest research progress of immunotherapy, such as cytokine immunotherapies, therapeutic monoclonal antibody immunotherapy, PD-1/PD-L1 therapy, CAR-T therapy, tumor vaccine, oncolytic virus and so on. At the same time, the advantages and disadvantages of various immunotherapies are compared to provide reference for drug research and development in tumor immunotherapy.

Respuesta inmune disfuncional en pacientes con COVID-19. ¿Qué nos dice la evidencia? / Dysfunctional immune response in COVID-19 patients. What does the evidence tell us?

In December 2019 a novel coronavirus (SARS-CoV-2) was identified in Wuhan, China, and became rapidly the worst pandemic in 100 years. Coronaviruses are respiratory viruses that can cause diseases ranging from mild to fatal lower respiratory tract infections. In a fraction of the affected patients, coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, can lead to acute respiratory distress syndrome (ARDS) and intensive care unit (ICU) admission, both associated with high mortality. To date, the existing evidence suggests a leading role of the immune system in the pathogenesis of severe COVID-19, including mechanisms associated with hyperinflammation, immune evasion, cytokine release syndrome, depletion of functional T cells, and ineffective humoral immunity. Here we discuss the current evidence regarding these findings.

A Evasão nos Cursos de Psicologia no Brasil: Uma Revisão da Literatura / Dropouts in Brazilian Psychology Courses: A Literature Review / La Evasión en los Cursos de Psicología en Brasil: Una Revisión de la Literatura

A evasão no ensino superior apresenta índices significativos de ocorrência nos últimos anos. Buscar conhecer os motivos pelos quais o fenômeno ocorre pode auxiliar a compreendê-lo e pensar estratégias para a sua minimização, principalmente quando estudado o microcontexto (instituição de ensino ou curso superior específico). Este estudo realizou uma revisão da literatura sobre estudos acerca da evasão nos cursos de graduação em psicologia no Brasil, consultando-se para tanto as bases de dados SciELO, Scopus, Banco de Teses e Dissertações da Capes e Biblioteca Digital Brasileira de Teses e Dissertações, sem delimitação de período de busca. Como resultado, percebese inicialmente uma escassez de publicações, com apenas sete estudos encontrados. Quanto aos motivos da evasão, há questões que são gerais dentre as pesquisas que investigam este fenômeno em diferentes cursos superiores, como as dificuldades em conciliar trabalho e estudo, por exemplo, mas também há razões próprias do ambiente de formação em psicologia, como aspectos idealizados sobre a profissão de psicólogo, a busca do curso com finalidade terapêutica, e conflitos entre visões diferentes da psicologia ­ que causavam divergências. Espera-se que os dados e as considerações apresentadas auxiliem os pesquisadores e práticos que se dedicam às questões do ensino superior e, também, àqueles que se dedicam à formação de estudantes nos cursos de graduação em psicologia, uma vez que por meio do conhecimento dos principais motivos elencados por evadidos deste curso como influenciadores do abandono, pode-se planejar e implantar estratégias de prevenção ao fenômeno da evasão....(AU)

Dropout in higher education has presented significant competition rates in the last few years. Seeking to know the reasons why the phenomenon happens can help to understand and create strategies for its minimization, especially when studying its micro-context (specific higher education or course institutions). This study is a literature review about the dropout in Psychology courses in Brazil, referring to the databases SciELO, Scopus, CAPES Thesis and Dissertations Database, and Brazilian Thesis and Dissertations Digital Library, without any search period limitation. As a result, initially a lack of publications was observed, as only seven studies were found. As to the reasons for the dropout, there are general questions among the studies that investigate this phenomenon in different courses, such as the challenges of reconciling work and study, for example, but also reasons specific to the training context in Psychology, such as idealized aspects about the profession of psychologist, the pursuit of the course for therapeutic purposes, and conflicts between different views of Psychology, leading to disagreements. We hope that the data and considerations presented here will help researchers and practitioners who dedicate themselves to higher education issues, as well as those who dedicate themselves to the training of students in Psychology, since, through the knowledge of the main reasons listed for course dropouts, it is possible to plan and implement strategies of prevention to the phenomenon of dropout....(AU)

