Malignant Glomus Tumor of the Peritoneum: Case Report

Glomus tumors are usually benign tumors that occur in the skin and soft tissues of the extremities. Visceral locations, such as stomach, intestines or lung, are extremely rare because glomus bodies are rare or absent in these organs. This report describes our experience in a 47-year-old woman diagnosed with a peritoneal malignant glomus tumor. This finding has not been previously reported.

Glomus tumour of the hands: A review of presentations and outcomes

Introduction: Glomus tumour is a rare benign neoplasm of the normal neuroarterial structure called glomus body. They present with obscure symptoms making diagnosis difficult and delayed. Though classical symptoms and signs such as pain, temperature sensitivity, and point tenderness are described, imaging such as magnetic resonance imaging is increasingly being used for diagnosis. The aim of this study was to review the current understanding of glomus tumours of the hand in the context of the cases treated in Brunei Darussalam emphasising the importance of detailed clinical examination over imaging modalities. Materials and Methods: We present a series of seven patients diagnosed as glomus tumour and operated in our hospital from Sept 1997 to Sept 2009. Data was collected from the clinical and operative records regarding preoperative history and workup, intraoperative details, postoperative follow up and histopathology. Results: There were three male and four female patients with a median age of 37 years. All patients had severe fingertip pain on touch with positive Love's test. One patient had hypersensitivity to cold. Presumptive diagnosis of glomus tumour was made in six patients and foreign body granuloma in one patient based on detailed history and clinical examination alone. Histopathology confirmed glomus tumour in all the patients. All are asymptomatic after surgery. One patient had increased mitotic activity on histopathological examination and is on close follow up. Conclusion: High suspicion, detailed history and careful physical examination can significantly decrease the pre-operative morbidity of the patient with glomus tumour. An imaging study may not always be required for diagnosis.

A Case of Malignant Glomus Tumor / 대한피부과학회지

Malignant glomus tumor, or glomangiosarcoma, is a very rare neoplasm that typically arises from a benign glomus tumor. Despite having the histological features of malignancy, these tumors usually do not metastasize. We report a case of malignant glomus tumor on the finger of an 18-year-old man. By histology, round to ovoid tumor cells showed a uniform appearance of round nuclei. Many mitotic figures and nuclear atypia were observed. Immunohistochemically, vimentin and alpha-smooth muscle actin showed intense staining. This case was considered to be a malignant glomus tumor. Thus, it was a glomangiosarcoma arising de novo.

Malignant Glomus Tumor Arising in Benign Glomus Tumor

The glomus tumor is a distinct neoplasm composed of modified perivascular smooth-muscle cells identical to those described in the glomus body. Malignant glomus tumor, also referred to as glomangiosarcoma, is exceedingly rare. It has been subdivided into locally infiltrative glomus tumor, glomangiosarcoma arising in a benign glomus tumor, and glomangiosarcoma arising in de novo. A few cases of malignant glomus tumor arising in a benign glomus tumor have been reported. A 55-year-old man underwent resection of a solitary nodule in the right shoulder area. The tumor was biphasic with a typical benign glomus tumor at the periphery and the central sarcomatous area composed of oval to elongated pleomorphic cells with a single prominent nucleolus and occasional mitotic figures. Both tumor components showed intense staining for vimentin, smooth muscle actin, and muscle specific actin. Herein, we report a case of a malignant glomus tumor arising in a benign glomus tumor with an immunohistochemical study and a review of literatures.

Subungual Glomangiosarcoma: A Case Report / 대한정형외과학회잡지

Glomangiosarcoma is a histopathologically defined extremely rare malignant tumor that accompanies a glomus tumor usually, but its has benign clinical course characteristically. It shares common ultrastructural and immunohistochemical features with glomus tumor, and transformed possibly from glomus tumor". Glomangiosarcoma shows more sarcomatous appearance histologically than glomus tumor, however with no malignant behavior(i.e. recurrence or metastasis) was expressed. We experienced a case of glomangiosarcoma form subungual region treated by marginal excision and no recurrence or metastasis was developed untill 1 year and 6 months postoperatively.

Malignant glomus tumor originating in the superior mediastinum: an immunohistochemical and ultrastructural study

An extremely rare case of malignant glomus tumor originating in the superior mediastinum was evaluated immunohistochemically and ultrastructurally. A 78-year-old woman who had been suffering from dysphagia and dyspnea had poorly-defined soft tissue mass, 4.5 x 2.5cm, in the superior mediastinum with direct invasion into the esophagus, trachea, and bilateral thyroid glands. This case is believed to be unique in several respects. There were neither recognizable findings of benign glomus tumor nor sarcomatous areas, in contrast to the previously reported cases. A definite direct invasion into the surrounding organs was identified. We therefore interpreted this case as primary malignant glomus tumor, not as glomangiosarcoma arising in a benign glomus tumor.