RESUMEN
Objective To approach the effects of Gingkgo biloba extra(GBE)on expression of P-selectin and myeloperoxidase(MPO)activity of cerebral ischemia-reperfusion injury in rats.Methods The rats were randomly divided into sham operated group,ischemia-reperfusion group,low dose GBE group and high dose GBE group.The models of ischemia-reperfusion were established by focal middle cerebral artery occlusion(MCAO)method.Rats were given high or low dose GBE intraperitoneally,30 min before MCAO.The expression of P-selectin was tested by immunohistochemistry and the MPO activity by chromatometry in the rat brain.The volume of cerebral infarction and the pathologic changes were observed by HE staining and TTC staining.Results(1)Compared with sham operated group,the expression of P-selectin and MPO activity were increased in models of ischemia-reperfusion(allP
RESUMEN
Objective To study the effects of basic fibroblast growth factor (bFGF) and Gingkgo biloba extra(GbE) on experimental cerebral infarction. Methods 40 healthy adult cats were equally devided into group A with sodiumchloride, group B with bFGF, group C with GbE and group D with bFGF+GbE in random.All animals were operated to establish the feline models of cerebral focal ischemia-reperfusion by the approach of left transorbital. The certain madicine intervene were take at 0 h,24 h,48 h after the models established.The neurological defects score was evaluated by Philips' criteria score in 1 d and 7 d. The physiological changes were observed by HE stained and electron microscope.Results The neurological defects score was singificiant lower in D group(41.50?8.18) than that in group A(82.20?8.08),B(63.60?6.22) and C (61.00?6.58)(allP