La evasión en la enseñanza superior tiene índices significativos de ocurrencia en los últimos años. Buscar conocer los motivos por los cuales ocurre el fenómeno puede auxiliar en su comprensión y pensar estrategias para su minimización, principalmente cuando se estudia el microcontexto (institución de enseñanza o curso específico). Este estudio realizó una revisión de la literatura sobre la evasión en los cursos de graduación en Psicología en Brasil, utilizando las bases de datos SciELO, Scopus, Banco de Tesis y Disertaciones de CAPES y Biblioteca Digital Brasileña de Tesis y Disertaciones, sin delimitación de período de búsqueda. Los resultados apuntan inicialmente una escasez de publicaciones, con tan solo siete estudios encontrados. En cuanto a los motivos de la evasión, hay cuestiones que son generales entre las investigaciones que estudian este fenómeno en diferentes cursos de enseñanza superior, como las dificultades de conciliar trabajo y estudio, por ejemplo, pero también hay razones propias del ambiente de formación en Psicología, como aspectos idealizados sobre la profesión de psicólogo, la búsqueda del curso con finalidad terapéutica, y conflictos entre visiones diferentes de la Psicología, que causaban divergencias. Se espera que los datos y las consideraciones presentadas ayuden a los investigadores y prácticos que se dedican a las cuestiones de la enseñanza superior y también a aquellos que se dedican a la formación de estudiantes en los cursos de graduación en psicología, ya que por medio del conocimiento de las principales razones señaladas por evadidos de este curso como influyentes del abandono, se pueden planificar e implantar estrategias de prevención al fenómeno de la evasión....(AU)

Acompanhamento psicológico e permanência em estudantes universitários / Acompañamiento psicológico y permanencia en estudiantes universitarios / Psychological accompaniment and permanence in university students

El estudio tiene como objetivo establecer la relación entre el acompañamiento psicológico y la permanencia estudiantil, mediante el análisis de las variables individuales, académicas y sociodemográficas. El estudio siguió un diseño Ex post-facto, de tipo descriptivo correlacional con un muestreo censal de 520 estudiantes quienes han asistido a acompañamiento psicológico de manera voluntaria. La información fue obtenida mediante un cuestionario que explora características sociodemográficas, académicas y específicas de seguimiento psicológico. Se realizaron análisis comparativos y correlaciónales encontrando una relación positiva entre la permanencia y el acompañamiento psicológico breve ante crisis situacionales. Adicionalmente, se concluyó que la permanencia estudiantil se relaciona con la edad, el género, el semestre, el promedio, el motivo de consulta y el método terapéutico desarrollado en el proceso de acompañamiento psicológico. Se discutieron los resultados a la luz de antecedentes que han explicado los fenómenos de la permanencia y la deserción en contexto escolares.

O estudo tem como objetivo estabelecer a relação entre o acompanhamento psicológico e a permanência estudantil, mediante a análise das variáveis individuais, acadêmicas e sóciodemográficas. O estudo seguiu um modelo Ex post-facto, de tipo descritivo com uma amostra de censo de 520 estudantes os quais se submeteram a acompanhamento psicológico de maneira voluntária. A informação foi obtida mediante um questionário que explora características sóciodemográficas, acadêmicas e específicas de seguimento psicológico. Realizaram-se análises comparativas e correlacionais encontrando uma relação positiva entre a permanência e o acompanhamento psicológico breve ante crises situacionais. Adicionalmente, concluiu-se que a permanência estudantil se relaciona com a idade, o gênero, o semestre, a média, o motivo de consulta e o método terapêutico desenvolvido no processo de acompanhamento psicológico. Discutiram-se os resultados à luz de antecedentes que explicam os fenômenos da permanência e a deserção em contextos escolares.

The study aims to establish the relationship between psychological support and university permanence, through the analysis of individual, academic and sociodemographic variables. The study followed an ex post-facto, descriptive correlational design with a census sampling of 520 students who have voluntarily attended psychological support. The information was obtained through a questionnaire that explores sociodemographic, academic and specific characteristics of psychological follow-up. Comparative and correlational analyzes were performed finding a positive relationship between permanence and brief psychological accompaniment in the face of situational crises. Additionally, it was concluded that university permanence is related to age, gender, semester, average, the reason for consultation and the therapeutic method developed in the psychological accompaniment process. The results were discussed in the light of background that have explained the phenomena of permanence and dropout in school context.

