Dializabilidad de hierro y zinc en cereales para desayunos comerciales fortificados con hierro elemental, sulfato ferroso o edta férrico sódico / Iron and zinc dialysability in commercial breakfast cereals fortified with elemental iron, ferrous sulphate or ferric sodium edta

Iron (Fe) and Zinc (Zn) dialyzability was compared in 7 commercial ready-to-eat breakfast cereals (BC). Four of them were fortified with elemental Fe and ZnO. Fe and Zn dialyzability of 3 different types of BC fortified with ZnO and FeNa2EDTA or FeSO4 was also performed in our laboratory. An in vitro methodology that measures the percentage of mineral dialyzability (D percent) with controlled pH was used. The DFe percent values obtained for the commercially fortified BC ranged between 0.4 to 15.0 percent without milk and between 1.0 to 5.6 percent when milk was added to the cereals. In the case of Zn, the values ranged from 3.3 to 16.1 without milk and between 3.3 and 30.8 when milk was added. Almost every BC that was experimentally fortified in our laboratory presented a higher DFe percent (19.5 to 28.6 percent) and DZn percent (12.4 to 29.2) when fortified with FeNa2EDTA (with or without milk). The results obtained suggest that FeNa2EDTA is a viable alternative for the fortification of BC.

Se comparó la dializabilidad de Fe y Zn en 7 cereales para desayuno comercialmente fortificados o no, con Fe elemental y ZnO y se comparó la dializabilidad de Fe y Zn en tres tipos diferentes de cereales experimentalmente fortificados con ZnO y FeNa2EDTA o FeSO4 en el laboratorio. Se utilizó una metodología in vitro que mide el porcentaje de dializabilidad (D por ciento) del mineral en condiciones controladas de pH. Los cereales comercialmente fortificados presentaron valores de DFe por ciento entre 0,4 y 15,0 y entre 1,0 y 5,6; sin y con leche. Para DZn por ciento los valores fueron entre 3,3 y 16,1 y entre 3,3 y 30,8, sin y con leche. Casi todos los cereales fortificados en el laboratorio presentaron mayor DFe por ciento (entre 19,5 y 28,6) y DZn por ciento (entre 12,4 y 29,2) cuando fueron fortificados con FeNa2EDTA (con y sin leche). Los resultados obtenidos muestran al FeNa2EDTA como una alternativa viable para la fortificación de cereales para desayuno.

The Effect of Ferrous Glycine Sulfate in Rat Iron-deficiency Anemia Model / 浙江中医药大学学报

[Objective] To synthesize an amino acid coordinately compounds-Ferrous Glycine Sulfate(FeGly2) using Fe2+ as central iron and study the effect of blood enrichment.[Method]To synthesize the chelate iron using glycin and Fe2+ and measure the constructor of Ferrous Glycine Sulfate by IR spectrum and atomic absorption spectroscopy.To observe the blood enrichment effect of FeGly2 by rat anemia model.[Result] After separately treatment with 200 mg/kg FeGly2 and 300 mg/kg FeSO4 by intragastric administration,the haemoglobin in blood of hypoferric anemia rat increased obviously(P

Effect of Antioxidants on FeSO4 Toxicity in Cultured Myocardial Cells / 체질인류학회지

In order to elucidate the cardiotoxicity of FeSO4 in cultured myocardial cells derived from neonatal rat, cardiotoxicity was measured by MTT assay when cultured cells were treated with various concentrations of FeSO4. In addition, the cardioprotective effect of antioxidants, glutathione and ascorbic acid was evaluated by MTT assay in these cultrures. Cell viability was remakably decreased in a dose -dependent manner after exposure of cultured rat myocardial cells to 20 microM FeSO4 for 48 hours. In the cardioprotective effect of antioxidants on FeSO4 -induced toxicity, glutathione blocked the cardiotoxicity induced by FeSO4, while ascorbic acid was not effective in blocking FeSO4 -induced cardiotoxicity in these cultures. These results suggest that FeSO4 is toxic in cultured myocardial cells from neonatal rat and selective antioxidants such as glutathione are effective in blocking the cardiotoxicity induced by FeSO4.

NEGATIVE INOTROPISM OF THE EFFECT OF FeSO_4 ON ISOLATED GUINEA PIG HEART ATRIUM / 西安交通大学学报(医学版)

The effects of FeSO_4 upon the physiologicproperties were studied with isolated guinea pig a-trium. The FeSO_4 0. 2mmol/L, makes the contrac-tility of the atrium muscle decrease from 100% ofcontrol to 67 ? 9%. The concentration ofepinephrine inducing automaticity increased andthe duration-intensity curve was shifted to theright. The functional refractory period (FRP) wasprolonged from 298 ? 26 ms to 402 ? 43 ms. Thenegative inotropism and the inhibition of the auto-maticity suggest that FeSO_4 may influence Ca~(2+)movement, while the excitability of suppressionand prolongation of FRP indicate that it may bedue to its inhibition of Na~+ influx.