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1.
Rev. méd. Chile ; 147(1): 119-124, 2019. graf
Artículo en Español | LILACS | ID: biblio-991382

RESUMEN

IgG4 related disease is a systemic autoimmune disease, which can affect different organs. The most common digestive manifestation is autoimmune pancreatitis (AIP), followed by involvement of bile ducts and the major papilla. The stomach is only rarely involved. We report a 71-year-old diabetic woman consulting for jaundice and weight loss. Abdominal CAT scan, cholangio resonance imaging, endosonography and a serum IgG4 of five times the normal value, lead to the diagnosis of an autoimmune pancreatitis. An upper gastrointestinal endoscopy showed a diffuse thickening of gastric folds. The pathological study confirmed the presence of IgG4 positive plasma cells. The patient was successfully treated with steroids.


Asunto(s)
Humanos , Femenino , Anciano , Enfermedad Relacionada con Inmunoglobulina G4/patología , Gastritis Hipertrófica/patología , Pancreatitis/patología , Biopsia , Inmunohistoquímica , Tomografía Computarizada por Rayos X/métodos , Gastroscopía/métodos , Enfermedad Relacionada con Inmunoglobulina G4/diagnóstico por imagen , Mucosa Gástrica/patología , Gastritis Hipertrófica/diagnóstico por imagen
2.
Chinese Journal of General Surgery ; (12): 601-604, 2019.
Artículo en Chino | WPRIM | ID: wpr-755869

RESUMEN

Objective To investigate the clinical features of Menetrier disease and the related treatment progresses.Methods The clinical data of 7 patients with Menetrier disease who were admitted to Cangzhou Central Hospital from Jan 1997 to Mar 2018 were retrospectively analyzed.Results There were 3 males and 4 females.The main clinical manifestations were abdominal pain (n =5),loss of appetite (n =4),nausea and vomiting (n =2),weight loss (n =4),edema (n =3),hypoalbuminemia (n =6) and anemia (n =6).All patients had typical imaging findings.Two of the patients underwent non-surgical treatmen with temporary symptom reliefs.Finally,6 patients received surgical treatment including Subtotal gastrectomy in 1 patient,total gastrectomy in 5 patients.All the 6 cases underwent surgery successfully with no serious complications.5 cases were followed-up data until April 2018.All were in good condition,Hemoglobin and albumin levels were within the normal range.Conclusion According to the clinical manifestations and the related auxiliary examinations,this disease is easy to diagnose.Surgical treatment is the only way to cure Menetrier disease.

3.
Clinical Endoscopy ; : 89-94, 2018.
Artículo en Inglés | WPRIM | ID: wpr-739687

RESUMEN

Ménétrier’s disease (MD), which is characterized by hypertrophic gastric folds and foveolar cell hyperplasia, is the most common gastrointestinal (GI) cause of protein-losing enteropathy (PLE). The clinical course of MD in childhood differs from that in adults and has often been reported to be associated with cytomegalovirus (CMV) infection. We present a case of a previously healthy 22-month-old boy presenting with PLE, who was initially suspected to have an eosinophilic GI disorder. However, he was eventually confirmed, by detection of CMV DNA using polymerase chain reaction (PCR) with gastric tissue, to have MD associated with an active CMV infection. We suggest that endoscopic and pathological evaluation is necessary for the differential diagnosis of MD. In addition, CMV DNA detection using PCR analysis of biopsy tissue is recommended to confirm the etiologic agent of MD regardless of the patient’s age or immune status.


Asunto(s)
Adulto , Niño , Humanos , Lactante , Masculino , Biopsia , Infecciones por Citomegalovirus , Citomegalovirus , Diagnóstico Diferencial , ADN , Eosinófilos , Gastritis Hipertrófica , Hiperplasia , Reacción en Cadena de la Polimerasa , Enteropatías Perdedoras de Proteínas
4.
Korean Journal of Pediatrics ; : 293-296, 2012.
Artículo en Inglés | WPRIM | ID: wpr-32998

RESUMEN

Menetrier's disease is a rare form of acquired gastropathy characterized by giant rugal folds in the stomach and protein-losing gastropathy. Children with Menetrier's disease tend to follow a benign self-limited course with symptoms typically completely resolving within 2 to 10 weeks in contrast to the chronic course in adults. A 9-year-old girl presented with a history of gradually worsening abdominal distension, increasing body weight, and abdominal pain for 2 weeks. Physical examination on admission indicated periorbital swelling, pitting edema in both the legs, and abdominal distension with mild diffuse tenderness and shifting dullness. Laboratory tests on admission showed hypoalbuminemia, hypoproteinemia, and peripheral eosinophilia. The test result for anticytomegalovirus immunoglobulin M was negative. Increased fecal alpha 1 anti-trypsin excretion was observed. Radiological findings showed massive ascites and pleural effusion in both the lungs. On gastroscopy, large gastric folds, erythema, erosion, and exudation were noted in the body and fundus of the stomach. Microscopic findings showed infiltration of eosinophils and neutrophils in the gastric mucosa. Her symptoms improved with conservative treatment from day 7 of hospitalization and resolved completely.


Asunto(s)
Adulto , Niño , Humanos , Dolor Abdominal , Ascitis , Peso Corporal , Citomegalovirus , Edema , Eosinofilia , Eosinófilos , Eritema , Mucosa Gástrica , Gastritis Hipertrófica , Gastroscopía , Hospitalización , Hipoalbuminemia , Hipoproteinemia , Inmunoglobulina M , Pierna , Pulmón , Neutrófilos , Examen Físico , Derrame Pleural , Enteropatías Perdedoras de Proteínas , Estómago
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