RESUMEN
Pyroptosis is a novel process of programmed inflammatory necrosis, which is closely related to microbial infections and autoimmune diseases. In recent years it has been proved that Gasdermin D is an executive protein of pyroptosis. Cleaved Gasdermin D leads to the formation of pores in cell membrane to induce pyroptosis, and the release of inflammatory factors such as IL-1β and IL-18 aggravates the occurrence of inflammatory responses. With the deepening of Gasdermin D research, it is gradually clear its protein structure and activation sites, which has other activation pathways apart from inducing inflammasome activation. Activation of Gasdermin D does not necessarily mean cell death, even if it could induce the formation of pores in cell membrane and regulation of inflammatory cytokine secretion. These findings offer insight into Gasdermin D function and change our understanding of pyroptosis and programmed necrosis. The recent progress of Gasdermin D is highlighted in this review.
RESUMEN
Pyroptosis is a fairly new type of cell death that is frequently mediated by inflammasomes and is strongly related to Gasdermin protein family and cysteinyl aspartate specific proteinase (caspase). The importance of pyroptosis-related molecules in the occurrence and progression of gynecological diseases cannot be overstated. This article reviews the related mechanism of cell pyroptosis, and the relationship between pyroptosis and benign and malignant gynecological diseases, so as to provide references for the research of the diagnosis and treatment of gynecological diseases, as well as the development of targeted drugs.
RESUMEN
Pyroptosis is an inflammatory programmed cell death. Unlike apoptosis, pyroptosis is always accompanied by inflammation. It has been found that cell pyroptosis is closely related to the occurrence and development of many diseases. Pyroptosis also plays an important role in radiation injury caused by radiotherapy. Ionizing radiation breaks DNA in cells and induces oxygen free radicals, which are good inducers of pyroptosis. Therefore, this paper reviewed the research progress on the mechanism of cell pyroptosis in radiation injury from the perspective of relative signaling pathways, in order to provide new ideas for weakening or blocking radiation injury.
RESUMEN
Gasdermin family (GSDMs), consisting of six proteins (GSDMA, GSDMB, GSDMC, GSDMD, GSDME and DFNB59) in humans and ten proteins (GSDMA1-3, GSDMC1-4, GSDMD, GSDME and DFNB59) in mice, might be involved in multiple physiological and pathological processes, including epithelial cell development, apoptosis, inflammation, carcinogenesis and immune-related diseases. Recent studies confirmed GSDMD, which containing an N-terminal domain with pore-forming activity and a C-terminal domain with structural autoinhibition, as a crucial substrate of inflammatory caspases in pyroptosis, pioneering a new area for structural and functional research on Gasdermin family proteins. This review will summarize the latest progress in the structures, functions and association with diseases of several Gasdermin family proteins.
RESUMEN
Gasdermin family (GSDMs), consisting of six proteins (GSDMA, GSDMB, GSDMC, GSDMD, GSDME and DFNB59) in humans and ten proteins (GSDMA1-3, GSDMC1-4, GSDMD, GSDME and DFNB59) in mice, might be involved in multiple physiological and pathological processes, including ep-ithelial cell development, apoptosis, inflammation, carcinogenesis and immune-related diseases. Recent studies confirmed GSDMD, which containing an N-terminal domain with pore-forming activity and a C-termi-nal domain with structural autoinhibition, as a crucial substrate of inflammatory caspases in pyroptosis, pio-neering a new area for structural and functional research on Gasdermin family proteins. This review will sum-marize the latest progress in the structures, functions and association with diseases of several Gasdermin fam-ily proteins.