RESUMEN
OBJECTIVE:To study the compatibility of gatifloxacin for injection with famotidine for injection in 0.9% sodium chloride injection or 5% glucose injection.METHODS:At room temperature ((20?1)℃)for 8 hours,the changes of the mixture in appearance,pH and UV spectra were observed,and the contents of gatifloxacin and famotidine were determined by ultraviolet spectrophotometry.RESULTS:No significant change was found in pH values and contents within 8h after mixing of the two drugs,nor significant changes were found for the mixture in appearance within 8h in 0.9% sodium chloride injection or within 6h in 5% glucose injection.CONCLUSION: The mixture of gatifloxacin for injection and famotidine for injection were stable in 0.9% sodium chloride injection or 5% glucose injection.
RESUMEN
OBJECTIVE:To study the compatible stability of gatifloxacin for injection and cimetidine injection in 0.9% sodium chloride injection or in 5% glucose injection.METHODS:Changes in appearance and pH value of gatifloxacin in combination with cimetidine within 8 hours after mixing were respectively observed and determined under room temperature(20?1)℃,and the content was determined by UV spectrophotometry.RESULTS:No significant change was seen in appearance and pH value after two hours of mixing of the two agents.But after four hours of mixing,the content of cimetidine went up in both solvents,and its pH value rose slightly in 0.9% sodium chloride injection.CONCLUSION:Gatifloxacin for injection can be mixed with cimetidine injection in 0.9% sodium chloride injection or 5%glucose for injection to use,but the compatible liquid should be used up in 2 hours.
RESUMEN
OBJECTIVE:To study the compatible stability of gatifloxacin for injection with tinidazole injection.METHO_DS:Contents changes of gatifloxacin and tinidazole within 48h after mixing were determined by HPLC;and the appearance,pH value were observed and determined.RESULTS:The contents changes for both gatifloxacin and tinidazole were less than 5%. The mixed solution was clear in appearance yet without generation of gas and sediments.No significant changes were noted in pH value,color and smell.CONCLUSION:The mixed solution of gatifloxacin for injection with tinidazole injection is stable at room temperature within 48h and which can be applied in combination.
RESUMEN
OBJECTIVE:To study the compatibility of gatifloxacin for injection with etamsylate injection in 0.9% sodium chloride injection and 5% glucose injection.METHODS:The appearance of the mixture of gatifloxacin for injection with etams-ylate injection in 0.9% sodium chloride injection and 5% glucose injection at room temperature,i.e.(20?1)℃ within 8 hours was observed,with its pH measured and ultraviolet spectra observed.The contents of gatifloxacin and etamsylate were determined by a dual ultraviolet spectrophotometry.RESULTS:No significant change was noted for the mixture within 8 h in pH and appearance,and the contents of gatifloxacin and etamsylate within 8 h in 0.9% sodium chloride injection or within 6 h in 5% glucose injection showed no obvious change.CONCLUSION:Gatifloxacin for injection can be mixed with etamsylate injection in 0.9% sodium chloride injection or 5% glucose injection.