Expression of PD-L1 in triple negative breast cancer tissues and its relationship with angiogenesis / 中国肿瘤生物治疗杂志

@# Objective: To investigate the expressions of programmed death ligand 1（PD-L1）in triple-negative breast cancer (TNBC) and its correlation with angiogenesis. Methods: 120 cases of TNBC patients who underwent surgery in the Fourth Hospital of Hebei Medical University from March 1, 2011 to June 1, 2012 were collected. The tumor tissues of patients were surgically resected and confirmed by pathology. PD-L1 protein expression in TNBC tissues of 120 patients was detected by tissue microarray combined with immunohistochemistry, and its relationship with various clinical indicators was analyzed. Blood vessels and lymphatic vessels were labeled withCD34andD2-40todetectmicrovesseldensity(MVD)andlymphaticvesseldensity(LVD)inTNBC.Results:Thepositiveexpression rate of PD-L1 in the tumor cells and interstitial infiltrating lymphocytes fromTNBC was 56.7% (68/120); No correlation was found between PD-L1 protein expression and the gender, age, histological grade, clinical stage, or tumor size of patients with TNBC (P>0.05), but related to the lymph node metastasis (P<0.05) and vascular thrombus (P<0.05). TNBC with high PD-L1 expression exhibited high incidence of lymph node metastasis and formation of vascular thrombus, and the expression of PD-L1 was positively correlated with MVD (r=0.500, P=0.02) as well as LVD (r=0.662, P=0.01). Log-Rank test showed that the survival time of TNBC patients with positive PD-L1 protein expression was significantly shorter than that of patients with negative expression (P<0.05). Cox multivariate analysis suggested that PD-L1 protein expression could be an independent prognostic factor for TNBC overall survival. Conclusion: PD-L1 plays an important role in TNBC angiogenesis and lymphangiogenesis, and is closely related to TNBC invasion and metastasis; blocking PD1/PD-L1 signal pathway is expected to be an effective new strategy for TNBC treatment.

Klotho protein inhibits Treg/TH17 cell-mediated immune escape of cervical cancer cells by regulating TGF-β1/Foxp3/RORγt signaling pathway / 中国肿瘤生物治疗杂志

@#Objective: To study the effect of anti-aging Klotho protein on immune escape mediated by regulatory T cells (Treg)/helper T cells 17 (TH17) in mice bearing cervical cancer and its mechanism. Methods: The model of cervical cancer-bearing mice were established, and the control group (normal mice), model group (cervical cancer-bearing mice model), and Klotho treatment group (cervical cancer-bearing mice treated with Klotho protein, 200 ng/d) were set up. The weight of cervical cancer tumors in mice of each group was weighed at 7 and 14 days after treatment respectively, PBMCs were separated at the same time. Flow cytometry was used to detect the changes of T lymphocyte function and the proportion of Treg and TH17 cells in mice. qPCR was used to detect the expressions of Foxp3 and RORγt, the key transcription factors of Treg/TH17 cells, in PBMCs of mice in each group. The changes of IL-17, IL-6, IL10, TGF-β and IL-23 in PBMCs were detected by ELISA. The protein expressions of Klotho, TGF-β, Foxp3 and RORγt in PBMCs of mice were detected by WB assay. Results: On the 14th day, the tumor inhibition rate of the cervical cancer-bearing mice in the Klotho group was significantly higher than that in the Model group [(52.16±8.25)% vs (23.33±6.29)% the model group to be supplemented, P< 0.05). Compared with the Control group, the ratios of Treg and TH17 cells in the lymphocytes of the tumor-bearing mice significantly increased (all P<0.05), the ratios of total T lymphocytes (CD3+), auxiliary/induced T lymphocytes (CD3+CD4+) and immune index (CD3+CD4+/CD3+CD8+ cells) decreased significantly (all P<0.05); in addition, the mRNAexpressions of Foxp3 and RORγt genes, cytokines of IL-17, IL-6, IL-10, TGF-β and IL-23, as well as protein expressions of TGF-β1, Foxp3 and RORγt increased significantly (all P <0.05), while the level of Klotho protein significantly decreased in Model group (P<0.05). Compared with the Model group, the above indicators showed opposite changes in Klotho group (P<0.05), but there was no significant difference with the Control group (all P> 0.05). Conclusion: Klotho protein may inhibit Treg/TH17 cell-mediated immune evasion in cervical cancer-bearing mice by inhibiting TGF-β1/Foxp3/RORγt signaling pathway and exert anti-tumor effect.