Treatment of a Giant Pigmented Nevus using an Alloderm: A Case Report

Because a giant pigmented nevus has the risk of malignant transformation to malignant malanoma, early surgical excision is recommended. There have been various types of surgical methods in a giant pigmented nevus, for example dermabrasion, staged excision, skin graft, local flap and tissue expander. The authors have used an alloderm combined with a very thin split thickness skin graft in the treatment of a giant pigmented nevus. Among the 3 patients we operated in 1999, we could not find a significant cosmetic difference compaired with the conventional split thickness skin graft. Our method with the use of an alloderm combined with a very thin split thickness skin graft would be considerable in the treatment of a giant pigmented nevus, because it shows less visible scars in donor site than conventional split thickness skin graft. Moreover, we could harvest skin graft from the same site twice or more times.

Congenital malignant melanoma: a case report

Herein reported is a case of congenital malignant melanoma in a premature male baby from a 25-year-old healthy mother who was found to have hydramnios at the 29th week of gestation. The pregnancy was interrupted because of a large posterior neck mass detected by ultrasonography. The large neck mass of the baby was a malignant melanoma involving deep dermis and subcutaneous tissue. The skin over the mass showed a large area of pigmentation with hairs and the pigmentation involved the occipital scalp and posterior neck. Microscopically, the tumor cells were monotonous and showed polygonal and epithelioid appearance with prominent nucleoli indicative of malignant melanoma of a minimal deviation variety. Neither junctional components nor benign dermal nevus cells were noted. There were no distant metastasis or underlying leptomeningeal melanosis. This tumor is presumed to have developed from either preexisted congenital giant pigmented nevus with loss of benign components or de novo origin.

A Case Report of Giant Pigmented Nevus Associated with Porencephaly: A Variant of Neurocutaneous Melanosis

Giant pigmented nevus is a variety of congenital melanocytic nevi, and may be associated with various abnormalities, such as skeletal malformation, lipoma, vascular nevi, melanosis in the meninges, meningocele, and intracranial arteriovenous malformation. We report a case with congenital giant pigmented nevus and porencephaly. This association should be considered as the spectrum of neurocutaneous syndromes related to congenital giant pigmented nevus.

Congenital Giant Pigmented Nevus with Malignant Melanoma of Brain / 대한피부과학회지

We report a case of congenital giant pigmented nevus with malignant melanoma of brain in a 14-year-old male patient. He had giant pigmented nevus on the back and neck, and multiple satellite lesions over the whole body since birth. One year prior to visit to our hospital, the patient suffered from various neurologie symptoms including headache, nausea, vomiting, seizure and right side motor weakness. Flistologic findings of skin lesions were benign nevocytic nevi. Computed tomogram of brain demonstrated increased densities in the both fronto-parietal leptameninges and brain parenchyme. Histologic findings of brain parenchyme by stereotaxic long needle biopsy showed the infiltration of melanin containing atypical melanocytes. There was no evidence of malignant melanoma at other organs. All of these findings suggested that origin of malignant melanoma of brain parenchyme was leptomeninges rather than skin.