RESUMEN
OBJECTIVE: To optimize the formulation and preparation process of fast-dissolving PVP microneedles, and provide a high-quality carrier for PVP drug-loaded microneedle research. METHODS: On the basis of single factor, the needle tips dissolution time and insertion ratio were used as the evaluation indexes, and the optimal preparation process of microneedle was optimized by Box-Behnken method. RESULTS: From the single factor test and the Box-Behnken test, it was known that the optimum preparation conditions were as follows: the needle tip concentration was 0.70 g•mL-1, the temperature was 40 ℃, and the humidity was 40%. The microneedle height was 600 μm, the width was 200 μm, the pitch was 500 μm, quadrangular pyramid. The area of the microneedle patch was 0.56 cm2, the dissolution time in water was (41.00±3.74)s, and the insertion ratio was (93.19±5.25)%. CONCLUSION: The PVP fast-dissolving microneedles can be prepared simply and conveniently by the Box-Behnken method, which provides a reference for the preparation of further drug-loaded microneedles.
RESUMEN
Recently, dry powder inhalation (DPI) has become a hotspot in the research area of pulmonary drug delivery (PDD). With the development of drug micronization technology and the emergence of innovative inhaler device, DPI has now been widely applied. This article introduces the formulation composition of DPI, which consists of micronized drug particles, carrier and inhaler device, and the formulation factors of influencing the aerosolizing and deposition properties are emphatically reviewed.